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Phage Display Antibody Engineering Jobs (NOW HIRING)

BigHat

Scientist I, Display Technologies

San Mateo, CA · On-site

$120K - $145K/yr

... antibody formats (VHH, scFv, Fab) using standard molecular biology techniques (PCR, molecular cloning, electroporation). * Execute standard phage display selections to engineer antibodies with ...

Prellis Biologics, Inc.

Partner closely with the Antibody Protein Engineering team on hit‑to‑lead transitions and ... Hands‑on experience developing and deploying display platforms (yeast, phage, mammalian, ribosome ...

Meso Scale Discovery

Scientist

Gaithersburg, MD

$101K - $154K/yr

... o Phage display, antibody discovery (or antibody engineering), and molecular biology OR structural biology and membrane protein experience highly desirable. o Supervisory/management experience ...

MSD

Scientist

Gaithersburg, MD · On-site

$101K - $154K/yr

... o Phage display, antibody discovery (or antibody engineering), and molecular biology OR structural biology and membrane protein experience highly desirable. o Supervisory/management experience ...

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Phage Display Antibody Engineering information

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$40.5K

$98.8K

$156.5K

How much do phage display antibody engineering jobs pay per year?

As of Sep 12, 2026, the average yearly pay for phage display antibody engineering in the United States is $98,759.00, according to ZipRecruiter salary data. Most workers in this role earn between $78,000.00 and $116,000.00 per year, depending on experience, location, and employer.

What is phage display antibody engineering?

Phage display antibody engineering is a laboratory technique used to generate and select antibodies with specific binding properties. In this method, bacteriophages (viruses that infect bacteria) are genetically engineered to display antibody fragments on their surfaces. Scientists can then screen large libraries of these phage-displayed antibodies to identify those that bind to a target antigen with high affinity and specificity. This technique is widely used in drug discovery, diagnostics, and therapeutic antibody development. Phage display allows for rapid and efficient selection of antibodies without the need for animal immunization.

What are the key skills and qualifications needed to thrive as a phage display antibody engineer?

To thrive as a Phage Display Antibody Engineer, you need a strong background in molecular biology, protein engineering, and immunology, usually supported by an advanced degree in a life science field. Proficiency in phage display techniques, molecular cloning, ELISA, and data analysis software such as Prism or FlowJo is typically required. Attention to detail, problem-solving, and strong communication skills are essential soft skills for designing experiments and collaborating within multidisciplinary teams. These competencies ensure the successful development, selection, and optimization of therapeutic antibodies critical for research and biopharmaceutical innovation.

What are some typical challenges faced when working in phage display antibody engineering, and how can they be addressed?

Professionals in Phage Display Antibody Engineering commonly encounter challenges such as optimizing library diversity, minimizing non-specific binding, and ensuring the stability and specificity of selected antibodies. Addressing these issues often involves carefully designing and validating libraries, employing rigorous selection (panning) protocols, and collaborating closely with molecular biologists and protein chemists to troubleshoot experimental results. Regular communication within multidisciplinary teams and staying updated with advancements in selection technologies can also help overcome technical barriers and improve project outcomes.

What is the difference between Phage Display Antibody Engineering vs Monoclonal Antibody Production?

AspectPhage Display Antibody EngineeringMonoclonal Antibody Production
CredentialsBiotech or molecular biology degree, lab experienceSimilar credentials, often with immunology focus
Work EnvironmentResearch labs, biotech companiesResearch and development, manufacturing facilities
Industry UsageAntibody discovery, therapeutic developmentTherapeutic antibody manufacturing, clinical applications

Phage Display Antibody Engineering focuses on selecting and optimizing antibodies using phage display technology, while Monoclonal Antibody Production involves creating specific antibodies for therapies or diagnostics. Both roles require similar educational backgrounds and are integral to biotech and pharmaceutical industries, but they differ in their specific processes and end goals.

Infographic showing various Phage Display Antibody Engineering job openings in the United States as of September 2026, with employment types broken down into 1% Internship, 90% Full Time, 6% Part Time, 2% Contract, and 1% Nights. Highlights an 83% Physical, 4% Hybrid, and 13% Remote job distribution, with an average salary of $98,759 per year, or $47.5 per hour.

Scientist III, Antibody Engineering

San Diego, CA • On-site

Arrowhead Pharmaceuticals
Pharmaceutical and Medicine Manufacturing • 201 - 500 employees
Learn more about Arrowhead Pharmaceuticalsexternal

$120K - $130K/yr

Full-time

Re-posted 25 days ago

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
We are seeking a highly motivated and skilled Molecular Biologist to join our dynamic research team in Discovery Chemistry. The successful candidate will play a key role in antibody engineering to support platform development and drug delivery initiatives. This position requires extensive hands-on experience in phage display, antibody engineering, and antibody characterization, supported by a strong foundation in molecular biology.
Responsibilities
  • Design and construct mutant phage libraries for antibody affinity maturation or humanization.
  • Perform molecular cloning, mutagenesis, antibody gene assembly, and expression vector design.
  • Express and purify recombinant antibodies using bacterial and mammalian expression systems.
  • Perform binding, specific and in vitro functional assays.
  • Collaborate with cross-functional project teams to advance lead antibodies through drug development stages.
  • Maintain accurate documentation and present findings at internal meetings.

Requirements
  • Ph.D. in Biology, Biochemistry, Molecular Biology, or a related field.
  • Hands-on experience with phage display technology for antibody engineering.
  • Proficiency in molecular cloning, PCR, and mutagenesis.
  • Experience with antibody expression and purification using E. coli, HEK293, and CHO systems.
  • Strong analytical and problem-solving skills, with the ability to troubleshoot experiments independently.
  • Excellent record-keeping, communication, and collaboration skills.
  • Proven ability to adapt to fast pace and evolving research priorities
  • Track record of scientific productivity, including peer-reviewed publications, conference presentations, or patents
  • Additional experience in molecular biology and/or antibody discovery is highly desirable

Preferred
  • Industry or postdoc experience

California pay range
$120,000-$130,000 USD
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
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