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Development of genome editing reagents for muscular dystrophy and cancer.

The Wolfe laboratory will be filling a postdoctoral position to develop therapeutic genome editing reagents for muscular dystrophies and cancer. These projects will focus on:

1) The development of prime editing reagents with high activity and specificity for the precise correction of common pathogenic mutations associated with Limb Girdle Muscular Dystrophy.

2) The development of genome editing reagents for selective killing of cancer cells harboring gene amplifications.

3) The utilization of unbiased genome-wide techniques for assessing off-target events and other genomic alterations potentially associated with genome editing.

4) The translation of the developed genome editing reagents to clinical application through in vivo safety and efficacy studies in relevant mouse models.

These studies will expose the successful candidate to cutting-edge genome editor engineering approaches and the delivery of these reagents in vivo via lipid nanoparticles. The successful candidate will also learn cutting edge deep-sequencing approaches to evaluate off-target editing within the genome. They will have the opportunity to participate in meetings/conferences associated with genome editing and gene therapy, which will broaden their exposure to cutting edge research within the field. Candidates should have a Ph.D. in biology, biochemistry, chemistry or a related biomedical science. In addition, the potential candidate must have strong oral and written communication skills and be eager to present research results at national meetings. Prior experience with genome editing systems, cell culture, deep-sequencing technologies and mouse disease models is advantageous but not required.

Applicants should send a letter (via email) describing their current research activities and their interest in this position, a CV (including publications) and contact information for three references, including your Ph.D. advisor.

Address letters to Scot Wolfe (scot.wolfe@umassmed.edu).

University of Massachusetts Chan Medical School

Department of Molecular, Cell and Cancer Biology

364 Plantation Street, LRB Room 619

Worcester, MA 01605

Further details about the Wolfe laboratory can be found at:

https://www.umassmed.edu/Wolfe-Lab/

https://profiles.umassmed.edu/display/133161

UMass Chan Medical School is committed to being an equal opportunity and affirmative action employer and recognizes the power of a diverse community. We encourage applications from protected veterans, individuals with disabilities and those with varied experiences, perspectives and backgrounds to consider UMass Chan Medical School as their employer of choice.