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Job DescriptionSenior Scientist - Process Analytical Technologies (PAT)We are seeking a Senior Scientist to join the Process Analytical Technologies (PAT) team within Analytical Enabling Capabilities at our company. As a member of the PAT team, you will integrate with a motivated and inclusive team of expert scientists passionate about PAT tools application from process development to routine manufacturing. This role offers an exciting opportunity to contribute strong mechanistic organic chemistry expertise to support small molecule active pharmaceutical ingredient (API) process development, with a particular emphasis on reaction mechanism elucidation, reaction monitoring, and impurity understanding.ResponsibilitiesProvide technical leadership for systematic assessment and deployment of in-line, on-line, and at-line PAT methods for API and biologics drug substance development programs.Partner closely with process chemistry teams to define mechanistic questions, design hypothesis-driven studies, and translate mechanistic insights into actionable process development recommendations.Apply PAT to support reaction monitoring, kinetic assessment, intermediate identification, impurity profiling, and structure confirmation during API process development.Design and develop standardized analytical platforms to enable PAT implementation, including real-time monitoring and rapid shop-floor analytics.Develop, validate, and implement PAT methods (in-line, on-line, at-line) to monitor and control process parameters and product quality attributes.Lead scale-up activities and technology transfer of PAT applications to commercial manufacturing.Create integrated control strategies that leverage PAT platforms to enable robust, highly capable manufacturing processes.Prepare and maintain scientific documentation and validation packages for PAT methods; contribute content for regulatory submissions.Interact with global regulatory agencies as needed to support acceptance of PAT-based process control and release strategies.QualificationsRequired B.S./M.S in chemistry, biochemistry, biotechnology, bioengineering, chemical engineering, or a related discipline with a minimum of 3 years of relevant industry experience; or Ph.D. and 0+ years.Strong technical background in elucidation of organic reaction mechanisms as applied to API process development.Strong technical background in optical spectroscopy (Raman, FTIR, NIR), NMR, chromatography, and chemometrics.Preferred Proven track record of scientific contributions (peer-reviewed publications or equivalent technical outputs).Experience supporting pharmaceutical or fine chemical process development, including mechanistic understanding, process optimization, scale-up troubleshooting, control strategy development, and robustness studies.Strong collaborative and interpersonal skills; ability to work across functions and with external partners.EligibleforERPARDRequired Skills: Analytical Method Development, Assay Development, Chromatographic Techniques, GMP Environments, Nuclear Magnetic Resonance (NMR) Analysis, Process Analytical Technology (PAT), Technical Writing, Ultra Performance Liquid Chromatography (UPLC)Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only:Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.--As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.- For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:EEOC Know Your Rights EEOC GINA Supplement• We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.Learn more about your rights, including under California, Colorado and other US State Acts The salary range for this role is $117,000.00 - $184,200.00This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.We offer a comprehensive package of benefits.- Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits .You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully-Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.-Employee Status: RegularRelocation:DomesticVISA Sponsorship:No Travel Requirements: 10%Flexible Work Arrangements:Not ApplicableShift:1st - DayValid Driving License:NoHazardous Material(s):laboratory chemicalsJob Posting End Date:09/14/2026 *A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID:R415024 Salary: . Date posted: 09/01/2026