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Senior Scientist, Discovery Technologies

Cambridge, MA USA

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?

Flagship Labs 129 (FL129) is an early-stage biotechnology startup with an ambitious and exciting mission: to develop a technology to facilitate the data generation necessary for training the next generation of generative chemistry models to unlock the future of small molecule drug discovery. FL129 is developing a revolutionary approach to this challenge and is recruiting a team of top-tier scientists to build this powerful and first-in-category platform. This is a unique opportunity to be one of the first employees of a biotech startup that combines an innovative mindset with the resources and know-how of Flagship Pioneering.

Position Summary:

We are seeking a motivated and highly collaborative Senior Scientist to join FL129’s growing team of experimental and computational scientists to build a novel platform technology. The successful candidate will have strong track record of scientific and technical innovation in molecular biology and small molecule screening, including experience adapting screens to cell- or surface-displayed protein targets. Additional experience with or exposure to yeast surface display, single-cell or genomics methods, and cheminformatics are preferred. The ideal teammate will be highly adaptable, have strong organizational and communication skills, and will thrive in a highly collaborative and multidisciplinary environment.

Key Responsibilities:

• Technology development, aligned with FL129’s core strategic goals. This role is among the first hires, and we’re looking for someone who thinks critically and will influence the company’s scientific direction.


• Design, construction, and experimental testing of custom target/variant libraries, including binding assays against cell- or surface-displayed protein targets


• Optimize existing workflows and establish best experimental and documentation practices to enable platform excellence.


• Ensuring rapid and accurate turnaround of data to drive achievement of key project goals.


• Translate experimental data into meaningful insights and present results at team meetings.

Preferred Qualifications:

• Ph.D. in molecular biology, systems biology, chemical biology, or a similar field with 5+ years of industry or postdoctoral experience.


• End-to-end experience with small molecule screening from library design, including optimization of DNA tags for amplification, quantitation and sequencing, to screening, next-gen sequencing, to data analysis.


• Experience managing contract research organizations (CROs).


• Nice to have: cheminformatics experience, on-DNA and off-DNA hit validation experience with DNA-encoded positive control and library compounds, surface display technologies, droplet-based screening and/or microfluidics, and single-cell or genomics methods.


• Motivated team-player and independent force-of-nature with strong organizational and written/verbal communication skills.

What we can offer you:

• Opportunity to lay the scientific foundation of a transformative platform company as an early employee.


• Custom-tailored role to maximize impactful contributions, professional growth, and scientific interests.


• Weekly lunches, monthly social events, and community lunchroom with free snacks, coffee, all embedded in a vibrant community of scientists and entrepreneurs across multiple Flagship Pioneering portfolio companies.

We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment. The level of the role will be commensurate with the education and years of experience of the identified candidates.

The salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL129 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL129's good faith estimate as of the date of publication and may be modified in the future.

• Healthcare coverage


• Annual incentive program


• Retirement benefits


• Broad range of other benefits

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.