Summary of Position
The Diezmann lab at the University of Minnesota Twin Cities is seeking a Researcher/Lab Manager. As a researcher, the candidate will pursue experiments to understand how DNA repair is coordinated along meiotic chromosomes, including single-molecule microscopy in live nuclei, high-resolution imaging, quantitative data analysis, and the design and maintenance of transgenic C. elegans strains. As a lab manager, the candidate will oversee wet lab operations, microscopy resources, and ordering/budgeting. This position is highly collaborative, with ample opportunities to mentor and learn from lab members, and to publish and present experimental results. The ideal candidate will be excited to help build a lab applying cutting-edge techniques to uncover new mechanisms in cellular biophysics and chromosome biology.
About our Lab
The Diezmann lab works to understand how biological signals emerge from subcellular molecular dynamics. We use high-resolution microscopy and genome engineering to study how competing DNA repair pathways are balanced during meiosis to ensure the faithful transmission of genetic material while creating genetic diversity in each generation. Our lab introduced the use of single-molecule tracking microscopy in live meiotic nuclei in C. elegans, revealing how protein diffusion, binding, and accumulation transduces signals along meiotic chromosomes. Our lab values mutual support, technical mastery, and critical reasoning, and our work supports advances in human reproductive health, crop breeding, and diseases of DNA repair such as cancer.
Essential Functions
70% Research Experimentation
Single-molecule tracking microscopy, high-resolution imaging, image and statistical data analysis in MATLAB and related pipelines. Design genetic constructs, perform genetic and manipulation of C. elegans. Maintain laboratory records, prepare figures, and communicate results.
30% Lab Manager Operations
Administration of ordering and budgeting. Prepare media and other stocks, maintain databases and protocols, safety training and compliance, optimizing lab processes, training new lab members.