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Job #JPF05836

Full Specialist Microbiome of Rheumatic Diseases

The Nayak Lab is seeking a Full Specialist with expertise in microbiome research and immunology, focused on advancing our understanding of the gut microbiome in rheumatic diseases such as rheumatoid arthritis. Our laboratory integrates cutting-edge technologies—including bacterial genomics, metabolomics, anaerobic microbiology, bacterial genetics, gnotobiotic animal models, and patient cohort studies—to uncover the mechanisms by which gut microbiota influence disease pathogenesis and treatment response. A major driving force of the lab is the advancement of precision medicine for patients with rheumatic disease.

We seek highly talented and motivated candidates with strong backgrounds in microbiology, immunology, microbial genomics, computational biology, and/or murine models of inflammatory disease. Candidates will be expected to work independently and be active contributors to the collaborative multidisciplinary team of microbiologists, immunologists, and computational biologists who form the Nayak Lab. Candidates will be expected to push projects forward with creativity and rigor. The candidate will aid in ongoing research projects investigating the host-microbe-drug interactions and perform highly specialized as well as routine procedures to conduct well-designed, controlled experiments. The successful candidate will report directly to Dr. Renuka Nayak, MD, PhD but will work closely with collaborators within and outside of the group.

The Full Specialist will provide independent intellectual and technical contributions to ongoing projects, as well as lead their own research directions. The successful candidate will:

• Design, execute, and interpret experiments using a variety of methods, including anaerobic microbiology, microbial genomics, molecular biology, analytical chemistry, immunology, gnotobiology, and computational analysis.
• Develop, implement, optimize, and troubleshoot new assays, making innovative contributions to laboratory procedures
• Assist in maintaining and monitoring all equipment and procedures for quality control
• Review pertinent medical literature
• Contribute to data analysis (visualization and statistical analyses in R) and manuscript generation for publication in peer reviewed journals.
• Contribute substantially to publications, grant applications, and collaborative projects.
• Mentor and supervise junior specialists, students, and other trainees in the laboratory.
• Manage day-to-day lab operations, including oversight of compliance, safety, and procurement.
• Engage actively with the UCSF Benioff Center for Microbiome Medicine (BCMM) and collaborators across disciplines.
• Maintain a detailed written record of work performed
• Adhere to data security requirements
• Perform other duties as assigned (including with managing day-to-day lab operations, performing general lab duties, and being a positive lab citizen)

Required Qualifications:

• Terminal degree (PhD, MD, or equivalent) or ten or more years of research experience in a relevant field, such as Microbiology, Genomics, Immunology, Pharmacology or other related field.
• Demonstrated expertise in microbiome research, immunology, or related areas, evidenced by publications in peer-reviewed journals.
• Significant experience in standard laboratory techniques (such as microbiology and handling pathogenic strains, nucleic acid extraction, PCR, flow cytometry, analytical chemistry, mouse studies, etc.) is required.
• Working knowledge of safety standards in laboratories.
• Willingness and ability to learn new methods and skills for changing research priorities.
• Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.
• Ability to analyze data and perform statistical analyses.
• Ability to make sound decisions consistent with the essential job functions.
• Strong organizational and interpersonal communication skills (verbal and written).
• Excellent organizational skills, careful attention to detail, and ability to follow experimental protocols.
• Excellent time management and attention management skills.
• Ability to think creatively and to troubleshoot problems as they arise.
• Proven ability to work independently and as part of a collaborative team.
• Experience leading research projects, coordinating with collaborators, and mentoring trainees.

Preferred Qualifications:

• Prior experience with pathogenic microbes and aseptic techniques.
• Expertise in high-throughput sequencing and analysis or computational analysis of large datasets.
• Expertise with mass spectrometry or other analytical chemistry approaches.
• Expertise in immune profiling methods (e.g., flow cytometry).
• Prior experience in the design and assembly of DNA constructs.
• Expertise in bacterial genome manipulation and genetic engineering.
• Expertise working with gnotobiotic or conventional mouse models.

Appointment and Salary: This is a Full Specialist position. Specialists at this level are expected to have a significant record of academic accomplishments and to provide considerable independent input into research planning and execution. Depending on performance, opportunities for independent projects, mentorship, and scientific writing will be available.

Applicants must meet all requirements by the time of appointment.

Location: UCSF and the San Francisco VA Medical Center, overlooking the San Francisco Bay. Salary: See Table 24B for the salary range for this position. A reasonable estimate for this position is $93,200-$194,800.

Application: Please apply online at https://aprecruit.ucsf.edu/JPF05836. Applicants' materials must list current and/or pending qualifications upon submission.

• Curriculum Vitae - CV must clearly list current and/or pending qualifications (e.g. board eligibility/certification, medical licensure, etc.).
• Cover Letter
• Statement of Research (Optional)
• Statement of Teaching (Optional)

• 3-5 required (contact information only)

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

UCSF is committed to welcoming and serving all people, honoring the dignity of every individual without preference or prejudice, in support of its public mission and in alignment with its PRIDE values and Principles of Community.

As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct. • "Misconduct" means any violation of the policies or laws governing conduct at the applicant's previous place of employment, including, but not limited to, violations of policies or laws prohibiting sexual harassment, sexual assault, or other forms of harassment, or discrimination, as defined by the employer. • UC Sexual Violence and Sexual Harassment Policy • UC Anti-Discrimination Policy • APM - 035: Affirmative Action and Nondiscrimination in Employment

San Francisco, CA