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Internship Downstream Process Development Scientist Jobs in Sun Prairie, WI

MSCCN

Senior Data Scientist - Madison WI

Mcfarland, WI · On-site

$100K/yr

... development, and fill/finish processes. You will be responsible for model design, selection of ... The Data Sciences professional we seek is an individual with these qualifications. Basic ...

Illumina, Inc.

Sr Biochemistry Scientist

Madison, WI · On-site

$92K - $126K/yr

You are the Senior Biochemistry Scientist Illumina is looking for in joining our Test Method ... Work closely with Quality Control, Manufacturing, Quality Assurance, Process Development, and ...

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Internship Downstream Process Development Scientist information

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How much do internship downstream process development scientist jobs pay per hour?

As of Aug 19, 2026, the average hourly pay for internship downstream process development scientist in Sun Prairie, WI is $37.62, according to ZipRecruiter salary data. Most workers in this role earn between $27.60 and $44.90 per hour, depending on experience, location, and employer.

What does an internship downstream process development scientist do?

An Internship Downstream Process Development Scientist works in the biopharmaceutical industry, assisting with the development and optimization of processes that purify biological products such as proteins, antibodies, or vaccines after they are produced by cells. Their role often involves supporting laboratory experiments, analyzing samples, and documenting results to improve the efficiency and scalability of downstream processes like filtration and chromatography. Interns in this position gain hands-on experience with cutting-edge technologies and learn about regulatory requirements and industry standards. This role helps prepare students or recent graduates for a career in process development or biomanufacturing.

What types of projects and responsibilities can an internship downstream process development scientist expect to work on?

As an Internship Downstream Process Development Scientist, you can expect to be involved in hands-on laboratory work focusing on the purification and characterization of biopharmaceutical products. Typical responsibilities include preparing buffer solutions, operating chromatography and filtration systems, analyzing samples using various analytical techniques, and documenting experimental results. Interns often collaborate with experienced scientists and engineers, contributing to process optimization and troubleshooting. The role provides valuable exposure to industry-standard procedures and the opportunity to develop technical skills in a team-oriented environment.

What are the key skills and qualifications needed to thrive as an internship downstream process development scientist, and why are they important?

To thrive as an Internship Downstream Process Development Scientist, you need foundational knowledge in biochemistry, molecular biology, or chemical engineering, often supported by ongoing or recent enrollment in a relevant degree program. Familiarity with laboratory techniques such as chromatography, filtration, and analytical instruments, as well as experience with lab management software, is typically expected. Attention to detail, problem-solving abilities, and effective teamwork are standout soft skills in this role. These skills and qualifications are crucial for conducting reliable experiments, analyzing data, and contributing to the optimization of bioprocesses in a collaborative research environment.

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Internship Downstream Process Development Scientist jobs near you
Infographic showing various Internship Downstream Process Development Scientist job openings in Sun Prairie, WI as of June 2026, with employment types broken down into 16% As Needed, 29% Full Time, 29% Part Time, 12% Temporary, 1% Contract, and 13% Nights. Highlights an 85% Physical, 4% Hybrid, and 11% Remote job distribution, with an average salary of $78,244 per year, or $37.6 per hour.

Scientist III, Process Chemistry (Antibody-siRNA Conjugates)

Arrowhead Pharmaceuticals

Madison, WI • On-site

$110K - $125K/yr

Full-time

Re-posted 22 days ago

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead Pharmaceuticals is seeking a motivated Scientist III to join our Process Chemistry team, focused on the development and scale-up of conjugated RNAi therapeutics. This role centers on process development for antibody-siRNA conjugates (AOCs/ARCs), a key expansion of Arrowhead's TRiM platform into targeted extrahepatic delivery. The successful candidate will span the full development continuum - taking discovery-stage conjugation protocols, optimizing them for robustness and reproducibility, and developing them into GMP, kilogram-scale manufacturing processes. This is a hands-on role at the bench combined with oversight of external CRO/CDMO partners.
Responsibilities
  • Optimize discovery-stage conjugation protocols for antibody-siRNA conjugates, improving yield, reproducibility, and product quality to enable scale-up.
  • Develop GMP-ready, kilogram-scale conjugation processes, including site-specific and stochastic conjugation strategies, linker chemistry, and payload attachment.
  • Work hands-on in the laboratory to design, execute, and optimize conjugation reactions, purification (chromatography, TFF/UF-DF), and analytical control strategies.
  • Oversee and direct CROs/CDMOs executing process development and manufacturing activities, including setting technical direction, reviewing data, and ensuring timelines and quality standards are met.
  • Characterize conjugates for DAR/siRNA-to-antibody ratio, aggregation, charge heterogeneity, and stability using relevant analytical methods (e.g., HIC, SEC, IEX, LC-MS, AEX).
  • Lead technology transfer to internal and external manufacturing partners, authoring process descriptions, batch records, and development reports.
  • Troubleshoot process and analytical challenges; design experiments to define process parameters, ranges, and robustness for kilogram-scale operation.
  • Collaborate cross-functionally with discovery chemistry, linker/conjugation chemistry, analytical development, and CMC teams

Requirements
  • PhD in Organic Chemistry, Bioconjugate Chemistry, Chemical Engineering, or a related field; or a Bachelor's/Master's degree with commensurate hands-on industry experience.
  • Demonstrated hands-on experience in siRNA conjugation development is required.
  • Working knowledge of oligonucleotide and/or antibody chemistry, linker design, and bioconjugation methods.
  • Familiarity with purification and analytical characterization of conjugates.
  • Strong problem-solving, documentation, and communication skills.

Preferred
  • Experience with antibody-oligonucleotide conjugates (AOCs) or antibody-drug conjugates (ADCs).
  • Experience developing and scaling processes to GMP/kilogram scale and managing CRO/CDMO relationships.
  • Knowledge of site-specific conjugation technologies (e.g., engineered cysteines, enzymatic/click chemistry).
  • Experience with tech transfer and CMC/GMP environments.

Wisconsin pay range
$110,000-$125,000 USD
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
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