Encoded Therapeutics Jobs in Indiana (NOW HIRING)

Your Role:

Principal Research Scientist - Medicinal Chemist

Your Responsibilities:

• Guidethe design and optimization of novel small molecules by applying advanced synthetic strategies and integrating biological, pharmacological, and ADME/PK data to manage Structure-Activity Relationship (SAR) campaigns.

• Serve as a key medicinal chemistry figure on multidisciplinary project teams, collaborating with partners in Biology, Pharmacology, DMPK, Toxicology, and Computational Sciences to strategically advance discovery programs.

• Manage and coordinate synthetic chemistry efforts with external Contract Research Organizations (CROs) and internal partners, ensuring the efficient execution of project goals and timelines.

• Leveragecutting-edgedrug discovery technologies, including DNA-Encoded Libraries (DEL), computational chemistry, and AI/ML-enabled tools, to accelerate hit identification and lead optimization.

• Promote scientific excellence and data integrity while providing mentorship and technical guidance to junior scientists, fostering a culture of innovation and collaboration.

What You Need to Succeed (minimum qualifications):

• Education:PhD in Medicinal Chemistry, Organic Chemistry, ora relatedscientific discipline.

• Experience:A minimum of 6 years of relevant industry experience in medicinal chemistry within a pharmaceutical, biotechnology, or animal health research environment.

• Top Skills:Demonstratedexpertisein modern medicinal chemistry, including the design and multi-step synthesis of complex small molecules, and a strong understanding of Structure-Activity Relationships (SAR), pharmacology, and ADME/PK principles. Proven ability to autonomously manage scientific initiatives within a cross-functional team and manage external collaborations with CROs.

What will give you a strong candidate profile (preferred qualifications):

• Postdoctoral experience.

• Experience applying modern drug discovery technologies such as DNA-Encoded Libraries (DEL), computational chemistry, or AI/ML-enabled molecular design.

• A strongtrack recordof advancing small-molecule discovery programs toward preclinical development,evidencedby significant patent and/or publication contributions.

• Prior research experience in the animal health industry.

• Expertise inpeptide chemistry, macrocycles, or related drug modalities.

Additional Information:

• Travel:Less than 10%

• Location:Global Elanco Headquarters - Indianapolis, IN - Hybrid Work Environment

Don'tmeet every single requirement? Studies have shown underrecognized groups are less likely to applytojobs unless they meet every single qualification. At Elanco we are dedicated to building a diverse and inclusive work environment. If you think you might be a good fit for a role butdon'tnecessarily meet every requirement, we encourage you to apply. You may be the right candidate for this role or other roles!

Elanco Benefits and Perks:

We offer a comprehensive benefits package focusing on financial, physical, and mental well-being while encouraging our employees to pursue our purpose! Some highlights include:

• Multiple relocation packages

• Two weeklong shutdowns (mid-summer and year-end) in the US (in addition to PTO)

• 8-week parental leave

• 9 Employee Resource Groups

• Annual bonus offering

• Flexible work arrangements

• Up to 6% 401K matching