Legend Biotech is seeking a VP, Head of Preclinical Development as part of the Early Drug Development team based in Somerset, NJ . Role Overview Legend Biotech is a clinical-stage biotech company ...
Legend Biotech is seeking a VP, Head of Preclinical Development as part of the Early Drug Development team based in Somerset, NJ . Role Overview Legend Biotech is a clinical-stage biotech company ...
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Senior Director, Advanced Pharmacometrics, Quantitative Pharmacology and Pharmacometrics - Immuno-On
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Director, Quantitative Pharmacology and Pharmacometrics - Oncology
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Directors are leaders in the field of quantitative drug development, with a strong, integrated understanding of the strategic elements of drug development. As a subject matter expert, the Director ...
Director, Quantitative Pharmacology and Pharmacometrics - Oncology
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Medical
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Directors are leaders in the field of quantitative drug development, with a strong, integrated understanding of the strategic elements of drug development. As a subject matter expert, the Director ...
Director, Quantitative Pharmacology and Pharmacometrics - Oncology
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Medical
Dental
Vision
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PTO
Directors are leaders in the field of quantitative drug development, with a strong, integrated understanding of the strategic elements of drug development. As a subject matter expert, the Director ...
Senior Director, Advanced Pharmacometrics, Quantitative Pharmacology and Pharmacometrics - Immuno...
Medical
Dental
Vision
Retirement
PTO
Our Senior Directors are recognized experts in quantitative drug development and possess a deep, integrated understanding of both the science and the strategic, endtoend dimensions of oncology drug ...
Senior Director, Advanced Pharmacometrics, Quantitative Pharmacology and Pharmacometrics - Immuno...
Medical
Dental
Vision
Retirement
PTO
Our Senior Directors are recognized experts in quantitative drug development and possess a deep, integrated understanding of both the science and the strategic, endtoend dimensions of oncology drug ...
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Medical
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Maintain a high level of technical and application competence of Chemistry services for drug discovery and development and utilize this knowledge to achieve sales targets. * Promote and maintain high ...
Business Development Manager - Drug Discovery
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Medical
Dental
Vision
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Maintain a high level of technical and application competence of Chemistry services for drug discovery and development and utilize this knowledge to achieve sales targets. * Promote and maintain high ...
Senior Director, Advanced Pharmacometrics, Quantitative Pharmacology and Pharmacometrics - Immuno-On
Rahway, NJ · On-site +1
Medical
Dental
Vision
Retirement
PTO
Our Senior Directors are recognized experts in quantitative drug development and possess a deep, integrated understanding of both the science and the strategic, end-to-end dimensions of oncology drug ...
Senior Director, Advanced Pharmacometrics, Quantitative Pharmacology and Pharmacometrics - Immuno-On
Rahway, NJ · On-site +1
Medical
Dental
Vision
Retirement
PTO
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Senior Associate, Investments (9770332)
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Business Development Manager - Drug Discovery
Medical
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Maintain a high level of technical and application competence of Chemistry services for drug discovery and development and utilize this knowledge to achieve sales targets. * Promote and maintain high ...
Business Development Manager - Drug Discovery
Medical
Dental
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Maintain a high level of technical and application competence of Chemistry services for drug discovery and development and utilize this knowledge to achieve sales targets. * Promote and maintain high ...
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Director - Pharmacometrics AI Lead (Remote or Hybrid)
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Associate Director, Quantitative Pharmacology and Pharmacometrics - Immuno-Oncology (QP2‐IO)
Rahway, NJ · On-site
$156.90 - $247/hr
Medical
Dental
Vision
Retirement
PTO
Associate Directors are emerging leaders in the field of quantitative drug development, with a developing understanding of the strategic elements of drug development and effective communication ...
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Our Senior Directors are recognized experts in quantitative drug development and possess a deep, integrated understanding of both the science and the strategic, end‑to‑end dimensions of oncology ...
Senior Director, Advanced Pharmacometrics, Quantitative Pharmacology and Pharmacometrics - Immu[...]
Rahway, NJ · On-site
$210.40 - $331.10/hr
Medical
Dental
Vision
Retirement
PTO
Our Senior Directors are recognized experts in quantitative drug development and possess a deep, integrated understanding of both the science and the strategic, end‑to‑end dimensions of oncology ...
Director - Pharmacometrics AI Lead (Remote or Hybrid)
Rahway, NJ · On-site +1
Medical
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Director - Pharmacometrics AI Lead (Remote or Hybrid)
Rahway, NJ · On-site +1
Medical
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Principal Data Scientist
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Principal Data Scientist
$204K - $267K/yr
In this role, you'll lead crucial initiatives that directly impact our drug development portfolio, from developing sophisticated models for patient selection to creating AI-powered solutions for ...
Associate Director, Quantitative Pharmacology and Pharmacometrics - Immuno-Oncology (QP2‑IO)
Rahway, NJ · On-site
Medical
Dental
Vision
Retirement
PTO
Associate Directors are emerging leaders in the field of quantitative drug development, with a developing understanding of the strategic elements of drug development and effective communication ...
Associate Director, Quantitative Pharmacology and Pharmacometrics - Immuno-Oncology (QP2‑IO)
Rahway, NJ · On-site
Medical
Dental
Vision
Retirement
PTO
Associate Directors are emerging leaders in the field of quantitative drug development, with a developing understanding of the strategic elements of drug development and effective communication ...
Director - Pharmacometrics AI Lead (Remote or Hybrid)
Rahway, NJ · On-site
Medical
Dental
Vision
Retirement
PTO
As we enter a new era of AI-driven drug development, our mission is to amplify MIDD through cutting-edge AI, advanced analytics, and automation. With AI/ML now integral to decision-making at our ...
Director - Pharmacometrics AI Lead (Remote or Hybrid)
Rahway, NJ · On-site
Medical
Dental
Vision
Retirement
PTO
As we enter a new era of AI-driven drug development, our mission is to amplify MIDD through cutting-edge AI, advanced analytics, and automation. With AI/ML now integral to decision-making at our ...
Sr. Principal Scientist (Sr. Director) - Regulatory Liaison
Rahway, NJ · On-site
$190.80 - $300.30/hr
Medical
Dental
Vision
Retirement
PTO
S., with minimum of 10 years relevant drug development experience, with a majority in regulatory affairs * M.S. with minimum of 10 years relevant drug development experience, with a majority in ...
Sr. Principal Scientist (Sr. Director) - Regulatory Liaison
Rahway, NJ · On-site
$190.80 - $300.30/hr
Medical
Dental
Vision
Retirement
PTO
S., with minimum of 10 years relevant drug development experience, with a majority in regulatory affairs * M.S. with minimum of 10 years relevant drug development experience, with a majority in ...
Associate Director, Quantitative Pharmacology and Pharmacometrics - Immuno-Oncology (QP2IO)
Rahway, NJ · On-site +1
Medical
Dental
Vision
Retirement
PTO
Associate Directors are emerging leaders in the field of quantitative drug development, with a developing understanding of the strategic elements of drug development and effective communication ...
Associate Director, Quantitative Pharmacology and Pharmacometrics - Immuno-Oncology (QP2IO)
Rahway, NJ · On-site +1
Medical
Dental
Vision
Retirement
PTO
Associate Directors are emerging leaders in the field of quantitative drug development, with a developing understanding of the strategic elements of drug development and effective communication ...
Director - Pharmacometrics AI Lead (Remote or Hybrid)
Rahway, NJ · On-site +1
Medical
Dental
Vision
Retirement
PTO
As we enter a new era of AI-driven drug development, our mission is to amplify MIDD through cutting-edge AI, advanced analytics, and automation. With AI/ML now integral to decision-making at our ...
Director - Pharmacometrics AI Lead (Remote or Hybrid)
Rahway, NJ · On-site +1
Medical
Dental
Vision
Retirement
PTO
As we enter a new era of AI-driven drug development, our mission is to amplify MIDD through cutting-edge AI, advanced analytics, and automation. With AI/ML now integral to decision-making at our ...
VP, Head of Preclinical Development
Somerset, NJ · On-site
Medical
Dental
Vision
Life
Retirement
PTO
Legend Biotech is seeking a VP, Head of Preclinical Development as part of the Early Drug Development team based in Somerset, NJ . Role Overview Legend Biotech is a clinical-stage biotech company ...
VP, Head of Preclinical Development
Somerset, NJ · On-site
Medical
Dental
Vision
Life
Retirement
PTO
Legend Biotech is seeking a VP, Head of Preclinical Development as part of the Early Drug Development team based in Somerset, NJ . Role Overview Legend Biotech is a clinical-stage biotech company ...
Drug Development information
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| Aspect | Drug Development | Pharmacologist |
|---|---|---|
| Required Credentials | Bachelor's or Master's in Pharmaceutical Sciences, Chemistry, or related fields; often requires experience in clinical trials | Degree in Pharmacology, Pharmacy, or related fields; may require licensing or certification for clinical practice |
| Work Environment | Research labs, pharmaceutical companies, clinical trial sites | Research labs, hospitals, academic institutions, regulatory agencies |
| Industry Usage | Developing new drugs, overseeing clinical trials, regulatory submissions | Studying drug effects, mechanisms, safety, and efficacy; advising on drug use |
While both roles are integral to the pharmaceutical industry, Drug Development focuses on creating and bringing new drugs to market through research, testing, and regulatory processes. Pharmacologists primarily study how drugs interact with biological systems, often working in research or clinical settings to understand drug effects and safety. The two roles often collaborate but differ in their core responsibilities and career focus.
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Full-time
Posted 27 days ago
Job description
Legend Biotech is seeking a VP, Head of Preclinical Development as part of the Early Drug Development team based in Somerset, NJ.
Role Overview
Legend Biotech is a clinical-stage biotech company developing cell therapies for hematological malignancies, solid tumors and autoimmune diseases. We are seeking an exceptional scientist-leader to serve as Vice President, Head of Preclinical Development. This is a senior, externally visible leadership role accountable for the full preclinical development program across in vitro pharmacology, in vivo pharmacology, and toxicology for all pipeline compounds globally. The person will build and lead a high-performing, integrated team, set scientific standards for the organization, and serve as the internal authority and external face for preclinical science across regulatory, partnership, and publication contexts.
Key Responsibilities
- Define and execute the preclinical development strategy across all pipeline program globally from candidate nomination through IND-enabling studies.
- Serve as the internal scientific authority on in vitro pharmacology, in vivo pharmacology, and toxicology - setting methodological standards, experimental design principles, and data interpretation frameworks.
- Lead preclinical science for novel modalities including lentiviral vector-based in vivo CAR-T, ex vivo cell therapies, and gene-modified immune cell platforms, with deep understanding of the unique preclinical characterization requirements of each
- Integrate preclinical datasets (PK, PD, safety, biodistribution etc) into coherent compound narratives that inform clinical development strategy, dose selection, and regulatory submissions.
- Contribute to portfolio decisions by providing rigorous preclinical risk assessments for new candidates, partnership assets, and lifecycle management opportunities.
- Own the preclinical component of IND applications, accountable for integrated pharmacology and toxicology summaries, study tabulations, and the Written Summary of nonclinical pharmacology and toxicology.
- Build, lead, and develop a high-performing Preclinical Development team comprising in vitro pharmacology scientists, in vivo pharmacology scientists, and toxicologists - both internal staff and embedded CRO personnel.
- Set a culture of scientific excellence, objectivity, and regulatory integrity - where data are interpreted accurately regardless of programme pressure and where safety signals are escalated promptly and without bias.
- Mentor and develop team members at all levels; create individual development plans, provide regular performance feedback, and support career progression.
Requirements
- PhD in pharmacology, toxicology, immunology, cell biology, or a closely related discipline.
- Minimum 15 years of progressive experience in preclinical drug development, with at least 5 years in a senior leadership role with direct accountability for IND-enabling programs.
- Deep expertise in at least two of the three core functions (in vitro pharmacology, in vivo pharmacology, toxicology), with working knowledge of the third.
- Demonstrated experience designing, overseeing, and interpreting GLP toxicology studies (repeat-dose NHP or rodent, safety pharmacology, genotoxicity) in support of IND filing.
- Experience in cell therapy, gene therapy, or advanced therapy development.
- Track record of successful IND submissions with clear accountability for the nonclinical pharmacology and toxicology sections.
- Experience managing CRO relationships for outsourced preclinical and GLP studies, including vendor qualification, protocol development, monitoring, and report review.
- Proven ability to lead, mentor, and build high-performing scientific teams in a fast-paced biotech environment.
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