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Downstream Process Jobs in Texas (NOW HIRING)

Lonza

Scientist II, Downstream

Houston, TX · On-site

Scientist II, Downstream Location: This is an on-site position located in Pearland, TX. The purpose ... The ideal candidate will be responsible for leading new process development and improving existing ...

Lonza

Scientist II, Downstream

Houston, TX

Scientist II, Downstream Location: This is an on-site position located in Pearland, TX. The purpose ... The ideal candidate will be responsible for leading new process development and improving existing ...

Ecolab

Marketing Director - Downstream PLM

Houston, TX · On-site

$142K - $214K/yr

Downstream sits within Ecolab's Global Water division, and is focused on serving customers in the ... Our teams work on customer sites to provide process and water solutions across the entire value ...

Ecolab

Marketing Director - Downstream PLM

Houston, TX · On-site

$142K - $214K/yr

Downstream sits within Ecolab's Global Water division, and is focused on serving customers in the ... Our teams work on customer sites to provide process and water solutions across the entire value ...

Downstream System Inc

Account Manager

Richardson, TX · On-site

$10K - $100K/mo

In this role, you'll work with current customers to help them get the most value from Downstream ... sales process, and grow your career in account management. What You'll Do Manage and grow a ...

MaverickX

Senior Bio Process Engineer

Austin, TX · On-site

$103K - $133K/yr

You will oversee reactor performance, downstream processing, and plant operations, ensuring that every batch meets defined quality and yield targets. You will define and control cost per liter ...

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Downstream Process information

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How much do downstream process jobs pay per hour?

As of Jun 12, 2026, the average hourly pay for downstream process in Texas is $22.99, according to ZipRecruiter salary data. Most workers in this role earn between $18.37 and $26.20 per hour, depending on experience, location, and employer.

What are some common challenges faced by professionals working in downstream process roles within biomanufacturing?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What are the key skills and qualifications needed to thrive as a Downstream Process Engineer, and why are they important?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What is a Downstream Process in biotechnology?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.
What are popular job titles related to Downstream Process jobs in Texas? For Downstream Process jobs in Texas, the most frequently searched job titles are:
What job categories do people searching Downstream Process jobs in Texas look for? The top searched job categories for Downstream Process jobs in Texas are:
What cities in Texas are hiring for Downstream Process jobs? Cities in Texas with the most Downstream Process job openings:
Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Texas as of June 2026, with employment types broken down into 3% Locum Tenens, 42% Full Time, 49% Part Time, 3% Temporary, and 3% Contract. Highlights an 93% Physical, 3% Hybrid, and 4% Remote job distribution, with an average salary of $47,811 per year, or $23 per hour.

Scientist II, Downstream

Lonza

Houston, TX • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 8 days ago

Lonza rating

8.1

Company rating: 8.1 out of 10

Based on 40 frontline employees who took The Breakroom Quiz

31st of 71 rated pharmaceutical

Job description

Scientist II, Downstream
Location: This is an on-site position located in Pearland, TX.
The purpose of this role is to work in a high performing, cross functional team with the goal of driving innovation in the development of scalable downstream processes related to the manufacture of therapeutic gene therapy products. The ideal candidate will be responsible for leading new process development and improving existing processes. The incumbent will independently design and coordinate the execution of experiments related to the purification of viral based gene therapy products, and be an excellent communicator.
What you will get:
A competitive compensation. In addition, below you will find a comprehensive summary of the benefits package we offer:
  • Performance-related bonus.
  • Medical, dental and vision insurance.
  • 401(k) matching plan.
  • Life insurance, as well as short-term and long-term disability insurance.
  • Employee assistance programs.
  • Paid time off (PTO).

Compensation for this role will be determined by the candidate's qualifications, skills, experience, and relevant knowledge.
What you will do:
  • Interacts with clients regarding process development scopes and tech transfer activities as well as data discussion and challenge resolutions.
  • Responsible for tech transfer to manufacturing following Lonza guidelines, provides ongoing supports as needed.
  • Designs and executes experiments, analyzes data. Authoring study protocols and reports. Maintains accurate & detailed records following Lonza's best documentation practices.
  • Contributes and supports scientific and engineering expertise toward the design and development of new downstream process ideas that support client product concepts.
  • Establish collaborative relationships and serve as SME to cross-functional groups (MSAT, MFG, QC, and PM).
  • Mentor and train junior colleagues.

What we are looking for:
  • PhD or MS in Life Sciences with focus on biology or bioengineering
  • Experience with development and optimization of viral or protein purification process including chromatography, filtration and formulation unit operations.
  • Experience with the technology transferring of viral or protein related downstream processes to cGMP manufacturing.
  • Experience or knowledge of analytical methods and in process controls commonly used in manufacturing processes.
  • Experience with late-stage process development for viral or protein related downstream process is highly desirable.

About Lonza:
At Lonza, our people are our greatest strength. With 30+ sites across five continents, our globally connected teams work together every day to manufacture the medicines of tomorrow. Our core values of Collaboration, Accountability, Excellence, Passion and Integrity reflect who we are and how we work together. Everyone's ideas, big or small, have the potential to improve millions of lives, and that's the kind of work we want you to be part of.
Innovation thrives when people from all backgrounds bring their unique perspectives to the table. At Lonza, we offer equal employment opportunities to all qualified applicants regardless of race, religion, color, national origin, sex, sexual orientation, gender identity, age, disability, veteran status, or any other characteristic protected by law. If you're ready to help turn our customers' breakthrough ideas into viable therapies, we look forward to welcoming you on board.
Ready to shape the future of life sciences? Apply now.

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