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Dna Synthesis Operations Engineer Jobs (NOW HIRING)

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Mechatronics Engineer

Louisville, KY · On-site

This role is ideal for an engineer who enjoys working across mechanical, electrical, controls, and ... DNA/RNA synthesis operations. Key Responsibilities * Design, develop, and maintain automated ...

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How much do dna synthesis operations engineer jobs pay per year?

As of Sep 10, 2026, the average yearly pay for dna synthesis operations engineer in the United States is $85,029.00, according to ZipRecruiter salary data. Most workers in this role earn between $69,500.00 and $94,000.00 per year, depending on experience, location, and employer.

What does a DNA Synthesis Operations Engineer do?

A DNA Synthesis Operations Engineer is responsible for managing and optimizing the processes involved in synthesizing DNA sequences in a laboratory or industrial setting. They oversee equipment, troubleshoot technical issues, and ensure quality control throughout the synthesis workflow. Their role often involves automating processes, maintaining compliance with safety and regulatory standards, and collaborating with scientists to improve efficiency and accuracy. This position is critical in biotechnology companies that produce custom DNA for research, diagnostics, or therapeutic applications.

What are the key skills and qualifications needed to thrive as a DNA Synthesis Operations Engineer?

A DNA Synthesis Operations Engineer needs a solid background in molecular biology, chemistry, and laboratory techniques, often supported by a degree in a life science or engineering field. Familiarity with automated DNA synthesizers, liquid handling robots, and quality control software is typically required, along with experience in GMP or ISO-regulated environments. Strong problem-solving, attention to detail, and effective communication are crucial soft skills for success in this role. These skills and qualifications ensure the accurate, efficient, and compliant production of synthetic DNA, which is vital for research and industrial applications.

What are some common challenges faced by DNA Synthesis Operations Engineers, and how are they typically addressed within the team?

DNA Synthesis Operations Engineers often face challenges such as maintaining high accuracy in complex synthesis protocols, troubleshooting equipment malfunctions, and managing tight production timelines. To address these, teams typically implement rigorous quality control procedures, foster a collaborative environment for rapid problem-solving, and use automation to streamline repetitive tasks. Regular cross-functional meetings with quality assurance and R&D teams also help ensure that any issues are quickly identified and resolved, supporting both product quality and operational efficiency.

What are popular job titles related to Dna Synthesis Operations Engineer jobs?

For Dna Synthesis Operations Engineer jobs, the most frequently searched job titles are:

Infographic showing various Dna Synthesis Operations Engineer job openings in the United States as of September 2026, with employment types broken down into 87% Full Time, and 13% Part Time. Highlights an 87% In-person, and 13% Remote job distribution, with an average salary of $85,029 per year, or $40.9 per hour.

Research Associate, Supervisor Synthesis Production

South San Francisco, CA • On-site

Mammoth DS, Inc
See more jobs at Mammoth DS, Incexternal

Other

Posted 8 days ago

Key responsibilities

  • Supervise the building and operation of the production team and lab for DNA synthesis.

  • Perform on-chip DNA synthesis runs, including reagent preparation, chip handling, DNA extraction, PCR, aliquotting, and encapsulation.

  • Develop, implement, and train others on SOPs for production processes, and analyze QC data to ensure sample quality.

Job description

Research Associate, Supervisor Synthesis Production About this position

Atlas Data Storage is an information technology company building data storage products leveraging the unique properties of synthetic DNA. We are seeking a highly motivated Research Associate to supervise the building of our production team and lab dedicated to advancing our massively parallel semiconductor-based DNA synthesis platform. This position will engage in hands‑on, bench‑level work, and collaborate closely with our Synthesis and Engineering team to provide the early‑stage production of DNA for data storage applications to help develop new customers and products.

Essential Duties and Responsibilities
  • Directly support the Atlas’s CMOS chip‑based DNA synthesis, including both Phosphoramidite and Enzymatic workflows as required to support product and customer development needs. This will entail working with scientists, engineers, and business development staff on a daily basis.
  • Perform regular on‑chip DNA synthesis runs for customers, encompassing reagent preparation, chip handling, extraction of DNA, and post extraction PCR, aliquotting and encapsulation.
  • Responsible for leading operation of all hardware and managing limited scale production, growing team as business demands. Engineering and Biochemistry will provide needed training and support to assure ongoing success.
  • Develop and help analyze QC data, utilize data to ensure that completed samples are all of adequate quality before shipment.
  • Develop and implement SOPs for production process. Train and manager RAs and Operators to execute the SOPs effectively. Develop processes to reduce turnaround time and optimize production.
Qualifications
  • Bachelor’s degree in Biomedical Engineering, Bioengineering, Chemical Engineering, Chemistry, Molecular Biology or another relevant field. 5+ years work experience in an industry setting is desirable.
  • Prior experience with custom instrumentation within a workflow: running experiments to characterize either the instrument, chip, or other modules involved in the process. Comfortable in learning to operate new hardware.
  • Experience in using a range of automated liquid handlers.
  • Experience in research or production of solid phase oligonucleotide (DNA) synthesis (phosphoramidite and/or enzymatic).
  • Experience with laboratory techniques including DNA characterization (Qubit, Nanodrop, Bioanalyzer, CE), PCR, qPCR, LCMS, NGS, DNA hybridization assay experience – preferred.
  • Knowledge of silicon processing techniques or electrochemistry – a plus.
  • Understanding of micro‑scale processes, physics, chemistry, surface chemistry development – a plus.
  • Self‑learner, self‑starter, with the ability to grasp concepts and techniques on the go. Desire to wear multiple hats within a small unit and develop a well‑rounded multi‑disciplinary profile.
  • Experience in effectively managing and training small groups of research associates and operators to develop and maintain production efficiency while ensuring compliance with SOPs and institutional procedures.

Pay range: 75,000 - 110,000 USD per year (HQ)

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