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Director Nonmem Jobs (NOW HIRING)

Iambic Therapeutics, Inc

$164K - $245K/yr

JOB SUMMARY The Associate Director/Director will be responsible for designing and executing ... NONMEM, R) and current regulatory frameworks (e.g., ICH M12, FDA DDI guidance). * Write and review ...

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Infographic showing various Director Nonmem job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 85% Full Time, 12% Part Time, 1% Temporary, and 1% Contract. Highlights an 92% Physical, 3% Hybrid, and 5% Remote job distribution.

Director Clinical Pharmacology & DMPK

Alumis

South San Francisco, CA

$200K - $240K/yr

Full-time

Re-posted 15 days ago

Job description

Alumis is seeking a Director of Clinical Pharmacology & DMPK to drive clinical pharmacology strategy and PK/PD modeling for our small-molecule programs in immune-mediated diseases. This role partners closely with cross-functional teams and reports to the Head of Clinical Pharmacology & DMPK.

Specific responsibilities include but are not limited to:
  • Lead clinical pharmacology strategy, dose selection, and PK/PD and biomarker planning across early and late-stage programs.
  • Conduct and interpret PK, PK/PD, exposure-response, and simulation analyses using tools such as NONMEM, WinNonlin, R, Python, and Simcyp.
  • Integrate translational and nonclinical PK/PD data to support FIH dose projections and DDI assessments.
  • Oversee bioanalytical CROs, ensuring high-quality PK/PD/biomarker data and GLP/GCP compliance.
  • Partner with Clinical Operations on sample management and protocol design.
  • Communicate quantitative findings clearly and contribute to regulatory documents (protocols, IBs, INDs, NDAs, IMPDs).
  • Collaborate across Clinical Development, Biostats/Data Science, Nonclinical, and Program Management.
Key Requirements and Qualifications:
  • PhD, PharmD, or equivalent in Pharmacokinetics, Pharmacology, or related field.
  • 6 to 8+ years of industry experience in Clinical Pharmacology, DMPK, or Quantitative Pharmacology.
  • Strong expertise in PK, PK/PD, DMPK, and translational sciences.
  • Proficiency with modeling/simulation platforms (NONMEM, WinNonlin, Simcyp, R, Python).
  • Excellent communication, organization, and ability to work independently in a fast-paced environment.

The salary range for this position is $200,000 USD to $240,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company's compensation practices.   

This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday. 

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