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Crispr Base Editing Jobs (NOW HIRING)

Prime Medicine

Informatics Engineer

Cambridge, MA · On-site

CRISPR, base editing, prime editing. * GxP / 21 CFR Part 11 / regulated-software experience. * Plotly Dash, Streamlit, Spotfire, Retool, or similar tools for internal apps and data visualizations.

Prime Medicine

Informatics Engineer

Cambridge, MA · On-site

CRISPR, base editing, prime editing. * GxP / 21 CFR Part 11 / regulated-software experience. * Plotly Dash, Streamlit, Spotfire, Retool, or similar tools for internal apps and data visualizations.

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Crispr Base Editing information

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$80K

$107.2K

$146K

How much do crispr base editing jobs pay per year?

As of Sep 9, 2026, the average yearly pay for crispr base editing in the United States is $107,166.00, according to ZipRecruiter salary data. Most workers in this role earn between $87,500.00 and $138,000.00 per year, depending on experience, location, and employer.

What is CRISPR base editing?

CRISPR base editing is a precise genome editing technique that enables scientists to directly convert one DNA base into another without making double-stranded breaks in the DNA. Unlike traditional CRISPR methods that cut DNA, base editing uses modified enzymes to chemically alter a single nucleotide, allowing for targeted changes with fewer unintended effects. This method is highly valuable for studying genes and for developing therapies for genetic diseases caused by point mutations.

What are the key skills and qualifications needed to thrive as a CRISPR base editing scientist?

To thrive as a CRISPR Base Editing Scientist, you need a strong background in molecular biology, genetics, and gene-editing technologies, typically supported by an advanced degree (PhD or MSc) in a relevant field. Familiarity with gene-editing tools (such as CRISPR-Cas systems), next-generation sequencing (NGS), and bioinformatics platforms is essential. Attention to detail, critical thinking, and effective collaboration are vital soft skills for experimental design and problem-solving in interdisciplinary teams. These skills ensure precise genome editing, robust data analysis, and successful research outcomes in this rapidly evolving field.

What are some typical challenges faced by professionals working in CRISPR base editing roles?

Professionals in CRISPR base editing often encounter challenges such as optimizing editing efficiency, minimizing off-target effects, and ensuring the fidelity of base conversions. Working with complex biological systems requires rigorous experimental design and troubleshooting to achieve precise genetic modifications. Additionally, collaboration with multidisciplinary teams—including molecular biologists, bioinformaticians, and regulatory experts—is vital to address technical hurdles and advance research or therapeutic projects.

What is the difference between Crispr Base Editing vs Crispr Gene Editing Specialist?

AspectCrispr Base EditingCrispr Gene Editing Specialist
Required CredentialsBiology or related degree, lab experience, molecular biology certificationsBiology or related degree, lab experience, molecular biology certifications
Work EnvironmentResearch labs, biotech companies, academic institutionsResearch labs, biotech companies, academic institutions
Industry UsagePrecise DNA base modifications, gene correctionGene editing, modification, and research

Both roles require similar educational backgrounds and work environments, focusing on genetic research. However, Crispr Base Editing specializes in precise nucleotide changes, while Crispr Gene Editing Specialists may work on broader gene modification projects. Understanding these differences helps in choosing the right career path or job search focus.

What other helpful pages are available for Crispr Base Editing?

Other pages related to Crispr Base Editing:

Infographic showing various Crispr Base Editing job openings in the United States as of September 2026, with employment types broken down into 1% As Needed, 87% Full Time, 11% Part Time, and 1% Contract. Highlights an 90% Physical, 2% Hybrid, and 8% Remote job distribution, with an average salary of $107,166 per year, or $51.5 per hour.

Scientist II - Sr. Scientist, CRISPR Specificity & Genomic Safety

Emeryville, CA • On-site

Profluent
See more jobs at Profluentexternal

$105K - $144K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 8 days ago

Key responsibilities

  • Build and lead the strategy for base editor specificity assessment, including off-target discovery and validation workflows

  • Develop, optimize, benchmark, and apply methods to evaluate editing specificity across different experimental systems

  • Design and execute studies to identify, prioritize, and validate potential off-target editing events, and generate decision-enabling datasets

Job description

Profluent is the frontier AI lab for biology. Profluent builds powerful foundation models for all of life's molecules, unlocking solutions that transform medicine, agriculture, and beyond. Founded in 2022 and headquartered in Emeryville, CA, Profluent is backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures and has raised over $150M to date.
Profluent is seeking a creative and enthusiastic Scientist II - Sr. Scientist to build and apply experimental workflows that characterize the specificity, safety, and developability of our personalized CRISPR base editing platform. This role will initially focus on establishing and scaling base-editor specificity workflows, including biochemical and cell-based approaches such as CHANGE-seq-BE and related methods for identifying DNA and RNA off-target activity. In the longer term, the candidate will spearhead off-target assessments for novel gene editing platforms such as engineered recombinases.
The candidate will work closely with protein engineering, cell biology, bioinformatics, automation, and program teams to generate decision-quality datasets that guide editor design, candidate selection, and therapeutic program development. This person will be responsible for benchmarking assays, interpreting NGS-based specificity data, identifying limitations and opportunities across methods, and building robust workflows that can be deployed across editing modalities and disease-relevant contexts.
This is an excellent opportunity to shape how AI-designed genome editing systems are evaluated and advanced, and to work cross-functionally with a diverse team of experts across machine learning, protein engineering, cell biology, genomics, and gene editing.
Responsibilities
  • Build and lead Profluent's strategy for base editor specificity assessment, with an emphasis on base-editor-relevant off-target discovery and validation workflows such as CHANGE-Seq-BE and related biochemical, cell-based, and targeted sequencing approaches
  • Develop, optimize, benchmark, and apply orthogonal methods to evaluate editing specificity, including workflows for base editors, nucleases, and broader genomic integrity assessment across relevant experimental systems
  • Design and execute studies to identify, prioritize, and validate potential off-target editing events, integrating assay development, NGS library preparation, sequencing QC, and data interpretation in partnership with computational biology and program teams
  • Generate high-quality, decision-enabling datasets that inform editor engineering, guide/editor selection, delivery conditions, candidate nomination, and program development strategy
  • Collaborate cross-functionally with protein engineering, cell biology, gene editing, bioinformatics, automation, and program teams to integrate specificity workflows into Profluent's broader R&D infrastructure
  • Establish robust experimental processes, documentation, and analysis frameworks to support reproducibility, scalability, assay qualification, and potential regulatory-facing genomic safety packages
  • Present results and clearly communicate experimental strategy, timelines, risks, milestones, and program implications to diverse scientific and company stakeholders
  • Provide mentorship and guidance to junior team members and peers, helping align goals, troubleshoot experiments, and maintain high standards for execution and interpretation
  • Stay current with emerging technologies in CRISPR specificity, base editing, off-target discovery, targeted validation, genomic integrity assessment, and therapeutic genome editing

Qualifications
  • PhD (or equivalent) in molecular biology, genomics, genome editing, biochemistry, bioengineering, genetics, chemical biology, or a related field with 2-4 years of relevant industry experience in genome editing specificity and genomic safety assessment
  • Deep expertise and hands-on experience with CRISPR-based genome editing systems, particularly base editors, and a strong understanding of modality-specific specificity risks such as DNA off-target editing, RNA off-target editing, bystander editing, indels, and unintended editing outcomes
  • Hands-on experience developing, optimizing, or applying NGS-based workflows for genome editing analysis, such as CHANGE-seq, CHANGE-seq-BE, GUIDE-seq, SITE-seq, CIRCLE-seq, Digenome-seq, DISCOVER-seq, INDUCE-seq, targeted amplicon sequencing, rhAmpSeq/AmpSeq-like workflows, hybrid capture, RNA-seq, WGS, or related approaches
  • Strong experimental background in molecular biology, mammalian cell culture, genome editing reagent delivery, NGS library preparation, assay troubleshooting, and quantitative analysis of editing outcomes
  • Experience interpreting complex sequencing datasets and collaborating with bioinformatics or computational biology teams to analyze off-target discovery, targeted validation, variant calling, RNA editing, indel profiles, or genomic integrity data
  • Ability to design rigorous experiments with appropriate controls, replicates, sensitivity considerations, and clear decision criteria
  • Experience with high-throughput or semi-automated workflows, process development, assay qualification, data tracking, and reproducible execution in a fast-paced research environment
  • High level of attention to detail and commitment to generating high-quality, decision-enabling data
  • Experience with cross-functional collaboration in a biotechnology setting, particularly with protein engineering, cell biology, computational biology, translational, or program teams
  • Excellent communication skills and ability to present complex scientific concepts, datasets, limitations, and recommendations to colleagues and stakeholders
  • Strong track record of managing complex projects, mentoring junior scientists, and driving workstreams from exploratory development through implementation

Preferences
  • Experience with therapeutic genome editing programs and genomic safety packages for candidate nomination, IND-enabling studies, or regulatory-facing documentation
  • Experience working with disease-relevant primary cells, ex vivo edited cells, iPSC-derived systems, or other therapeutically relevant model systems
  • Familiarity with ML-guided enzyme engineering campaigns and how specificity datasets can inform editor design, model evaluation, and candidate prioritization
  • Expertise in protein purification of genome editors for use in biochemical off-target assays

What We Offer
  • High-growth opportunity with meaningful impact on the future of protein design
  • Competitive compensation package with equity participation
  • 401(k) with a strong employer match
  • Comprehensive benefits including health/dental/vision insurance
  • Generous PTO policy and commitment to work-life balance
  • Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.
Work Authorization Requirement
Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.
Employment Eligibility Verification
Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.
Hiring Salary Range
$147,000-$177,000 USD

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