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Associate Scientist I (Contract), Research

Vaxcyte

San Carlos, CA

$40 - $45/hr

Other

Re-posted 17 days ago


Job description

Summary:

Vaxcyte's Research team uses a broad palette of chromatographic tools to purify diverse vaccine antigens. Applicants must have practical, hands-on experience with multiple chromatographic modalities (not limited to monoclonal antibody/Protein A workflows). Experience should include selection, screening, development, scale-up and characterization of various chromatography techniques.

Essential Functions:
  • Execute the following AKTA FPLC chromatography techniques:
    • Immobilized metal affinity chromatography (IMAC)
    • Ion-exchange chromatography (IEX)
    • Hydrophobic interaction chromatography (HIC)
    • Size-exclusion chromatography (SEC)
    • Hydroxyapatite (CHT / HA)
  • Designing chromatography trains to reduce host cell protein, endotoxin and aggregates using complementary modalities.
  • Demonstrated DoE experience for multimodal optimization is a plus.
  • Membrane chromatography for high-throughput contaminant removal or virus/VLP processing and as a scale-friendly polishing/scavenging step.
  • Keep accurate and current records of development experiments and/or project related activities in an electronic laboratory notebook.
  • Present data from experiments to the team and contribute to technical discussions.
  • Work within a team environment and provides support as necessary to further the team's initiatives.
Requirements: 
  • BS in Biochemistry, Molecular Biology or a relevant science considered, with minimum of 6 years of relevant internship or industry experience. 
  • Experience with diverse protein targets, bacterial and eukaryotic recombinant proteins, small/large subunit vaccine antigens, fusion proteins, multimeric complexes, glycoproteins, and VLPs.
  • Familiarity capture/polishing methods and orthogonal cleaning strategies appropriate for potential vaccine antigens.
  • Familiarity with automation or high throughput workflows such as (96-well plates) and UNICORN/AKTA software DoE integrations.
  • Strong interpersonal skills to collaborate well within the team and excellent written and verbal communication skills.
Reports to: Senior Scientist, Research
 
Location: San Carlos, CA
 
Work Arrangement: Onsite 
 
Expected Contract Length: 12months
 
Hourly Range: $40/hr. - $45/hr. 

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About Vaxcyte

Sourced by ZipRecruiter

Industry

Biotechnology research and development

Company size

51 - 200 Employees

Headquarters location

San Carlos, CA, US

Year founded

2013