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Computer System Validation Manager Jobs in O Fallon, MO

Agile Defense

System Engineer (MBSE)

Saint Louis, MO · On-site

Leads requirements management, risk and issue management, technology readiness assessments, and ... Develop verification and validation methods, processes, logic, and plans in support of program ...

Agile Defense

System Engineer (MBSE)

Saint Louis, MO · Hybrid

Leads requirements management, risk and issue management, technology readiness assessments, and ... Develop verification and validation methods, processes, logic, and plans in support of program ...

Daikin

Controls Monitoring Tech 3

Chesterfield, MO

$29.75 - $39/hr

... diagnostics, system behavior analysis, and sequence validation across monitoring and service ... People Management: No Physical Requirements / Work Environment • Must be able to perform ...

Daikin

Controls Monitoring Tech 3

Chesterfield, MO

$29.75 - $39/hr

... diagnostics, system behavior analysis, and sequence validation across monitoring and service ... People Management: No Physical Requirements / Work Environment • Must be able to perform ...

Astrix Inc

Lab Metrologist

Saint Louis, MO · On-site

$30 - $40/hr

Experience working with computerized laboratory systems and validation activities * Strong understanding of preventative maintenance and instrument lifecycle management INDBH

BJC HealthCare

Accounts Payable Clerk

Fenton, MO · On-site

$18.50 - $23.25/hr

... and management. Preferred Qualifications Role Purpose Accurately enter data for all entities processing on the common BJC Accounts Payable computer system. Use basic data entry skills of accuracy ...

Clayco

Senior Controls Engineer

Saint Louis, MO · On-site

$90K - $119K/yr

Integrate Building Management Systems (BMS), Electrical Power Monitoring Systems (EPMS), and ... Conduct system testing, validation, and troubleshooting during commissioning and operational phases.

Clayco (LJC)

Senior Controls Engineer

Saint Louis, MO

$90K - $119K/yr

Integrate Building Management Systems (BMS), Electrical Power Monitoring Systems (EPMS), and ... Conduct system testing, validation, and troubleshooting during commissioning and operational phases.

Clayco (LJC)

Senior Controls Engineer

Saint Louis, MO

$90K - $119K/yr

Integrate Building Management Systems (BMS), Electrical Power Monitoring Systems (EPMS), and ... Conduct system testing, validation, and troubleshooting during commissioning and operational phases.

Clayco (LJC)

Senior Controls Engineer

Saint Louis, MO

$90K - $119K/yr

Integrate Building Management Systems (BMS), Electrical Power Monitoring Systems (EPMS), and ... Conduct system testing, validation, and troubleshooting during commissioning and operational phases.

Clayco (LJC)

Senior Controls Engineer

Saint Louis, MO · On-site

$90K - $119K/yr

Integrate Building Management Systems (BMS), Electrical Power Monitoring Systems (EPMS), and ... Conduct system testing, validation, and troubleshooting during commissioning and operational phases.

Clayco (LJC)

Senior Controls Engineer

Saint Louis, MO

$90K - $119K/yr

Integrate Building Management Systems (BMS), Electrical Power Monitoring Systems (EPMS), and ... Conduct system testing, validation, and troubleshooting during commissioning and operational phases.

Daikin

Controls Monitoring Tech 3

Chesterfield, MO · On-site

$29.75 - $39/hr

... diagnostics, system behavior analysis, and sequence validation across monitoring and service ... People Management: No Physical Requirements / Work Environment • Must be able to perform ...

ACE Hardware

Assistant Store Manager

Winfield, MO · On-site

Processes information and merchandise through computer system and POS register system. Assists with ... Manages 3-4 associates in the store. * Provide direction, coordination, and evaluation of the store ...

Niemann Foods

Assistant Store Manager

Winfield, MO · On-site

Processes information and merchandise through computer system and POS register system. Assists with ... Manages 3-4 associates in the store. * Provide direction, coordination, and evaluation of the store ...

Niemann Foods

Assistant Store Manager

Winfield, MO · On-site

Processes information and merchandise through computer system and POS register system. Assists with ... Manages 3-4 associates in the store. * Provide direction, coordination, and evaluation of the store ...

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Showing results 1-20

All JobsComputer System Validation Manager JobsComputer System Validation Manager Jobs in O'Fallon, MO

Computer System Validation Manager information

See O Fallon, MO salary details

$44.4K

$98.6K

$150.1K

How much do computer system validation manager jobs pay per year?

As of Jun 16, 2026, the average yearly pay for computer system validation manager in O'Fallon, MO is $98,614.00, according to ZipRecruiter salary data. Most workers in this role earn between $69,700.00 and $123,500.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Computer System Validation Manager, and why are they important?

To thrive as a Computer System Validation Manager, you need expertise in computer system validation regulations (such as GxP, FDA 21 CFR Part 11), strong project management skills, and a background in life sciences or IT. Familiarity with validation lifecycle documentation tools, quality management systems (QMS), and compliance software is often required, along with relevant certifications like PMP or CSV-related credentials. Exceptional attention to detail, analytical thinking, and effective communication are crucial soft skills for coordinating cross-functional teams and ensuring regulatory compliance. These skills and qualifications are vital to ensure validated systems meet regulatory standards, minimize compliance risks, and support organizational quality objectives.

What are some common challenges a Computer System Validation Manager faces during system implementation projects?

A Computer System Validation Manager often encounters challenges such as aligning validation activities with evolving regulatory requirements, managing tight project timelines, and coordinating between multiple stakeholders like IT, Quality Assurance, and business users. Ensuring thorough documentation and traceability, while adapting to technology updates or scope changes, can also be demanding. Proactive communication and strong project management skills are essential to mitigate risks and ensure successful, compliant system implementations.

What does a Computer System Validation Manager do?

A Computer System Validation Manager is responsible for ensuring that computer systems used in regulated industries, such as pharmaceuticals or biotechnology, meet all required compliance standards. They oversee the planning, execution, and documentation of validation activities to ensure systems are reliable, accurate, and secure. Their duties include managing validation projects, writing protocols, coordinating with IT and quality assurance teams, and ensuring adherence to regulations like FDA 21 CFR Part 11. This role is critical for maintaining product quality and regulatory compliance.

What is the difference between Computer System Validation Manager vs Computer System Validation Specialist?

AspectComputer System Validation ManagerComputer System Validation Specialist
CertificationsGAMP, CQE, CSQEGAMP, CQE, CSQE
Work EnvironmentManagement, oversight, strategic planningExecution, testing, documentation
Industry UsagePharmaceutical, biotech, regulated industriesPharmaceutical, biotech, regulated industries
Primary FocusLeading validation projects, team coordinationPerforming validation activities, testing

The main difference between a Computer System Validation Manager and a Computer System Validation Specialist lies in their roles. The manager oversees validation projects, manages teams, and ensures compliance, while the specialist executes validation tasks and documents testing procedures. Both roles require similar certifications and are vital in regulated industries like pharmaceuticals and biotech.

What job categories do people searching Computer System Validation Manager jobs in O'Fallon, MO look for? The top searched job categories for Computer System Validation Manager jobs in O'Fallon, MO are:
What cities near O'Fallon, MO are hiring for Computer System Validation Manager jobs? Cities near O'Fallon, MO with the most Computer System Validation Manager job openings:
Computer System Validation Manager jobs near you
Infographic showing various Computer System Validation Manager job openings in O'Fallon, MO as of June 2026, with employment types broken down into 2% Locum Tenens, 5% As Needed, 69% Full Time, 8% Part Time, 13% Contract, and 3% Nights. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $98,614 per year, or $47.4 per hour.
Information System Security Manager

Information System Security Manager

CALIBRE Systems

Saint Louis, MO • On-site

Full-time

Posted 23 days ago

Job description

Job Description
CALIBRE is an employee-owned mission focused solutions and digital transformation company. We are seeking an individual to be responsible for the cybersecurity of a program, organization, system, or enclave. Responsibilities and abilities for this position shall include, but not limited to:
  • Acquire and manage the necessary resources, including leadership support, financial resources, and key security personnel, to support information technology (IT) security goals and objectives and reduce overall organizational risk.
  • Acquire necessary resources, including financial resources, to conduct an effective enterprise continuity of operations program.
  • Advise senior management (e.g., Chief Information Officer [CIO]) on risk levels and security posture.
  • Advise senior management (e.g., CIO) on cost/benefit analysis of information security programs, policies, processes, systems, and elements.
  • Advise appropriate senior leadership or Authorizing Official of changes affecting the organization's cybersecurity posture.
  • Collect and maintain data needed to meet system cybersecurity reporting
  • Communicate the value of information technology (IT) security throughout all levels of the organization stakeholders.
  • Collaborate with stakeholders to establish the enterprise continuity of operations program, strategy, and mission assurance.
  • Ensure that security improvement actions are evaluated, validated, and implemented as required.
  • Ensure that cybersecurity inspections, tests, and reviews are coordinated for the network environment.
  • Ensure that cybersecurity requirements are integrated into the continuity planning for that system and/or organization(s).
  • Ensure that protection and detection capabilities are acquired or developed using the IS security engineering approach and are consistent with organization-level cybersecurity architecture.
  • Establish overall enterprise information security architecture (EISA) with the organization's overall security strategy.
  • Evaluate and approve development efforts to ensure that baseline security safeguards are appropriately installed.
  • Evaluate cost/benefit, economic, and risk analysis in decision-making process.
  • Identify alternative information security strategies to address organizational security objectives.
  • Identify information technology (IT) security program implications of new technologies or technology upgrades.
  • Interface with external organizations (e.g., public affairs, law enforcement, Command or Component Inspector General) to ensure appropriate and accurate dissemination of incident and other Computer Network Defense information.
  • Interpret and/or approve security requirements relative to the capabilities of new information technologies.
  • Interpret patterns of noncompliance to determine their impact on levels of risk and/or overall effectiveness of the enterprise's cybersecurity program.
  • Lead and align information technology (IT) security priorities with the security strategy.
  • Lead and oversee information security budget, staffing, and contracting.
  • Manage the monitoring of information security data sources to maintain organizational situational awareness.
  • Manage the publishing of Computer Network Defense guidance (e.g., TCNOs, Concept of Operations, Net Analyst Reports, NTSM, MTOs) for the enterprise constituency.
  • Manage threat or target analysis of cyber defense information and production of threat information within the enterprise.
  • Monitor and evaluate the effectiveness of the enterprise's cybersecurity safeguards to ensure that they provide the intended level of protection.
  • Oversee the information security training and awareness program.
  • Participate in an information security risk assessment during the Security Assessment and Authorization process.
  • Prepare, distribute, and maintain plans, instructions, guidance, and standard operating procedures concerning the security of network system(s) operations.
  • Provide enterprise cybersecurity and supply chain risk management guidance for development of the Continuity of Operations Plans.
  • Provide leadership and direction to information technology (IT) personnel by ensuring that cybersecurity awareness, basics, literacy, and training are provided to operations personnel commensurate with their responsibilities.
  • Ability to apply techniques for detecting host and network-based intrusions using intrusion detection technologies.
  • Ability to integrate information security requirements into the acquisition process; using applicable baseline security controls as one of the sources for security requirements; ensuring a robust software quality control process; and establishing multiple sources (e.g., delivery routes, for critical system elements).
  • Ability to identify critical infrastructure systems with information communication technology that were designed without system security considerations.

Required Skills
  • Associate's degree or higher from an accredited college or university (Prefer an accredited Computer Science, Cyber Security, Information Technology, Software Engineering, Information Systems, or Computer Engineering degree, or a degree in a Mathematics or Engineering field.)

Required Experience
Requirements for this position shall include:
  • CISSP-ISSMP or GSLC - IAT, IAM, or IASAE Level 3 Certification
  • ACTIVE TS/SCI Clearance is required

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