ZipRecruiter

Log In

1

Computer System Validation Manager Jobs in O Fallon, MO

Agile Defense

System Engineer (MBSE)

Saint Louis, MO · On-site

Leads requirements management, risk and issue management, technology readiness assessments, and ... Test and validate to ensure system designs meet operational and functional requirements. Education ...

Agile Defense

System Engineer (MBSE)

Saint Louis, MO · Hybrid

Leads requirements management, risk and issue management, technology readiness assessments, and ... Test and validate to ensure system designs meet operational and functional requirements. Education ...

BJC HealthCare

Accounts Payable Clerk

Fenton, MO · On-site

$18.50 - $23.25/hr

... and management. Preferred Qualifications Role Purpose Accurately enter data for all entities processing on the common BJC Accounts Payable computer system. Use basic data entry skills of accuracy ...

Clayco

Senior Controls Engineer

Saint Louis, MO · On-site

$90K - $119K/yr

Integrate Building Management Systems (BMS), Electrical Power Monitoring Systems (EPMS), and ... Conduct system testing, validation, and troubleshooting during commissioning and operational phases.

Clayco (LJC)

Senior Controls Engineer

Saint Louis, MO · On-site

$90K - $119K/yr

Integrate Building Management Systems (BMS), Electrical Power Monitoring Systems (EPMS), and ... Conduct system testing, validation, and troubleshooting during commissioning and operational phases.

Doe Run

HRIS Analyst

Saint Louis, MO

Bachelor's Degree in HR, Computer Science, or related field and 3 years of relevant experience in H ... Proficient organizational and time management skills. * Proficient project management skills ...

Clayco (LJC)

Senior Controls Engineer

Saint Louis, MO

$90K - $119K/yr

Integrate Building Management Systems (BMS), Electrical Power Monitoring Systems (EPMS), and ... Conduct system testing, validation, and troubleshooting during commissioning and operational phases.

Clayco (LJC)

Senior Controls Engineer

Saint Louis, MO

$90K - $119K/yr

Integrate Building Management Systems (BMS), Electrical Power Monitoring Systems (EPMS), and ... Conduct system testing, validation, and troubleshooting during commissioning and operational phases.

Clayco (LJC)

Senior Controls Engineer

Saint Louis, MO · On-site

$90K - $119K/yr

Integrate Building Management Systems (BMS), Electrical Power Monitoring Systems (EPMS), and ... Conduct system testing, validation, and troubleshooting during commissioning and operational phases.

Clayco (LJC)

Senior Controls Engineer

Saint Louis, MO

$90K - $119K/yr

Integrate Building Management Systems (BMS), Electrical Power Monitoring Systems (EPMS), and ... Conduct system testing, validation, and troubleshooting during commissioning and operational phases.

General Grant Car Wash

Car Wash Loader

Webster Groves, MO · On-site

$12.50 - $15/hr

... basic computer system to send cars through the car wash tunnel. -Operating the car wash conveyor ... Requirements: -Must have valid driver license and clean driving record. -Must be able to drive a ...

the Doe Run company

HRIS Analyst

Saint Louis, MO · On-site

Bachelor's Degree in HR, Computer Science, or related field and 3 years of relevant experience in H ... Proficient organizational and time management skills. * Proficient project management skills ...

804 Technology

CAD Drafter

Saint Louis, MO

$25 - $30/hr

Current system is CabinetVision. Requirements * At least 1 solid year of experience in a ... managers. * Desire team players that will work overtime when needed.

Actalent

CAD Designer

Saint Charles, MO

$25.50 - $35/hr

Electrical CAD Designer The Electrical CAD Designer supports manufacturing plant operations by ... Experience using document and revision control systems to manage engineering drawings and records.

New

Actalent

Cad Designer

Saint Charles, MO

$25.50 - $35/hr

Electrical CAD Designer The Electrical CAD Designer supports manufacturing plant operations by ... Experience using document and revision control systems to manage engineering drawings and records.

New

previous page

Showing results 41-60

All JobsComputer System Validation JobsComputer System Validation Manager JobsComputer System Validation Manager Jobs in O'Fallon, MO

Computer System Validation Manager information

See O Fallon, MO salary details

$44.4K

$98.6K

$150.1K

How much do computer system validation manager jobs pay per year?

As of Aug 12, 2026, the average yearly pay for computer system validation manager in O'Fallon, MO is $98,614.00, according to ZipRecruiter salary data. Most workers in this role earn between $69,700.00 and $123,500.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a computer system validation manager, and why are they important?

To thrive as a Computer System Validation Manager, you need expertise in computer system validation regulations (such as GxP, FDA 21 CFR Part 11), strong project management skills, and a background in life sciences or IT. Familiarity with validation lifecycle documentation tools, quality management systems (QMS), and compliance software is often required, along with relevant certifications like PMP or CSV-related credentials. Exceptional attention to detail, analytical thinking, and effective communication are crucial soft skills for coordinating cross-functional teams and ensuring regulatory compliance. These skills and qualifications are vital to ensure validated systems meet regulatory standards, minimize compliance risks, and support organizational quality objectives.

What are some common challenges a computer system validation manager faces during system implementation projects?

A Computer System Validation Manager often encounters challenges such as aligning validation activities with evolving regulatory requirements, managing tight project timelines, and coordinating between multiple stakeholders like IT, Quality Assurance, and business users. Ensuring thorough documentation and traceability, while adapting to technology updates or scope changes, can also be demanding. Proactive communication and strong project management skills are essential to mitigate risks and ensure successful, compliant system implementations.

What does a computer system validation manager do?

A Computer System Validation Manager is responsible for ensuring that computer systems used in regulated industries, such as pharmaceuticals or biotechnology, meet all required compliance standards. They oversee the planning, execution, and documentation of validation activities to ensure systems are reliable, accurate, and secure. Their duties include managing validation projects, writing protocols, coordinating with IT and quality assurance teams, and ensuring adherence to regulations like FDA 21 CFR Part 11. This role is critical for maintaining product quality and regulatory compliance.

What is the difference between Computer System Validation Manager vs Computer System Validation Specialist?

AspectComputer System Validation ManagerComputer System Validation Specialist
CertificationsGAMP, CQE, CSQEGAMP, CQE, CSQE
Work EnvironmentManagement, oversight, strategic planningExecution, testing, documentation
Industry UsagePharmaceutical, biotech, regulated industriesPharmaceutical, biotech, regulated industries
Primary FocusLeading validation projects, team coordinationPerforming validation activities, testing

The main difference between a Computer System Validation Manager and a Computer System Validation Specialist lies in their roles. The manager oversees validation projects, manages teams, and ensures compliance, while the specialist executes validation tasks and documents testing procedures. Both roles require similar certifications and are vital in regulated industries like pharmaceuticals and biotech.

What cities near O'Fallon, MO are hiring for Computer System Validation Manager jobs? Cities near O'Fallon, MO with the most Computer System Validation Manager job openings:
Computer System Validation Manager jobs near you
Infographic showing various Computer System Validation Manager job openings in O'Fallon, MO as of July 2026, with employment types broken down into 57% Full Time, and 43% Contract. Highlights an 100% In-person job distribution, with an average salary of $98,614 per year, or $47.4 per hour.

System Engineer (MBSE)

Agile Defense

Saint Louis, MO • On-site

Other

Re-posted 8 days ago

Job description

About Agile Defense
At Agile Defense we know that action defines the outcome and new challenges require new solutions. That's why we always look to the future and embrace change with an unmovable spirit and the courage to build for what comes next.
Our vision is to bring adaptive innovation to support our nation's most important missions through the seamless integration of advanced technologies, elite minds, and unparalleled agility-leveraging a foundation of speed, flexibility, and ingenuity to strengthen and protect our nation's vital interests.
Requisition #: 1647
Job Title: System Engineer (MBSE)
Location: Hybrid, St Louis, MO
Clearance Level: Secret, Must Have Clearance to Start
Job Description
This position Applies a collaborative, interdisciplinary systems engineering approach to plan, design, develop, integrate, and verify complex systems and system-of-systems solutions throughout the lifecycle. Analyzes customer and operational requirements to define system performance, ensure compatibility across technical and program interfaces, and optimize overall system architecture. Conducts engineering analyses to support affordability, reliability, maintainability, safety, cybersecurity, certification, and mission assurance objectives. Leads requirements management, risk and issue management, technology readiness assessments, and systems engineering processes while resolving cross-functional technical challenges to ensure successful mission outcomes.
  • Perform analysis to optimize total system and/or system architecture to solve complex mission planning problems.
  • Apply interdisciplinary, collaborative approaches to plan, design, develop and verify system solutions.
  • Define and coordinate system performance requirements and integrate technical parameters.
  • Define high level functional and performance requirements and verification methods, subsequent analysis, decomposition, and derivation of requirements, allocation of those lower-level requirements to physical and functional architectural elements, and tracking them through design, verification, integration, and operational validation.
  • Perform analyses for affordability, safety, reliability, maintainability, testability, survivability, human systems integration, survivability, vulnerability, susceptibility, system security, regulatory, certification, product assurance, product security (cyber security) and other specialties quality factors into a preferred configuration to ensure mission success.
  • Utilization of Model-Based Systems Engineering (MBSE) tools such as Cameo, and mathematical modeling and simulation to develop system definitions and perform trade studies in assigned areas
  • Perform risk assessments and generate mitigation plans for various programs with regard to compliance with system requirements and customer capabilities
  • Develop verification and validation methods, processes, logic, and plans in support of program milestones.
  • Develop and document software system requirements
  • Analyze and translate requirements into system architecture, hardware and software designs and interface specifications
  • Test and validate to ensure system designs meet operational and functional requirements.

Education and Background
  • Bachelor, Master or Doctorate of Science degree from an accredited course of study, in Computer Engineering, Software Engineering, Computer Science, Mathematics, or other technical degreeExperience with software configuration management tools such as Team Foundation Server/Azure DevOps
  • Experience writing and analyzing test procedures and software requirements
  • Experience with OFP (Operational Flight Program) SIL (System Integration Lab) testing

Years of Experience
5+ years
Required Skills
5+ years of experience in system engineering, 1+ years of experience with Scaled Agile Framework or Agile Methodologies
Working Conditons
Typical office environment.
Our Core Values
Employees of Agile Defense are our number one priority, and the importance we place on our culture here is fundamental. Our culture is alive and evolving, but it always stays true to its roots. Here, you are valued as a family member, and we believe that we can accomplish great things together. Agile Defense has been highly successful in the past few years due to our employees and the culture we create together.
What makes us Agile? We call it the 6Hs, the values that define our culture and guide everything we do. Together, these values infuse vibrancy, integrity, and a tireless work ethic into advancing the most important national security and critical civilian missions. It's how we show up every day. It's who we are.
  • Happy - Be Infectious. Happiness multiplies and creates a positive and connected environment where motivation and satisfaction have an outsized effect on everything we do.
  • Helpful - Be Supportive. Being helpful is the foundation of teamwork, resulting in a supportive atmosphere where collaboration flourishes, and collective success is celebrated.
  • Honest - Be Trustworthy. Honesty serves as our compass, ensuring transparent communication and ethical conduct, essential to who we are and the complex domains we support.
  • Humble - Be Grounded. Success is not achieved alone, humility ensures a culture of mutual respect, encouraging open communication, and a willingness to learn from one another and take on any task.
  • Hungry - Be Eager. Our hunger for excellence drives an insatiable appetite for innovation and continuous improvement, propelling us forward in the face of new and unprecedented challenges.
  • Hustle - Be Driven. Hustle is reflected in our relentless work ethic, where we are each committed to going above and beyond to advance the mission and achieve success.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

Apply