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Computer System Programmer Jobs in Saint Louis, MO

Nextaff

Programmer

Cottleville, MO · On-site

$62K - $122K/yr

Writing code and implementing computer programs on multiple systems in the business. Building and using computer-assisted software engineering tools to automate some coding. Performing all ...

CDIT LLC

Lead System Engineer

Scott Air Force Base, IL · On-site

Lead Systems Engineer The Lead Systems Engineer shall have a master's degree in Management Information Systems,Computer Science/Engineering, systems engineering or related field and a minimum of ten ...

Agile Defense

System Engineer (MBSE)

Saint Louis, MO · On-site

System Engineer (MBSE) Location: Hybrid, St Louis, MO Clearance Level: Secret, Must Have Clearance ... Bachelor, Master or Doctorate of Science degree from an accredited course of study, in Computer ...

Agile Defense

System Engineer (MBSE)

Saint Louis, MO · Hybrid

System Engineer (MBSE) Location: Hybrid, St Louis, MO Clearance Level: Secret, Must Have Clearance ... Bachelor, Master or Doctorate of Science degree from an accredited course of study, in Computer ...

teKnoluxion

Linux Systems Engineer

Saint Louis, MO

Bash & Python) * Standardize system configuration, patching, and deployment processes through ... Requires Bachelor's degree in computer science engineering, or a related technical discipline, or ...

IC-CAP LLC

System Engineer (Senior) 112-131

Saint Louis, MO · On-site

$101K - $139K/yr

Masters degree in System Engineering or in a related technical or scientific field such as engineering, physics, mathematics, operations research, engineering management, Computer Science ...

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Computer System Programmer information

See Saint Louis, MO salary details

$16

$46

$76

How much do computer system programmer jobs pay per hour?

As of Jul 30, 2026, the average hourly pay for computer system programmer in Saint Louis, MO is $46.57, according to ZipRecruiter salary data. Most workers in this role earn between $33.75 and $58.27 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Computer System Programmer, and why are they important?

To thrive as a Computer System Programmer, you need strong programming abilities in languages such as C, C++, or Java, along with a degree in computer science or a related field. Familiarity with operating systems, integrated development environments (IDEs), and version control systems like Git is typically required. Attention to detail, analytical thinking, and effective problem-solving are essential soft skills that distinguish top performers. These competencies ensure the development of reliable, efficient, and maintainable systems that meet organizational and user needs.

What is the difference between Computer System Programmer vs Software Developer?

AspectComputer System ProgrammerSoftware Developer
CredentialsTypically requires a degree in computer science or related field; certifications like CompTIA or Microsoft may be beneficialSimilar educational background; often holds degrees in computer science, software engineering, or related fields
Work EnvironmentWorks mainly in IT departments, focusing on system-level programming, operating systems, and hardware integrationWorks in various industries, developing applications, web, mobile, or enterprise software
Industry UsageCommonly employed in technology firms, government agencies, and organizations with complex IT infrastructureWidely used across tech companies, startups, and businesses developing consumer or enterprise software

While both roles require programming skills and a similar educational background, Computer System Programmers focus on system-level software and hardware integration, whereas Software Developers create applications and user-facing software solutions.

What are computer system programmers?

Computer system programmers are professionals who write, test, and maintain the software that enables computers and networks to function effectively. They typically work on system-level software such as operating systems, network distribution software, and compilers, ensuring that computer hardware and software work seamlessly together. Their role often involves debugging, updating, and optimizing existing code to improve system performance and security. Computer system programmers may also collaborate with hardware engineers and other IT professionals to integrate new technologies into existing systems.

What are the typical collaboration dynamics between computer system programmers and other IT professionals?

Computer system programmers frequently collaborate with system analysts, network engineers, and software developers to ensure that new or modified systems integrate seamlessly with existing infrastructure. They often participate in meetings to discuss technical requirements, troubleshoot issues alongside IT support teams, and work closely with quality assurance professionals to test system functionality. Strong communication and teamwork skills are essential, as these collaborations are crucial for identifying potential problems early and ensuring project success.
What are popular job titles related to Computer System Programmer jobs in Saint Louis, MO? For Computer System Programmer jobs in Saint Louis, MO, the most frequently searched job titles are:
What job categories do people searching Computer System Programmer jobs in Saint Louis, MO look for? The top searched job categories for Computer System Programmer jobs in Saint Louis, MO are:
Computer System Programmer jobs near you

Computer Systems Validation Specialist

kindeva

Saint Louis, MO

Other

Re-posted 15 days ago

Kindeva rating

6.7

Company rating: 6.7 out of 10

Based on 9 frontline employees who took The Breakroom Quiz

Job description

Our Work Matters

At Kindeva we make products that save lives, ensuring better health and well-being for patients around the world.

The Impact You Will Make

The Computer System Validation (CSV) Specialist is responsible for ensuring that all GxP computer systems used in pharmaceutical manufacturing environments are validated, maintained, and compliant with applicable regulatory requirements including FDA 21 CFR Part 11, EU Annex 11, and GAMP 5 guidelines.

This role supports the full lifecycle of computerized systems including implementation, qualification, maintenance, periodic review, and retirement, ensuring data integrity, system reliability, and inspection readiness across multiple sites or facilities.

Responsibilities

  • Validation Lifecycle Execution
    • Lead and/or support validation activities for GxP computerized systems including MES, SCADA/PLC, LIMS, EM systems, and serialization/packaging systems
    • Author and execute validation documentation: URS, FS/DS, Risk Assessments, IQ/OQ/PQ, Traceability Matrices, Periodic Reviews / Audit Trail Reviews
    • Ensure validation deliverables meet internal SOPs and regulatory expectation
  • Regulatory Compliance & Data Integrity
    • Ensure compliance with 21 CFR Part 11, EU Annex 11, and ALCOA+ principles
    • Perform periodic reviews of validated systems
    • Support FDA, EMA, and internal audits/inspections
    • Assess and remediate data integrity risks
  • Change Control & Lifecycle Management
    • Support system changes through formal change control processes
    • Evaluate impact of updates, patches, and configuration changes
    • Ensure appropriate re-validation activities
    • Maintain systems in a validated state
  • Risk-Based Validation Strategy
    • Apply GAMP 5 risk-based validation approach
    • Classify systems based on complexity and GxP impact
    • Lead risk assessments (FMEA, system risk ranking)
  • Cross-Functional Collaboration
    • Partner with IT, QA, Manufacturing, MS&T, and Engineering
    • Provide CSV guidance during system implementation and facility startup
    • Support digital transformation initiatives
  • Documentation & Inspection Readiness
    • Maintain GMP-compliant validation documentation
    • Ensure audit readiness and traceability
    • Support responses to audit findings and regulatory observations
  • Continuous Improvement
    • Improve validation processes and templates
    • Support implementation of electronic validation systems (e.g., Kneat, Veeva)
    • Drive standardization across sites

Qualifications

  • Bachelor’s degree in Engineering, Computer Science, Information Systems, Life Sciences, or related field
  • Minimum of 5 years in Computer System Validation in GMP-regulated pharmaceutical or biotech environments
  • Experience with manufacturing and laboratory systems validation
  • Hands-on experience with Part 11 / Annex 11 compliance
  • Strong knowledge of GAMP 5, 21 CFR Part 11, EU Annex 11, and ALCOA+
  • Familiarity with MES, ERP, LIMS, SCADA/PLC systems
  • Understanding of system architecture, interfaces, backup, disaster recovery, and cybersecurity
  • Experience in aseptic/sterile injectable manufacturing preferred
  • Multi-site validation program experience preferred
  • Familiarity with serialization, AVI systems, and cold storage monitoring preferred
  • Experience with Kneat, ValGenesis, or Veeva is desirable
  • Experience with facility startup and commissioning

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