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Computer Science Bioinformatics Jobs in California

Arc Institute

Scientist, Bioinformatics

Palo Alto, CA · On-site

D. in Bioinformatics, Computational Biology, Computer Science, or related quantitative field. • 1-2 years of post-Ph.D. experience in bioinformatics, computational biology, genomics, or related ...

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Computer Science Bioinformatics information

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$5

$43

How much do computer science bioinformatics jobs pay per hour?

As of Jul 19, 2026, the average hourly pay for computer science bioinformatics in California is $42.23, according to ZipRecruiter salary data. Most workers in this role earn between $41.97 and $42.45 per hour, depending on experience, location, and employer.

Is AI going to replace bioinformatics?

AI is a tool that enhances bioinformatics by automating data analysis and pattern recognition, but it is not expected to fully replace bioinformatics professionals. Bioinformatics jobs require expertise in biology, programming, and data interpretation, which AI cannot fully replicate. Instead, AI serves as a complementary skill for bioinformaticians to improve efficiency and discovery.

How is computer science used in bioinformatics?

In bioinformatics, computer science is used to develop algorithms, software, and databases for analyzing biological data such as DNA, RNA, and protein sequences. Bioinformatics professionals often utilize programming languages like Python or R, and tools like machine learning and data mining to interpret complex biological information efficiently.

What are some typical daily responsibilities for someone working in Computer Science Bioinformatics?

Professionals in Computer Science Bioinformatics typically spend their days designing and implementing algorithms to analyze large-scale biological datasets, developing custom software tools, and interpreting results to support ongoing research. Collaboration with biologists, clinicians, and other computational scientists is common, requiring regular meetings to discuss project goals, troubleshoot issues, and refine data analysis approaches. You may also be expected to keep up with new technologies and scientific literature to ensure your methods remain cutting-edge. The dynamic nature of this field means your tasks can evolve quickly, providing opportunities to tackle novel problems and drive meaningful impact in science and medicine.

What are the key skills and qualifications needed to thrive in the Computer Science Bioinformatics position, and why are they important?

To thrive in Computer Science Bioinformatics, you need a solid background in computer science, biology, and statistics, often supported by a relevant degree or advanced certification. Proficiency in programming languages such as Python, R, and experience with bioinformatics tools and databases like BLAST, GenBank, and cloud platforms are highly valuable. Strong analytical thinking, problem-solving abilities, and effective communication are essential soft skills for this interdisciplinary field. These skills allow professionals to efficiently analyze complex biological data, collaborate with cross-functional teams, and contribute to critical discoveries in healthcare and biotechnology.

What biology jobs pay over $100k?

In bioinformatics and related biology fields, roles such as senior bioinformatics scientist, computational biologist, and data scientist often have salaries exceeding $100,000 annually. These positions typically require advanced skills in programming, data analysis, and knowledge of biological data, often with a master's or Ph.D. degree. Experience, industry sector, and geographic location can influence salary levels.

What is a Computer Science Bioinformatics job?

A Computer Science Bioinformatics job involves using computational techniques to analyze and interpret biological data, such as DNA sequences, protein structures, and genomic information. Professionals in this field develop algorithms, software tools, and databases to support biological research and medical advancements. They work in areas like genomics, drug discovery, and personalized medicine, often collaborating with biologists, chemists, and healthcare professionals. Strong programming skills, data analysis expertise, and knowledge of biology are essential for success in this field.

What jobs can I get with bioinformatics?

With a background in bioinformatics, common jobs include bioinformatics analyst, computational biologist, research scientist, and data analyst in healthcare, pharmaceuticals, or biotech companies. These roles often require skills in programming, data analysis, and knowledge of biological data, and may involve working with tools like R, Python, or specialized bioinformatics software.
What are the most commonly searched types of Computer Science Bioinformatics jobs in California? The most popular types of Computer Science Bioinformatics jobs in California are:
What are popular job titles related to Computer Science Bioinformatics jobs in California? For Computer Science Bioinformatics jobs in California, the most frequently searched job titles are:
What job categories do people searching Computer Science Bioinformatics jobs in California look for? The top searched job categories for Computer Science Bioinformatics jobs in California are:
What cities in California are hiring for Computer Science Bioinformatics jobs? Cities in California with the most Computer Science Bioinformatics job openings:
Computer Science Bioinformatics jobs near you
Staff Bioinformatics Scientist

Staff Bioinformatics Scientist

Exact Sciences

La Jolla, CA • On-site

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 6 days ago

Exact Sciences rating

8.5

Company rating: 8.5 out of 10

Based on 54 frontline employees who took The Breakroom Quiz

21st of 105 rated laboratories

Job description

Help us change lives
At Exact Sciences, we're helping change how the world prevents, detects and guides treatment for cancer. We give patients and clinicians the clarity needed to make confident decisions when they matter most. Join our team to find a purpose-driven career, an inclusive culture, and robust benefits to support your life while you're working to help others.
Position Overview
Staff Bioinformatics Scientist will lead the development and application of machine learning, statistical modeling, and bioinformatics for next-generation sequencing-based products. This individual will serve as a senior technical leader within Research and Development, working cross-functionally with bioinformatics, assay development, data engineering, software development, quality and product development teams.
The ideal candidate has deep experience analyzing large and complex biological datasets in an industry setting and has demonstrated successful development, validation and deployment of algorithms, statistical and machine learning models using principled and reproducible methodology.
This is a senior individual contributor role requiring strong scientific and technical leadership, and the ability to translate complex genomic data into insights and products.
Essential Duties
Include, but are not limited to, the following:
  • Lead the development, evaluation and optimization of machine learning and statistical models for high-dimensional NGS and genomics datasets.
  • Design and implement bioinformatics algorithms to support NGS assay development, analytical performance evaluation, quality control, signal detection, classification, or interpretation.
  • Collaborate with wet-lab scientists to design experiments, interpret results, identify technical issues, and recommend next steps.
  • Apply rigorous statistical and computational methods to evaluate assay performance, reproducibility, robustness, sensitivity, specificity, and sources of technical or biological variation.
  • Develop reproducible analysis workflows using modern bioinformatics, data science, and software engineering practices.
  • Work within cloud computing environments to process, analyze, and manage large-scale sequencing datasets.
  • Present and summarize complex technical findings effectively to cross-functional audiences.
  • Serve as subject matter expert for NGS bioinformatics, machine learning and statistical analysis.
  • Identify opportunities and build out proof of concept implementations for new state-of-the-art methodology across machine learning, bioinformatics and software engineering
  • Provide guidance and mentorship to junior team members.
  • Support development activities within a quality-managed or regulated environment.
  • Uphold company mission and values through accountability, innovation, integrity, quality, and teamwork.
  • Support and comply with the company's Quality Management System policies and procedures.
  • Maintain regular and reliable attendance.
  • Ability to act with an inclusion mindset and model these behaviors for the organization.
  • Ability to work on a mobile device, tablet, or in front of a computer screen and/or perform typing for approximately 90% of a typical working day.
  • Ability to work on a computer and phone simultaneously.
  • Ability to travel 10% of working time away from work location, may include overnight/weekend travel.

Minimum Qualifications
  • Ph.D. in bioinformatics, computational biology, computer science, mathematics, or related field; or Master's degree in bioinformatics, computational biology, computer science, mathematics, or related field plus 4 years of experience in lieu of a Ph.D.; or Bachelor's degree in bioinformatics, computational biology, computer science, mathematics, or related field plus 6 years of experience in lieu of Ph.D.
  • 8+ years of industry or academia experience in bioinformatics.
  • 6+ years of experience in medical device/IVD, biotech, life science or pharmaceutical industry.
  • Demonstrated experience in developing statistical and quantitative methods.
  • Deep knowledge and thorough understanding of molecular biology and/or biochemistry and/or next-generation sequencing (NGS) and genomics.
  • Demonstrated expertise in product/assay research, design, or development.
  • Basic computer skills to include Internet navigation, Email usage, and word processing. Proficient in Microsoft Office to include Excel, Word, and PowerPoint.
  • Demonstrated ability to perform the Essential Duties of the position with or without accommodation.

Preferred Qualifications
  • 10+ years of experience in medical device/IVD, biotech, life science or pharmaceutical industry.
  • Deep expertise in NGS bioinformatics and genomic data analysis.
  • Practical experience effectively leveraging AI in regulated environments
  • Experience with modern cloud-based MLOps systems
  • Experience developing and applying advanced linear and non-linear statistical learning methods on complex datasets, including but not limited to supervised and unsupervised machine learning techniques.
  • Familiarity with applying deep learning to high dimensional data.
  • Previous experience as a project lead for a team of scientists.
  • 2+ years of direct people leadership and management experience.
  • Experience in a pharmaceutical or biotech manufacturing environment, preferably in a GMP and/or ISO environment.
  • Previous industry experience in product development or technical support.
  • Previous experience working in molecular diagnostics.

#LI-CB1
Salary Range:
California Ranges: $154,400.00 - $231,600.00
The annual base salary shown is a national range for this position on a full-time basis and may differ by hiring location. In addition, this position is bonus eligible.
Exact Sciences is proud to offer an employee experience that includes paid time off (including days for vacation, holidays, volunteering, and personal time), paid leave for parents and caregivers, a retirement savings plan, wellness support, and health benefits including medical, prescription drug, dental, and vision coverage. Learn more about our benefits.
Our success relies on the experiences and perspectives of a diverse team, and Exact Sciences fosters a culture where all employees can develop personally and professionally with a sense of respect and belonging. If you require an accommodation, please contact us here.
Not ready to apply? Join our Talent Community to stay updated on the latest news and opportunities at Exact Sciences.
We are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to disability, protected veteran status, and any other status protected by applicable local, state, or federal law.
To view the Right to Work, E-Verify Employer, and Pay Transparency notices and Federal, Federal Contractor, and State employment law posters, visit our compliance hub. The documents summarize important details of the law and provide key points that you have a right to know.

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