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Computational Software Developer Jobs in Santa Clara, CA

Roblox

Senior Software Engineer, Geometry

San Mateo, CA · On-site

$139K - $183K/yr

As a Senior Software Engineer on our Geometry team, you will drive foundational algorithms for real ... Working in a small, autonomous team, you will solve novel math computational problems and deliver ...

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Computational Software Developer information

See Santa Clara, CA salary details

$56.4K

$131.4K

$195K

How much do computational software developer jobs pay per year?

As of Sep 7, 2026, the average yearly pay for computational software developer in Santa Clara, CA is $131,355.00, according to ZipRecruiter salary data. Most workers in this role earn between $105,700.00 and $152,700.00 per year, depending on experience, location, and employer.

What is a computational software developer?

A Computational Software Developer is a professional who designs, develops, and maintains software systems that perform complex mathematical, scientific, or engineering computations. They often work in fields such as scientific research, engineering, finance, and data analysis, creating tools that simulate processes, analyze data, or solve computational problems. These developers typically possess strong programming skills in languages like Python, C++, or MATLAB, and have a solid understanding of algorithms, mathematics, and domain-specific knowledge relevant to their projects.

What are the key skills and qualifications needed to thrive as a computational software developer, and why are they important?

To thrive as a Computational Software Developer, you need strong programming skills (often in languages like Python, C++, or Java), a solid understanding of algorithms, and typically a degree in computer science, mathematics, or a related field. Familiarity with computational libraries (such as NumPy, SciPy, or TensorFlow), version control systems like Git, and experience with high-performance or parallel computing are commonly required. Analytical thinking, problem-solving abilities, and effective teamwork are vital soft skills for excelling in this role. These skills and qualities enable developers to create robust, efficient computational solutions and collaborate effectively within multidisciplinary teams.

What are some common challenges faced by computational software developers, and how can they be addressed?

Computational Software Developers often encounter challenges such as optimizing code for high-performance computing, ensuring numerical accuracy, and integrating complex algorithms with existing systems. These challenges can be addressed by staying up-to-date with the latest computational techniques, collaborating closely with domain experts, and utilizing profiling tools to identify performance bottlenecks. Regular code reviews and testing are also essential to maintain reliability and foster knowledge sharing within multidisciplinary teams.

What are popular job titles related to Computational Software Developer jobs in Santa Clara, CA?

For Computational Software Developer jobs in Santa Clara, CA, the most frequently searched job titles are:

What job categories do people searching Computational Software Developer jobs in Santa Clara, CA look for?

The top searched job categories for Computational Software Developer jobs in Santa Clara, CA are:

What cities near Santa Clara, CA are hiring for Computational Software Developer jobs?

Cities near Santa Clara, CA with the most Computational Software Developer job openings:

Computational Software Developer jobs near you
Infographic showing various Computational Software Developer job openings in Santa Clara, CA as of August 2026, with employment types broken down into 88% Full Time, 8% Part Time, and 4% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $131,355 per year, or $63.2 per hour.

Staff / Principal Software Engineer

GenBio.ai, Inc.

Palo Alto, CA • On-site

$250/hr

Other

Posted 20 days ago

Job description

GenBio AI is building the Virtual Cell World Model - a persistent, multimodal AI system that predicts, simulates, and ultimately programs cellular behavior. Rather than producing isolated predictions, the Virtual Cell enables scientists to query cellular states, perform virtual perturbations, and design new biological interventions within a unified computational world. Together with AIDO Foundry, our AI-native engineering framework for automating Virtual Cell development, we are building the software infrastructure for the next generation of AI-driven drug discovery.

We are seeking an experienced Staff to Principal-level Software Engineer to build the user-facing platform that brings these capabilities to computational biologists, experimental scientists, and pharmaceutical researchers. This is a senior individual contributor role for engineers who enjoy solving challenging systems problems while working closely with AI researchers and product teams.

Responsibilities
  • Act as a senior technical leader to build the software platform for programmable biology, developing production-grade backend services and APIs for our Virtual Cell products.
  • Design clean, robust interfaces that seamlessly connect frontend applications, core business logic, massive biological databases, and state-of-the-art AI inference engines.
  • Architect and develop highly scalable systems for complex biological simulations, experiment management, workflow orchestration, and the processing of multimodal biological data.
  • Drive continuous improvements in platform performance and reliability through highly efficient architecture design, strategic caching, asynchronous execution, and optimized distributed infrastructure.
  • Collaborate closely with AI researchers to translate cutting-edge foundation models into reliable, user-facing scientific products that enable virtual perturbations and hypothesis generation.
  • Work cross-functionally across frontend, backend, infrastructure, and machine learning teams to deliver deeply intuitive computational experiences for biologists, experimental scientists, and pharmaceutical researchers.
Qualifications
  • Extensive industry experience (typically 8+ years) operating at a Staff or Principal level, with a proven track record of building production web services, scalable APIs, and complex distributed backend systems.
  • Exceptional software engineering fundamentals, demonstrating a mastery of clean architecture, modular system design, and the ability to write highly maintainable, performant code.
  • Deep, hands-on experience integrating large-scale AI, LLMs, or machine learning inference systems into highly available production environments.
  • Proven ability to solve challenging, ambiguous systems problems from the ground up, moving from concept to scalable execution.
  • Outstanding cross-functional communication and leadership skills, with the ability to bridge the gap between deeply technical engineering teams, AI researchers, and scientific product teams.
Preferred Qualifications
  • Domain knowledge or prior experience working with computational biology, genomics, transcriptomics, protein/molecular structures, healthcare, or scientific software.
  • Familiarity with building tools for scientific simulation, automated laboratory experiment management, or complex workflow orchestration.
  • Experience building unified computational frameworks (similar to our AIDO Foundry) that accelerate the development and deployment of AI-native platforms.

$250,000 - $350,000 a year

Join us as we embark on this journey to redefine the future of biology and medicine.

We are an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. GenBio AI participates in the U.S. Department of Homeland Security’s E-Verify program to confirm the employment eligibility of all newly hired employees. For more information on E-Verify, please visit www.e-verify.gov.

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