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Computational Modeling Simulation Multiphysics Jobs in Colorado

Arcfield

Mid-Level Physicist

Colorado Springs, CO · On-site

Responsibilities The physicist will perform scientific analysis and computational modeling to ... Position will require the use of scientific and engineering simulation software, in particular ...

Arcfield

Aerospace Engineer

Colorado Springs, CO · On-site

... modeling, simulation, and testing to assess weapon system performance and qualify weapon systems ... Experience with Computational Fluid Dynamics (CFD) Equal Pay Act This is the projected compensation ...

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Computational Modeling Simulation Multiphysics information

What is the difference between Computational Modeling Simulation Multiphysics vs Computational Engineer?

AspectComputational Modeling Simulation MultiphysicsComputational Engineer
CredentialsTypically requires degrees in engineering, physics, or related fields; certifications in simulation software are commonSimilar educational background; often holds engineering degrees and software certifications
Work EnvironmentPrimarily in R&D labs, engineering firms, or manufacturing settings focusing on complex simulationsInvolved in product development, software development, or systems design in various industries
Industry UsageUsed in aerospace, automotive, energy, and manufacturing for advanced simulationsApplied across industries for designing, analyzing, and optimizing systems and products

While both roles involve computational skills and engineering principles, Computational Modeling Simulation Multiphysics specializes in complex, multi-physics simulations, whereas Computational Engineer focuses on designing and implementing computational solutions across various engineering projects.

What are the key skills and qualifications needed to thrive as a Computational Modeling Simulation Multiphysics Engineer, and why are they important?

A strong background in physics, engineering, mathematics, and computational science—typically with an advanced degree—is essential for a Computational Modeling Simulation Multiphysics Engineer. Proficiency in simulation software such as ANSYS, COMSOL Multiphysics, MATLAB, and programming languages like Python or C++ is commonly required, along with familiarity with high-performance computing environments. Analytical thinking, problem-solving skills, and effective communication set standout professionals apart in this field. These capabilities enable accurate modeling of complex physical phenomena, efficient collaboration, and successful project outcomes in research and industry settings.

What is computational modeling simulation multiphysics?

Computational modeling simulation multiphysics refers to the use of computer-based models to simulate and analyze systems that involve multiple interacting physical phenomena—such as fluid dynamics, heat transfer, electromagnetics, and structural mechanics—all at once. This approach allows researchers and engineers to predict complex real-world behavior, optimize designs, and reduce the need for expensive prototypes. Multiphysics simulations are widely used in industries like aerospace, automotive, energy, and biomedical engineering, where accurate modeling of coupled physical processes is critical.

What are some common challenges faced by professionals in Computational Modeling Simulation Multiphysics roles, and how can they be addressed?

One of the main challenges in Computational Modeling Simulation Multiphysics roles is managing the complexity of integrating multiple physical phenomena, such as thermal, structural, and fluid dynamics, into a single simulation. This often requires a deep understanding of both the underlying physics and the numerical methods used by simulation software. Collaborating closely with domain experts and maintaining clear communication within multidisciplinary teams can help address these challenges. Additionally, staying updated with advances in simulation tools and best practices through continuous learning is key to overcoming technical hurdles and ensuring accurate results.
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Computational Modeling Simulation Multiphysics jobs near you
Principal Scientist, Computational Chemistry

Principal Scientist, Computational Chemistry

Cogent Biosciences

Boulder, CO • On-site

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 23 days ago

Job description

Who We Are:
Cogent Biosciences is a publicly traded biotechnology company focused on developing novel precision therapies to treat a broad range of patients with unmet medical needs. Cogent's lead program, bezuclastinib, is designed to selectively and potently inhibit exon 17 mutations found within the KIT receptor tyrosine kinase, including KIT D816V. KIT D816V is responsible for driving a rare and serious condition called Systemic Mastocytosis, and exon 17 mutations are also found in patients with gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. Bezuclastinib has exhibited promising initial data across all three trials: APEX in AdvSM, SUMMIT in NonAdvSM, and PEAK in GIST, including an encouraging safety profile across 600+ patients in single-agent and combination dosing.
The Role:
We are seeking an Experienced Computational Chemist who thrives at the intersection of molecular modeling, data-driven decision making, and innovative drug design. In this role, you will directly influence discovery programs by generating actionable structure-based insights, developing predictive models, and partnering with multidisciplinary teams to guide molecular design from hits to optimized leads. This is a full-time, on-site position based at our R&D facility in Boulder, Colorado.
Responsibilities:
  • Apply structure-based and ligand-based drug design methods-including docking, protein modeling, and a range of computational techniques-to support projects from hit discovery through lead optimization.
  • Collaborate with project team members, engaging them in iterative structure-based drug design cycles to generate hypotheses, evaluate targets, triage hits, and guide SAR exploration.
  • Present modeling insights clearly and effectively to cross-functional project teams, ensuring data is interpreted in the right context.
  • Develop, refine, and maintain robust computational workflows on HPC Linux environments, enabling scalable execution of large-scale simulations.
  • Train and mentor colleagues on computational chemistry tools, cheminformatics standards, data formats, and key workflow practices.

Qualifications:
  • Ph.D. in Computational Chemistry or a related field, with 3+ years of relevant industrial experience.
  • Expertise in structure-based design, docking, virtual screening, pharmacophore modeling, and other computational approaches for lead optimization.
  • Expertise in MOE modeling software, with working knowledge of other commercial and open-source computational chemistry platforms preferred.
  • Strong hands-on experience with cheminformatics platforms and tools, including Spotfire.
  • Strong programming skills with experience in building custom scripts or automated pipelines, is a plus.
  • Proficiency in Linux/UNIX, shell scripting, and HPC frameworks (e.g., SLURM, LSF, PBS/Torque).
  • Experience optimizing large computational workloads on cluster or cloud infrastructure.
  • Familiarity with molecular representations and cheminformatics standards (SMILES, SDF, descriptors, fragment-based encodings).
  • A solid publication record and excellent scientific communication skills.
  • Proven effectiveness working within cross-functional, data-driven scientific teams.

Salary Range:
$165k - 190k USD
Target Bonus: 15%
Exact compensation will vary based on skills, experience, and location.
Our Locations
Waltham, MA: Our headquarters is located in the Greater Boston life sciences community, with an open, collaborative office environment designed to support teamwork and connection. Employees benefit from convenient on-site amenities, including free on-site parking and gym facilities in the building.
Boulder, CO: Our Boulder location is home to Cogent's discovery research organization and a key scientific hub with strong leadership based on site. Situated in the greater Denver-Boulder biopharmaceutical corridor, this office plays a central role in advancing our discovery efforts and pipeline.
Our Offer To You
At Cogent Biosciences, we offer a competitive salary, bonus, and ongoing stock awards, alongside a benefits package that sets us apart. We cover 100% of medical, dental, and vision premiums for you and your family, and help reduce out-of-pocket costs by funding up to 75% of in-network deductibles. Our benefits also include a 401(k) match with immediate vesting, generous paid time off, 12 weeks of fully paid parental leave, paid family and medical leave for all employees regardless of location, and company-paid short-term disability coverage for up to 20 weeks. Additional perks like wellness programs, tuition reimbursement, and inclusive family-forming support help you thrive at work and beyond.
We are proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability, or any other status protected under federal, state, or local law. All employment is decided on the basis of qualifications, merit, and business need.

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