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Cmc Small Molecules Jobs (NOW HIRING)

Takeda

Director, Regulatory Site CMC

Boston, MA · On-site

$163K - $215K/yr

The Director Regulatory Site CMC ensures efficient and compliant management of regulatory change ... Supporting diverse modalities-including small molecules, biologics, and external manufacturing ...

Adecco

Project Manager II Scientific

Cambridge, MA · Hybrid

Adecco Healthcare & Life SciencesProject Manager II - MSAT CMC Development (Small Molecules) Hybrid (3 Days Onsite - Cambridge, MA) | Temp Role | Possible Extension Position Summary The Project ...

Glaukos

Sr. Scientist - Small Molecule

Aliso Viejo, CA · On-site

$97K - $133K/yr

... molecules to support all stages of drug development. * Troubleshoots and solves technical ... Supports authoring appropriate portions of CMC section of INDs, NDAs and prepares responses to ...

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Cmc Small Molecules information

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How much do cmc small molecules jobs pay per hour?

As of Jun 12, 2026, the average hourly pay for cmc small molecules in the United States is $26.19, according to ZipRecruiter salary data. Most workers in this role earn between $17.79 and $33.65 per hour, depending on experience, location, and employer.

What is a CMC job?

A CMC (Chemistry, Manufacturing, and Controls) job involves developing, manufacturing, and ensuring the quality of small molecule drugs. Professionals in this role typically work in pharmaceutical or biotech companies, focusing on regulatory compliance, process development, and documentation to support drug approval and production.

What are CMC Small Molecules?

CMC Small Molecules refers to the Chemistry, Manufacturing, and Controls (CMC) activities involved in the development and production of small molecule drugs. These are low molecular weight compounds, typically developed as medicines for a wide range of diseases. CMC encompasses the processes for ensuring that these drugs are manufactured consistently, safely, and to high-quality standards, including formulation, testing, stability, and compliance with regulatory guidelines. Professionals working in CMC Small Molecules are critical to bringing new pharmaceutical products from the laboratory to the market.

What is the difference between GMP and CMC?

In the context of CMC Small Molecules, GMP (Good Manufacturing Practice) refers to the regulations ensuring quality and safety during manufacturing, while CMC (Chemistry, Manufacturing, and Controls) encompasses the comprehensive documentation and processes involved in drug development and production. CMC includes activities like process development, quality control, and stability testing, all of which must comply with GMP standards to ensure product consistency and safety.

What is the difference between Cmc Small Molecules vs CMC Formulation Scientist?

AspectCmc Small MoleculesCMC Formulation Scientist
Required CredentialsBachelor's or Master's in Chemistry, Pharmaceutical Sciences, or related fields; GMP knowledgeBachelor's or Master's in Pharmaceutical Sciences, Chemistry, or related fields; formulation expertise
Work EnvironmentLaboratories, manufacturing facilities, R&D settingsLaboratories, formulation development labs, production environments
Employer & Industry UsagePharmaceutical companies, biotech firms, contract research organizationsPharmaceutical companies, biotech firms, contract manufacturing organizations

While both roles involve working within the pharmaceutical industry and require similar educational backgrounds, Cmc Small Molecules focuses on the development and manufacturing of small molecule drugs, emphasizing chemistry and process development. In contrast, CMC Formulation Scientists specialize in creating drug formulations, ensuring stability and delivery. Both roles are essential in bringing new drugs to market but differ in their specific focus areas and daily responsibilities.

What are the key skills and qualifications needed to thrive as a CMC (Chemistry, Manufacturing, and Controls) Small Molecules professional, and why are they important?

To thrive as a CMC Small Molecules professional, you need a strong background in chemistry, pharmaceutical sciences, and regulatory guidelines, usually supported by an advanced degree in a scientific discipline. Familiarity with analytical instrumentation, GMP manufacturing processes, and regulatory submission systems (such as eCTD) is crucial. Strong project management, problem-solving abilities, and effective cross-functional communication help individuals excel in this field. These skills ensure the successful development, scale-up, and regulatory approval of safe and effective small molecule pharmaceuticals.

What are CMC activities in pharma?

CMC activities in pharma refer to Chemistry, Manufacturing, and Controls processes involved in the development and production of small molecules. These activities include formulation development, process optimization, quality control, stability testing, and regulatory documentation to ensure product safety and efficacy. Professionals in this field often work with laboratory techniques, regulatory standards, and manufacturing protocols to support drug approval and commercialization.

What are some of the main challenges faced by CMC Small Molecules professionals during drug development projects?

CMC Small Molecules professionals often encounter challenges such as ensuring consistent product quality across different manufacturing scales, meeting strict regulatory requirements, and managing tight project timelines. Collaboration with cross-functional teams—including analytical, formulation, and regulatory groups—is essential for aligning on specifications and resolving technical issues. Staying adaptable and detail-oriented helps address unexpected process or analytical hurdles, which are common in the development and scale-up of small molecule therapeutics.

What is CMC in eCTD?

In the context of CMC Small Molecules, CMC refers to Chemistry, Manufacturing, and Controls, which are sections of the eCTD (electronic Common Technical Document) that provide detailed information on the drug's composition, manufacturing processes, quality control, and stability. These sections are essential for regulatory submissions to demonstrate product consistency and safety. Professionals in this field need to ensure accurate documentation and compliance with regulatory standards during the drug approval process.
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Cmc Small Molecules jobs near you
Infographic showing various Cmc Small Molecules job openings in the United States as of June 2026, with employment types broken down into 85% Full Time, and 15% Part Time. Highlights an 92% Physical, 3% Hybrid, and 5% Remote job distribution, with an average salary of $54,467 per year, or $26.2 per hour.
Director, CMC Project Management

Director, CMC Project Management

Sionna Therapeutics Inc

Waltham, MA • On-site

$210K - $230K/yr

Full-time

Posted 13 days ago

Job description

Description:

Sionna Therapeutics is a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for CF by developing novel medicines that normalize the function of the CFTR protein. Sionna’s goal is to deliver differentiated medicines for people living with CF that can restore their CFTR function to as close to normal as possible by directly stabilizing CFTR’s nucleotide-binding domain 1 (NBD1), which the company believes is central to potentially unlocking meaningful improvements in clinical outcomes and quality of life for people with CF. Leveraging over a decade of the co-founders’ extensive research on NBD1, the company is advancing a pipeline of novel small molecules engineered to correct the defects caused by the F508del genetic mutation, which resides in NBD1. Sionna is also developing a portfolio of complementary CFTR modulators that are designed to work synergistically with its NBD1 stabilizers to improve CFTR function.

Position Summary:

Sionna Therapeutics is seeking a Director, CMC Project Management who will be responsible for facilitating and coordinating the strategic planning, integration, and execution of the company’s CMC development programs across the portfolio. This position serves as a vital role within CMC, driving cross-functional alignment, integrated planning, and execution from pre-clinical development through commercial readiness.


Reporting to the Senior Vice President of CMC, this individual will partner closely with CMC, Clinical Drug Supply, Regulatory, Quality Assurance, Finance, and Program Leadership to ensure CMC programs are aligned with corporate goals and clinical development plans.


Responsibilities:

Program Management

  • Drive the creation and ongoing management of integrated program plans, including timelines, priorities, milestones, risk registers, and action plans.
  • Manage a portfolio of CMC projects, ensuring alignment with corporate goals and clinical development plans.
  • Support the development of clear, data-driven scenarios and strategic options that enable agility and well-informed decision-making.
  • Facilitate effective cross-functional team coordination, meeting management, and execution against deliverables.
  • Ensure consistent application of project management best practices, including project plans, dashboards, timelines, risk registers, and governance.
  • Identify, establish, and continuously improve project management processes, tools, metrics, and operating models across CMC teams to improve efficiency.

Operational Excellence

  • Ensure CMC project meetings and CMC governance meetings are agenda-driven and focused on efficient decision-making.
  • Coordinate and document agenda and meeting notes for meetings with internal and external stakeholders to ensure clear communication and expectations as well as efficient execution of CMC activities and CMC governance meetings.

Financial Management

  • Manage the CMC project budgets to ensure accurate forecasting, alignment with strategic priorities and accountability across CMC.
  • Facilitate the review and approval of CDMO scopes of work, purchase orders, and invoices.
Requirements:
  • Bachelor’s degree (advanced degree preferred) in Chemistry, Pharmaceutics, or related field.
  • 12+ years of experience in pharmaceutical or biotech industry, with at least 3 years of experience in CMC project management or related technical operations role or equivalent experience.
  • Experience with small molecule and solid oral dosage form development preferred.
  • PMP or PMI certification is beneficial but not required.
  • Experience collaborating with CDMO partners.
  • Demonstrated analytical, problem-solving, and scenario planning skills.
  • Exceptional organizational and communication skills and a demonstrated ability to work independently and collaboratively across all levels of the organization.
  • Curious, adaptable, and energizing leader adept at leading through change.
  • Champions and models the organization’s values, fostering a culture of quality, inclusion, and continuous improvement across all teams.
  • Proficiency with project management tools such as Smartsheet or OnePager preferred.
  • Ability to thrive in a fast-paced, dynamic environment with shifting priorities.

Salary Range: $210,000 – $230,000

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