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$26

$45

How much do cmc small molecules jobs pay per hour?

As of Jun 12, 2026, the average hourly pay for cmc small molecules in the United States is $26.19, according to ZipRecruiter salary data. Most workers in this role earn between $17.79 and $33.65 per hour, depending on experience, location, and employer.

What is a CMC job?

A CMC (Chemistry, Manufacturing, and Controls) job involves developing, manufacturing, and ensuring the quality of small molecule drugs. Professionals in this role typically work in pharmaceutical or biotech companies, focusing on regulatory compliance, process development, and documentation to support drug approval and production.

What are CMC Small Molecules?

CMC Small Molecules refers to the Chemistry, Manufacturing, and Controls (CMC) activities involved in the development and production of small molecule drugs. These are low molecular weight compounds, typically developed as medicines for a wide range of diseases. CMC encompasses the processes for ensuring that these drugs are manufactured consistently, safely, and to high-quality standards, including formulation, testing, stability, and compliance with regulatory guidelines. Professionals working in CMC Small Molecules are critical to bringing new pharmaceutical products from the laboratory to the market.

What is the difference between GMP and CMC?

In the context of CMC Small Molecules, GMP (Good Manufacturing Practice) refers to the regulations ensuring quality and safety during manufacturing, while CMC (Chemistry, Manufacturing, and Controls) encompasses the comprehensive documentation and processes involved in drug development and production. CMC includes activities like process development, quality control, and stability testing, all of which must comply with GMP standards to ensure product consistency and safety.

What is the difference between Cmc Small Molecules vs CMC Formulation Scientist?

AspectCmc Small MoleculesCMC Formulation Scientist
Required CredentialsBachelor's or Master's in Chemistry, Pharmaceutical Sciences, or related fields; GMP knowledgeBachelor's or Master's in Pharmaceutical Sciences, Chemistry, or related fields; formulation expertise
Work EnvironmentLaboratories, manufacturing facilities, R&D settingsLaboratories, formulation development labs, production environments
Employer & Industry UsagePharmaceutical companies, biotech firms, contract research organizationsPharmaceutical companies, biotech firms, contract manufacturing organizations

While both roles involve working within the pharmaceutical industry and require similar educational backgrounds, Cmc Small Molecules focuses on the development and manufacturing of small molecule drugs, emphasizing chemistry and process development. In contrast, CMC Formulation Scientists specialize in creating drug formulations, ensuring stability and delivery. Both roles are essential in bringing new drugs to market but differ in their specific focus areas and daily responsibilities.

What are the key skills and qualifications needed to thrive as a CMC (Chemistry, Manufacturing, and Controls) Small Molecules professional, and why are they important?

To thrive as a CMC Small Molecules professional, you need a strong background in chemistry, pharmaceutical sciences, and regulatory guidelines, usually supported by an advanced degree in a scientific discipline. Familiarity with analytical instrumentation, GMP manufacturing processes, and regulatory submission systems (such as eCTD) is crucial. Strong project management, problem-solving abilities, and effective cross-functional communication help individuals excel in this field. These skills ensure the successful development, scale-up, and regulatory approval of safe and effective small molecule pharmaceuticals.

What are CMC activities in pharma?

CMC activities in pharma refer to Chemistry, Manufacturing, and Controls processes involved in the development and production of small molecules. These activities include formulation development, process optimization, quality control, stability testing, and regulatory documentation to ensure product safety and efficacy. Professionals in this field often work with laboratory techniques, regulatory standards, and manufacturing protocols to support drug approval and commercialization.

What are some of the main challenges faced by CMC Small Molecules professionals during drug development projects?

CMC Small Molecules professionals often encounter challenges such as ensuring consistent product quality across different manufacturing scales, meeting strict regulatory requirements, and managing tight project timelines. Collaboration with cross-functional teams—including analytical, formulation, and regulatory groups—is essential for aligning on specifications and resolving technical issues. Staying adaptable and detail-oriented helps address unexpected process or analytical hurdles, which are common in the development and scale-up of small molecule therapeutics.

What is CMC in eCTD?

In the context of CMC Small Molecules, CMC refers to Chemistry, Manufacturing, and Controls, which are sections of the eCTD (electronic Common Technical Document) that provide detailed information on the drug's composition, manufacturing processes, quality control, and stability. These sections are essential for regulatory submissions to demonstrate product consistency and safety. Professionals in this field need to ensure accurate documentation and compliance with regulatory standards during the drug approval process.
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Cmc Small Molecules jobs near you
Infographic showing various Cmc Small Molecules job openings in the United States as of June 2026, with employment types broken down into 85% Full Time, and 15% Part Time. Highlights an 92% Physical, 3% Hybrid, and 5% Remote job distribution, with an average salary of $54,467 per year, or $26.2 per hour.

Dir, Sr Director, Analytical Sciences / CMC

NWRPros

Seattle, WA • On-site

Full-time

Posted 22 days ago

Job description

Commercial Readiness | Biologics & Small Molecules | Analytical Strategy
Position Overview
A Seattle biopharmaceutical company is seeking an accomplished Analytical Sciences leader to drive CMC analytical strategy across development and commercial programs. This role requires a deeply experienced technical authority capable of establishing robust, inspection-ready analytical frameworks with immediate impact.
The successful candidate will bring significant biologics expertise, with additional experience in small molecule programs preferred. This role demands a seasoned leader who can independently define analytical specifications, oversee product characterization, and ensure commercial-grade robustness in release and stability programs.
This is a critical leadership position within a growing organization operating with lean resources — requiring immediate subject matter expertise and high reliability.

Core Responsibilities
Analytical & CMC Leadership
  • Establish and oversee drug substance and drug product specifications
  • Lead analytical method development, qualification, validation, and lifecycle management
  • Direct product characterization, critical quality attribute assessments, and comparability strategies
  • Define analytical strategy supporting IND, BLA, and NDA submissions
  • Ensure commercial readiness of release and stability methods
Operational & Organizational Leadership
  • Lead and mentor a growing analytical sciences team
  • Oversee timelines, budgets, and resource planning
  • Drive analytical priorities aligned with CMC and corporate objectives
  • Support commercial launch preparation and lifecycle management activities
  • Contribute to third-party contract negotiations and supply agreements
External Collaboration & Regulatory
  • Oversee analytical method transfer and validation at CMOs
  • Review and approve protocols, reports, and investigations
  • Lead analytical contributions to regulatory filings and agency interactions
  • Ensure global regulatory compliance and inspection readiness
Required Background
  • PhD (strongly preferred) or MD in Analytical Chemistry, Biochemistry, Biology, or related scientific field
  • 15+ years of analytical sciences and CMC leadership experience in biotech/pharma
  • Deep expertise in biologics; small molecule analytical experience desirable
  • Demonstrated experience supporting commercial-stage products
  • Strong knowledge of GMPs, comparability protocols, and regulatory CMC requirements
  • Experience with complex modalities (e.g., conjugates, oncology-related platforms, integrated biologic systems) highly desirable
  • Experience in highly technical, science-driven organizations (large pharma or advanced biotech environments preferred)
Leadership Profile
  • Technical authority capable of operating independently with minimal onboarding
  • “Hard-core” CMC mindset — focused on robustness, reproducibility, and regulatory defensibility
  • High standards around quality, reliability, and scientific excellence
  • Strong executive communication skills
  • Comfortable building infrastructure in resource-constrained environments
Additional Information
  • On-site presence strongly preferred
  • Limited travel (~10%)
  • Relocation may be considered