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Cmc Small Molecules Jobs in Bothell, WA (NOW HIRING)

Omeros Corp.

Director, Quality Control

Seattle, WA · On-site

... class small-molecule and protein therapeutics for large-market and orphan indications, with ... CMC teams * Partner with internal and external stakeholders to transfer, qualify and validate ...

Omeros

Director, Quality Control

Seattle, WA · On-site

... class small-molecule and protein therapeutics for large-market and orphan indications, with ... CMC teams * Partner with internal and external stakeholders to transfer, qualify and validate ...

Immunome, Inc.

Director, Quality Operations

Bothell, WA · On-site

Experience with small molecules and biologics is required. Responsibilities Quality Operations ... Participate in Quality Management Review meetings, as needed. * Assist in updating CMC sections of ...

Immunome, Inc.

Director, Quality Operations

Bothell, WA · On-site

Experience with small molecules and biologics is required. Responsibilities Quality Operations ... Participate in Quality Management Review meetings, as needed. * Assist in updating CMC sections of ...

Omeros Corp.

Research Associate I

Seattle, WA · On-site

... our CMC team. The Research Associate, Analytical Sciences will support drug substance and drug ... small-molecule therapeutics for both large-market and orphan indications, with a focus on ...

Omeros

Research Associate I

Seattle, WA · On-site

... our CMC team. The Research Associate, Analytical Sciences will support drug substance and drug ... small-molecule therapeutics for both large-market and orphan indications, with a focus on ...

All JobsCmc Small Molecules JobsCmc Small Molecules Jobs in Bothell, WA

Cmc Small Molecules information

See Bothell, WA salary details

$16

$29

$50

How much do cmc small molecules jobs pay per hour?

As of Aug 26, 2026, the average hourly pay for cmc small molecules in Bothell, WA is $29.27, according to ZipRecruiter salary data. Most workers in this role earn between $19.90 and $37.64 per hour, depending on experience, location, and employer.

What is CMC Small Molecules?

CMC Small Molecules refers to the Chemistry, Manufacturing, and Controls (CMC) activities involved in the development and production of small molecule drugs. These are low molecular weight compounds, typically developed as medicines for a wide range of diseases. CMC encompasses the processes for ensuring that these drugs are manufactured consistently, safely, and to high-quality standards, including formulation, testing, stability, and compliance with regulatory guidelines. Professionals working in CMC Small Molecules are critical to bringing new pharmaceutical products from the laboratory to the market.

What skills and qualifications are needed to thrive as a CMC Small Molecules professional?

To thrive as a CMC Small Molecules professional, you need a strong background in chemistry, pharmaceutical sciences, and regulatory guidelines, usually supported by an advanced degree in a scientific discipline. Familiarity with analytical instrumentation, GMP manufacturing processes, and regulatory submission systems (such as eCTD) is crucial. Strong project management, problem-solving abilities, and effective cross-functional communication help individuals excel in this field. These skills ensure the successful development, scale-up, and regulatory approval of safe and effective small molecule pharmaceuticals.

What are the main challenges faced by CMC Small Molecules professionals during drug development projects?

CMC Small Molecules professionals often encounter challenges such as ensuring consistent product quality across different manufacturing scales, meeting strict regulatory requirements, and managing tight project timelines. Collaboration with cross-functional teams—including analytical, formulation, and regulatory groups—is essential for aligning on specifications and resolving technical issues. Staying adaptable and detail-oriented helps address unexpected process or analytical hurdles, which are common in the development and scale-up of small molecule therapeutics.

What is the difference between Cmc Small Molecules vs CMC Formulation Scientist?

AspectCmc Small MoleculesCMC Formulation Scientist
Required CredentialsBachelor's or Master's in Chemistry, Pharmaceutical Sciences, or related fields; GMP knowledgeBachelor's or Master's in Pharmaceutical Sciences, Chemistry, or related fields; formulation expertise
Work EnvironmentLaboratories, manufacturing facilities, R&D settingsLaboratories, formulation development labs, production environments
Employer & Industry UsagePharmaceutical companies, biotech firms, contract research organizationsPharmaceutical companies, biotech firms, contract manufacturing organizations

While both roles involve working within the pharmaceutical industry and require similar educational backgrounds, Cmc Small Molecules focuses on the development and manufacturing of small molecule drugs, emphasizing chemistry and process development. In contrast, CMC Formulation Scientists specialize in creating drug formulations, ensuring stability and delivery. Both roles are essential in bringing new drugs to market but differ in their specific focus areas and daily responsibilities.

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Cmc Small Molecules jobs near you

Principal Scientist, Chemical Development

Immunome, Inc.

Bothell, WA • On-site

Full-time

Posted 4 days ago

Job description

Position Overview

We are seeking an experienced Principal Scientist, Chemical Development to join our dynamic team to help advance our pipeline of innovative targeted cancer therapies. The successful candidate will apply their expertise in small molecule process development and manufacturing to support a variety of modalities in the Immunome pipeline with a focus on small molecule linker-payload targets for ADCs. This person will play a key role in leading challenging drug candidate process development programs, enabling treatment of patients in need. 

Responsibilities

Leadership 

  • Provide technical leadership as a key member of the chemical development team while maintaining alignment with the company's goals and objectives.  
  • Function as the technical lead on at least one program while also functioning as an individual technical contributor.  
  • Provide guidance and leadership to external partners working towards the successful advancement of antibody drug conjugates, radiopharmaceuticals, and other lead programs.  
  • Support programs at the bench as an individual contributor as needed.  

Technical Expertise 

  • Leverage knowledge and experience in the development and execution of robust and scalable small molecule synthetic processes.  
  • Devise and evaluate alternative routes of synthesis with the aim of developing robust and efficient routes to APIs while reducing cost of goods (COGs) and shortening manufacturing lead times.  
  • Develop robust data packages for technical transfer of processes for manufacturing partners at external CMOs.  
  • Maintain knowledge of the current state of the art in synthetic methods utilized for the construction of complex molecules.  
  • Carry out thorough analytical data collection both as an individual contributor in the lab as well as via oversight and review of data collected at our external partners.   
  • Contribute to authoring relevant sections of various regulatory documents (IND, IMPD, NDA, briefing books, etc.) and provide SME support for related regulatory inquiries.    

Cross-Functional Collaboration  

  • Execute the integrated CMC regulatory strategies for pipeline programs.  
  • Collaborate with research, regulatory affairs, and CMC teams to ensure seamless coordination of activities.  
  • Provide feedback to research on synthetic routes and raw materials that are CMC friendly. 
  • Foster strong collaborations with internal and external stakeholders.  
  • Engage colleagues in discovery chemistry to provide CMC input of target molecules under evaluation for future development.  

  Innovation 

  • Stay abreast of the latest advancements in synthetic methodology as well as new technologies and methodologies to enhance our capabilities. 
  • Advance Immunome's intellectual property portfolio.    

Quality and Compliance 

  • Ensure compliance with relevant regulatory guidelines and industry standards for chemical development processes.  
  • Uphold high-quality standards and address any compliance issues.

Qualifications

  • PhD in Synthetic Organic Chemistry or similar with a minimum of 7 years of industry experience leading small molecule and/or linker-payload programs, or equivalent combination of education and experience.  
  • Experience as a technical lead overseeing tech transfer, process development and implementation of processes for manufacture at internal and/or external manufacturers is a plus. 
  • Occasional evening and/or weekend commitment. 
  • Ability to travel domestically and internationally (5-15%). 

  Knowledge and Skills

  • Ability to design cost effective robust manufacturing processes for complex small molecule targets as well as troubleshoot and solve complex technical challenges quickly.  
  • Brings a collaborative and open-minded attitude when working with various internal and external teammates.  
  • Meticulous and detail-oriented scientist with the ability to operate as an individual contributor at the bench while also managing external partners.  
  • Proficient in generating robust and reliable analytical data utilizing various technologies in a hands-on capacity as well as evaluation of analytical data generated at external partners.  
  • Proficient in writing technical reports and formulating presentations   
  • Ability to develop cross functional relationships with discovery chemistry and other pre-clinical groups.  
  • Experience in leading and managing technology transfers to third party process development and manufacturing partners.  
  • Knowledge of cGMP requirements and ICH guidelines related to CMC small molecule drug-substance development and manufacturing.  
  • Track record of working closely with cross-functional teams in a biopharmaceutical or pharmaceutical environment.  
  • Excellent interpersonal and communication skills. 

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