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Clinical Trial Program Manager Jobs in Boston, MA

C4 Therapeutics Inc

Clinical Trial Manager

Watertown, MA · On-site

$138K - $153K/yr

C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO ... Manage the cross-functional study team and CRO/vendor(s) related to all aspects of clinical trial ...

C4-Therapeutics-Inc

Clinical Trial Manager

Watertown, MA · On-site

$139 - $153/hr

Clinical Trial Manager Full Time Management Watertown, MA, US 23 days ago Requisition ID: 1144 ... C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO ...

Frontier Medicines

Clinical Trial Manager

Boston, MA · Hybrid

$120K - $150K/yr

... program strategy and cross-functional leadership. This is a hybrid role based in our Boston, MA ... Clinical Trial Manager or Clinical Project Management experience, ideally supporting oncology ...

Clinovo

Clinical Trial Manager

Waltham, MA · On-site

The Role The Clinical Trial Manager (CTM) will be a key contributor to the successful execution of clinical trials and will play an important role in building and maintaining relationships with ...

Frontier Medicines

Clinical Trial Manager

Boston, MA · On-site

$120K - $150K/yr

... program strategy and cross-functional leadership. This is a hybrid role based in our Boston, MA ... Clinical Trial Manager or Clinical Project Management experience, ideally supporting oncology ...

Frontier Medicines

Clinical Trial Manager

Boston, MA · On-site

$120K - $150K/yr

... program strategy and cross-functional leadership. This is a hybrid role based in our Boston, MA ... Clinical Trial Manager or Clinical Project Management experience, ideally supporting oncology ...

Biogen

Clinical Trial Manager

Cambridge, MA · On-site

$117K - $157K/yr

As a Clinical Trial Manager, you will be a vital part of the PO&T team within the Implantable ... Fitness & Wellness programs including a fitness reimbursement * Short- and Long-Term Disability ...

Kymera Therapeutics

Clinical Trial Manager

Watertown, MA · On-site

$115K - $200K/yr

Responsible for management of vendors to support clinical trial execution * Plan, execute, and lead study-specific meetings (e.g., internal core team meetings, investigator meetings, etc), as needed

Biogen

Clinical Trial Manager

Cambridge, MA · Hybrid

$117K - $157K/yr

As a Clinical Trial Manager, you will be a vital part of the PO&T team within the Implantable ... Fitness & Wellness programs including a fitness reimbursement * Short- and Long-Term Disability ...

Skyhawk Therapeutics

Clinical Trial Manager

Waltham, MA · On-site +1

$140K - $200K/yr

Clinical Trial Manager Skyhawk Therapeutics seeks an experienced Clinical Trial Manager (title commensurate with experience) who is looking to work in a fast paced, growth mindset organization ...

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How much do clinical trial program manager jobs pay per hour?

As of Sep 6, 2026, the average hourly pay for clinical trial program manager in Boston, MA is $67.92, according to ZipRecruiter salary data. Most workers in this role earn between $55.10 and $76.54 per hour, depending on experience, location, and employer.

What does a clinical trial program manager do?

A Clinical Trial Program Manager oversees the planning, execution, and completion of clinical trials within an organization. They coordinate cross-functional teams, manage timelines and budgets, ensure compliance with regulatory guidelines, and maintain the quality and integrity of clinical data. Their role is essential for the successful development of new medical treatments, as they bridge communication between stakeholders, monitor progress, and address any issues that arise during trials.

What are some common challenges faced by clinical trial program managers, and how can they be addressed?

Clinical Trial Program Managers often encounter challenges such as managing complex timelines, coordinating multiple stakeholders, and ensuring regulatory compliance across different study sites. These challenges can be addressed by implementing robust project management tools, maintaining clear and consistent communication with cross-functional teams, and staying updated on regulatory requirements. Developing strong organizational skills and fostering collaborative relationships with investigators, sponsors, and regulatory bodies are also key to overcoming obstacles in this role.

What are the key skills and qualifications needed to thrive as a clinical trial program manager, and why are they important?

To thrive as a Clinical Trial Program Manager, you need strong project management skills, a background in life sciences or healthcare, and experience with clinical research regulations such as GCP, often supported by a relevant degree and certifications like PMP or ACRP. Familiarity with clinical trial management systems (CTMS), electronic data capture (EDC) platforms, and regulatory submission tools is typically required. Exceptional leadership, communication, and problem-solving abilities help you coordinate teams and manage complex stakeholder relationships. These skills ensure that clinical trials are conducted efficiently, compliantly, and successfully, leading to reliable study outcomes and regulatory approval.

What are popular job titles related to Clinical Trial Program Manager jobs in Boston, MA?

For Clinical Trial Program Manager jobs in Boston, MA, the most frequently searched job titles are:

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The top searched job categories for Clinical Trial Program Manager jobs in Boston, MA are:

Clinical Trial Program Manager jobs near you

Clinical Trial Manager/Senior Clinical Trial Manager

Oruka Therapeutics

Waltham, MA • On-site

Full-time

Re-posted 29 days ago

Job description

About Us:
Oruka Therapeutics (Nasdaq: ORKA) is developing novel biologics designed to set a new standard for the treatment of chronic skin diseases. Oruka's mission is to offer patients suffering from chronic skin diseases like plaque psoriasis the greatest possible freedom from their condition by achieving high rates of complete disease clearance with dosing as infrequently as once or twice per year. Oruka is advancing a proprietary portfolio of potentially best-in-class antibodies that were engineered by Paragon Therapeutics and target the core mechanisms underlying plaque psoriasis and other dermatologic and inflammatory diseases. For more information, visit www.orukatx.com
As we build our core team, we're seeking top talent in different functional areas who are not just looking for a job, but an opportunity to be part of something bigger. Someone who is passionate about making a difference and eager to contribute to establishing an engaged, inclusive, and positive company culture.
Job Title: Clinical Trial Manager/Senior Clinical Trial Manager
Location: Hybrid 3 days/week if located near office in Waltham, MA or Menlo Park, CA will be required. Remote may be considered.
About Us:
Oruka Therapeutics (Nasdaq: ORKA) is developing novel biologics designed to set a new standard for the treatment of chronic skin diseases. Oruka's mission is to offer patients suffering from chronic skin diseases like plaque psoriasis the greatest possible freedom from their condition by achieving high rates of complete disease clearance with dosing as infrequently as once or twice per year. Oruka is advancing a proprietary portfolio of potentially best-in-class antibodies that were engineered by Paragon Therapeutics and target the core mechanisms underlying plaque psoriasis and other dermatologic and inflammatory diseases. For more information, visit www.orukatx.com
As we build our core team, we're seeking top talent in different functional areas who are not just looking for a job, but an opportunity to be part of something bigger. Someone who is passionate about making a difference and eager to contribute to establishing an engaged, inclusive, and positive company culture.
Role Overview:
Will ensure trial compliance, regulatory alignment, and operational efficiency while collaborating with cross-functional teams to advance Oruka's clinical pipeline. Independently manage the clinical trial by effectively planning and executing the study to ensure quality of deliverables within the specified budget and timeframe. May serve as the clinical functional lead and lead clinical trial initiatives for Oruka's cutting-edge dermatology treatments.
Key Responsibilities:
  • Clinical Trial Management:
    • Lead and manage multiple clinical trials from initiation through to completion, ensuring adherence to study timelines and budgets.
    • Collaborate with investigators, vendors, and cross-functional teams to ensure study execution and operational excellence.
    • Oversee the preparation and review of trial-related documentation, including protocols, informed consent forms (ICFs), case report forms (CRFs), and study reports.
    • In partnership with Program Management, develop and drive cross functional study timelines related to trial setup and execution.
  • Team Leadership:
    • Drive the cross functional internal study team ensuring appropriate alignment, risk management and coordination across all participating functions.
    • Successfully interface with Data Management, Biostatistics and Clinical Development to ensure seamless monitoring and data cleaning initiatives to meet study deliverables and timelines
    • Foster a collaborative team environment focused on operational efficiency and continuous improvement.
  • Regulatory and Compliance Oversight:
    • Ensure that clinical trials are conducted in compliance with all applicable regulations, including FDA, EMA, and ICH-GCP guidelines.
    • Support the preparation and submission of clinical trial applications, including INDs, NDAs, and other regulatory documents with functional leads.
    • Manage interactions with Regulatory Affairs and external vendors to ensure timely submissions and approvals.
  • Budget and Resource Management:
    • Develop and manage clinical trial budgets, ensuring efficient use of resources and timely financial reporting.
    • Monitor and control trial costs to ensure alignment with project forecasts and company objectives.
    • Negotiate contracts and budgets with clinical vendors and investigators.
  • Vendor and Site Management:
    • Oversee the selection and management of clinical vendors (CROs, laboratories, etc.) and ensure they meet performance expectations.
    • Develop strong relationships with clinical sites and external partners to ensure aggressive site startup, high-quality data collection and trial conduct.
    • Perform risk assessment and management, addressing issues proactively to mitigate operational issues.

Qualifications:
  • Bachelor's or Master's degree in life sciences or a related field.
  • 5-7+ years of experience in clinical operations, with a focus on managing complex clinical trials.
  • Expertise in GCP and regulatory requirements.
  • Strong leadership and team management skills.

Compensation:
  • An appropriate financial package will be developed for the successful candidate to include a competitive base salary and equity, with a performance-related bonus opportunity.
  • The anticipated salary range for Manager level is $146,000 - $161,000 and Sr. Manager level is $161,000 - $187,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc. Oruka is a multi-state employer and this salary range may not reflect positions that work in other states.

Job Location:
  • Hybrid 3 days/week if located near office in Waltham, MA or Menlo Park, CA will be required. Remote may be considered.

We're looking forward to hearing how you can contribute to our team and mission. Join us in shaping the future of our company and making a real impact every day.
Salary Range for the Role
$146,000-$187,000 USD
What We Offer:
  • A chance to be part of a vibrant startup culture where your work can directly impact bringing new medicines to patients.
  • Competitive salary and benefits package.
  • A supportive and inclusive team environment where everyone is encouraged to bring their authentic selves to work.
  • Opportunities for professional growth and development.

Apply