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Cell Culture Supervisor Jobs (NOW HIRING)

$60 - $80/hr

Establishing and maintaining recombinant cell cultures * Adapting and optimizing assay protocols ... Rather than supervising a large research organization, the successful candidate will have the ...

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Part-Time Senior Scientist - Cell Biology

Boston, MA โ€ข On-site

Aphios Corporation
Biotechnology Research and Developmentย โ€ขย 11 - 50 employees

$60 - $80/hr

Other

Posted 7 days ago


Job description

Part-Time Senior Scientist โ€“ Cell Biology & In Vitro Assays

Aphios Corporation, a clinical-stage biotechnology company, is seeking an experienced PhD-level Scientist / Senior Scientist with strong handsโ€‘on expertise in mammalian cell culture and cell-based assay development.

We are particularly interested in experienced biotechnology/pharmaceutical scientists seeking a flexible partโ€‘time or consulting role, including senior scientists transitioning from fullโ€‘time industry careers, as well as experienced academic research scientists in the Boston/Cambridge scientific community who would welcome the opportunity to contribute directly to therapeutic development.

This is not primarily a management position. We are looking for a scientist who still enjoys experimental design, handsโ€‘on laboratory work, troubleshooting, data interpretation, and scientific problemโ€‘solving at the bench.

The scientistโ€™s initial responsibility will be to establish, optimize, and conduct an in vitro antiโ€‘nausea assay using recombinant stomachโ€‘derived cells, including:

  • Establishing and maintaining recombinant cell cultures
  • Adapting and optimizing assay protocols
  • Designing appropriate experimental controls
  • Conducting concentrationโ€‘ and doseโ€‘response studies
  • Evaluating therapeutic candidates and formulations
  • Assessing assay sensitivity, reproducibility, and variability
  • Analyzing and interpreting experimental results
  • Establishing standardized protocols and SOPs

Substantially in parallel, the scientist will contribute to in vitro research supporting Aphiosโ€™ GLPโ€‘1 and Alzheimerโ€™s disease programs, potentially including assays involving:

  • Alpha-secretase activity
  • Protein kinase C (PKC) activation and signaling
  • Inflammatory and antiโ€‘inflammatory pathways
  • Cytokine expression and release
  • Cell viability and cytotoxicity
  • Cellular signaling and mechanistic studies
  • Doseโ€‘response evaluation of therapeutic candidates
Qualifications Required
  • PhD in Cell Biology, Molecular Biology, Biochemistry, Pharmacology, Neuroscience, Physiology, or a closely related discipline
  • Strong handsโ€‘on mammalian cellโ€‘culture experience
  • Demonstrated experience developing and conducting cellโ€‘based assays
  • Experience with recombinant or engineered cell systems
  • Ability to independently establish, optimize, and troubleshoot assays
  • Strong experimental design, quantitative analysis, and scientific documentation skills
  • Desire to remain actively involved in laboratory research
Particularly Valuable Experience
  • Pharmaceutical or biotechnology R&D
  • Gastrointestinal biology or nausea/emesis pharmacology
  • GLPโ€‘1 biology or receptor signaling
  • Alzheimerโ€™s disease/neurodegeneration
  • PKC and alpha-secretase biology
  • Cytokine and inflammatory assays
  • ELISA, immunoassays, Western blotting, fluorescence, luminescence, or reporter assays
  • Cell viability and cytotoxicity testing
An Opportunity for Experienced Scientists

This position may be particularly attractive to a senior industry scientist seeking to remain scientifically active on a flexible basis, or an experienced academic scientist interested in applying deep laboratory expertise directly to therapeutic development.

Rather than supervising a large research organization, the successful candidate will have the opportunity to personally establish important assays, generate and interpret data, and influence the scientific direction of multiple development programs.

The position is structured as partโ€‘time / consulting, with flexibility based on experience, availability, and program requirements.

About Aphios

Aphios is advancing a diversified therapeutic portfolio that includes a planned Phase III clinical program for Zindolยฎ, planned Phase IIb programs in opioid addiction and chronic epilepsy, and additional therapeutic programs progressing through INDโ€‘enabling development.

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Aphios logo

About Aphios

Sourced by ZipRecruiter

Industry

Biotechnology research and development

Company size

11 - 50 Employees

Headquarters location

Woburn, MA, US

Year founded

1993

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