Bioinformatics Associate Jobs in Silver Spring, MD

Job Summary:
Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications. They are seeking an Associate Director of Artificial Intelligence, Modeling, and Data to lead the strategic development and deployment of AI/ML solutions for federal health agencies, overseeing projects that bridge computational science and clinical research.
Responsibilities:
• Architect and execute a comprehensive AI/ML strategy that aligns Axle’s technical capabilities with the NIH Strategic Plan for Data Science (2025–2030).
• Define the long-term vision for integrating Generative AI, Large Language Models (LLMs), and Agentic Workflows into federal research environments, moving beyond static analysis to active, AI-assisted discovery.
• Spearhead the evolution of the Polus platform, transitioning it from a robust image analysis tool into a fully integrated, multi-modal research ecosystem.
• Oversee the roadmap for new feature development, ensuring scalability, security, and interoperability across cloud environments (AWS/GCP/Azure) using containerized architectures (Docker/Kubernetes).
• Establish and enforce rigorous AI Governance frameworks.
• Operationalize the NIST AI Risk Management Framework (RMF) across all projects to ensure fairness, interpretability, and compliance with federal ethical standards.
• Lead 'Gap Analysis' and 'Risk Management' exercises to ensure all AI deployments are trustworthy and transparent.
• Direct the design and implementation of high-throughput data pipelines capable of ingesting and analyzing petabyte-scale datasets (genomics, proteomics, EHR).
• Ensure these systems adhere to FAIR data principles (Findable, Accessible, Interoperable, Reusable), facilitating seamless data sharing across NIH institutes and global research centers.
• Oversee the development of predictive models for translational science, focusing on 'de-risking' drug discovery and clinical trial design.
• Guide technical teams in the application of deep learning techniques to identify molecular targets, predict therapeutic outcomes, and simulate clinical scenarios (Digital Twins).
• Optimize MLOps and DevSecOps processes to ensure the rapid, secure deployment of models from prototype to production.
• Champion a culture of 'automation first,' reducing time-to-insight for researchers by streamlining the transition from Jupyter notebooks to containerized, cloud-native services.
• Partner with the Growth and Capture teams to drive new business acquisition.
• Serve as the Lead Solution Architect for major proposal efforts ($50M+), authoring technical volumes, developing win themes, and creating compelling solution graphics that demonstrate Axle’s technical differentiation.
• Personally write key sections of technical proposals, including the 'Technical Approach,' 'Staffing Plan,' and 'Risk Mitigation' volumes.
• Galvanize relationships with key federal stakeholders (Project Officers, CIOs, Lab Chiefs).
• Act as the primary technical liaison, translating complex agency requirements into deliverable technical solutions and presenting these visions in competitive 'Black Hat' sessions and oral presentations.
• Cultivate a high-performance, interdisciplinary team culture.
• Manage and mentor a diverse group of data scientists, bioinformaticians, and software engineers, fostering an environment of psychological safety where 'expert' scientific knowledge seamlessly integrates with 'agile' engineering practices.
• Drive continuous learning and upskilling initiatives.
• Establish internal 'Communities of Practice' for AI and Data Science, ensuring that Axle’s workforce remains at the bleeding edge of technologies like Graph Neural Networks and Federated Learning.
• Democratize access to AI tools within the client environment.
• Lead efforts to create 'low-code/no-code' interfaces and training programs that empower non-technical NIH researchers to utilize advanced analytics independently.
Qualifications:
Required:
• Ph.D. in Computer Science, Bioinformatics, Computational Biology, Data Science, or a related quantitative discipline is highly preferred to ensure peer-level credibility with NIH scientists.
• Alternatively, a Master’s degree in one of the above fields with exceptional, demonstrated leadership experience in a federal or research-intensive setting will be considered.
• 8–10+ years of progressive experience in data science, AI/ML engineering, or computational biology, with a focus on high-dimensional data.
• 3–5+ years of leadership experience managing cross-functional teams (e.g., managing both PhD researchers and software developers) in a matrixed organization.
• Demonstrated experience with Federal Business Development, including writing technical proposals and supporting capture activities for contracts valued at $15M+.
• Proven track record of delivering complex AI/ML solutions in a regulated environment, with specific familiarity with HIPAA, FedRAMP, or NIST AI RMF compliance.
• Expert-level understanding of Deep Learning frameworks (PyTorch, TensorFlow), Classical Machine Learning (Scikit-Learn), and Generative AI architectures (Transformers, LLMs, RAG).
• Proficiency in Python (primary) and R (secondary); familiarity with Java or C++ (for Polus backend optimization) is a strong plus.
• Extensive experience with Cloud-Native AI pipelines on AWS (SageMaker, HealthLake), GCP (Vertex AI, BigQuery), or Azure. Knowledge of the NIH STRIDES initiative and cloud economics is essential.
• Mastery of big data technologies (Spark, Databricks) and workflow orchestration tools (Airflow, Nextflow, Cromwell).
• Strong knowledge of containerization (Docker, Kubernetes), CI/CD pipelines (GitHub Actions, Jenkins), and model monitoring/governance tools.
• Experience with advanced visualization tools (DeepZoom, WebGL) and platform development (building APIs, microservices).
Preferred:
• NIH Ecosystem Experience: Direct experience working with NIH, NCATS, NIAID, or similar federal health agencies. Understanding of the specific data challenges within the federal health sector is highly valued.
• Open Source Leadership: Contributions to or leadership of open-source scientific software projects. Specific familiarity with the Polus platform or the National COVID Cohort Collaborative (N3C) data enclave is a distinct advantage.
• NIST AI RMF Practitioner: Demonstrated experience implementing the NIST AI Risk Management Framework (Map, Measure, Manage, Govern) in a real-world setting.
• Domain Expertise: Specialized knowledge in High-Content Imaging, Cheminformatics, Genomics, or Real-World Data (RWD) analytics.
Company:
At Axle, we are driven by the mission to accelerate discovery and enhance organizational outcomes by revolutionizing operations with our innovative solutions. Founded in 2002, the company is headquartered in Rockville, USA, with a team of 501-1000 employees. The company is currently Late Stage.