Bayesian Jobs in California (NOW HIRING)

Job Function Summary:
Applies advanced computational, computer science, data science, statistical, and quantitative modeling principles, together with domain expertise in pharmacology, drug development, and translational science, to perform research and technology development supporting model-informed drug development (MIDD). Responsibilities include the design, development, implementation, validation, and application of computational models, machine learning approaches, simulation frameworks, and quantitative decision-support tools used to advance drug regimen development and clinical translation. The position integrates diverse preclinical, clinical, and real-world datasets to develop predictive models that support regimen optimization, dose selection, trial design, and translational decision-making. Research activities may include pharmacometric modeling, quantitative systems pharmacology (QSP), mechanistic and Bayesian modeling, artificial intelligence and machine learning methods, statistical analyses, and development of computational workflows and scientific software. This specialty exists for positions whose primary responsibility is to conduct independent quantitative research and use computational and data science technologies to advance biomedical and translational research.
Generic Scope
Technical leader with a high degree of knowledge in the overall field and recognized expertise in specific areas; problem-solving frequently requires analysis of unique issues / problems without precedent and / or structure. May manage programs that include formulating strategies and administering policies, processes, and resources; functions with a high degree of autonomy.
Custom Scope
The Savic Integrated Pharmacology Laboratory at UCSF seeks a senior quantitative scientist to lead the development and application of advanced computational, statistical, pharmacometric, and machine learning methodologies to support model-informed drug development (MIDD) within the PReDiCTR-TB Consortium. The incumbent will apply expertise in pharmacometrics, quantitative systems pharmacology, AI/ML, computational biology, and translational modeling to develop predictive frameworks that inform regimen optimization, dose selection, clinical trial design, and translational decision-making for infectious disease drug development. The position requires scientific leadership across multiple complex projects and collaboration with academic, industry, and regulatory stakeholders. The incumbent will independently design, develop, validate, and deploy quantitative models and computational tools that integrate preclinical, clinical, and real-world datasets, and will contribute to publications, grant applications, and strategic scientific initiatives across the consortium.
Responsibilities
DUTIES & ESSENTIAL JOB FUNCTIONS
Identify the functions or tasks that employees in the job perform. The essential functions should state the purpose of the work and the results to be accomplished, rather than how the function is performed. Of the tasks listed, what percentage of time is devoted to each? The more time employees spend on a function, the more likely it is that the function is essential. Generally, include those functions that account for 10% or more of the work, i.e., key items that contribute significantly to the achievement of the job. The functions should add up to 100%.
of time
Essential Function (Yes/No)
Key Responsibilities
(To be completed by Supervisor)
30
Yes
Quantitative Modeling & Simulation
Lead development of PK/PD, mechanistic, Bayesian, QSP, and AI-enabled models
Design predictive frameworks for TB regimen optimization
Develop translational strategies linking preclinical and clinical data
25
Yes
Computational Research & Data Integration
Integrate multi-source datasets
Develop computational workflows
Apply machine learning and statistical methods
15
Yes
Scientific Leadership
Guide modeling strategy
Collaborate with external investigators
Influence scientific decision making
15
Yes
Publications, Grants & Scientific Communication
Manuscripts
Conference presentations
Grant development
15
Yes
Mentoring & Technical Leadership
Mentor trainees
Lead interdisciplinary project teams
Establish best practices
0
0
0
0
0
0
100%
(To update total %, enter the amount of time in whole numbers (without the % symbol - e.g., 15, 20) then highlight the total sum (e.g., 1%) at the bottom of the column and press F9. The total sum should add up to 100%.)
Qualifications
Required Qualifications

• Bachelor's degree in Computer / Computational / Data Science, or Domain Sciences with computer / computational / data specialization or equivalent experience.
• Minimum 5 years relevant experience
• Advanced knowledge of pharmacometrics, quantitative pharmacology, statistical modeling, and computational science
• Demonstrated expertise in model-informed drug development (MIDD)
• Experience developing mechanistic, PK/PD, Bayesian, or machine learning models
• Advanced programming skills in Python and/or R
• Ability to integrate large-scale biological, clinical, and translational datasets
• Demonstrated scientific leadership and independent research capability
• Ability to communicate complex quantitative concepts to scientific and non-scientific audiences
• Experience managing multiple concurrent research projects

Preferred Qualifications

• Master's degree in Computer / Computational / Data Science, or Domain Sciences with computer / computational / data specialization preferred.
• Postdoctoral or industry experience in quantitative drug development
• QSP, AI/ML
• Pharmacogenomics, Toxicokinetics
• Clinical trial simulation, Infectious disease modeling
• TB experience, Regulatory interactions
• Grant writing experience