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Apheresis Rn Jobs in Orlando, FL (NOW HIRING)

Registered Nurse (RN)

Orlando, FL · On-site

$35 - $45/hr

The OneBlood Registered Nurse (RN), under the direction of the Chief Medical Officer and the ... Performs all phases of therapeutic apheresis procedures and documentation, per OneBlood protocol ...

Performs apheresis procedures as needed in emergency and on-call situations * Coordinates closely with nurses at various hospitals to arrange therapeutic apheresis treatments in conjunction with ...

Performs apheresis procedures as needed in emergency and on-call situations * Coordinates closely with nurses at various hospitals to arrange therapeutic apheresis treatments in conjunction with ...

Performs apheresis procedures as needed in emergency and on-call situations * Coordinates closely with nurses at various hospitals to arrange therapeutic apheresis treatments in conjunction with ...

Performs apheresis procedures as needed in emergency and on-call situations * Coordinates closely with nurses at various hospitals to arrange therapeutic apheresis treatments in conjunction with ...

Apheresis Rn information

See Orlando, FL salary details

$18

$41

$68

How much do apheresis rn jobs pay per hour?

As of Aug 25, 2026, the average hourly pay for apheresis rn in Orlando, FL is $41.53, according to ZipRecruiter salary data. Most workers in this role earn between $31.39 and $48.46 per hour, depending on experience, location, and employer.

What is an apheresis RN?

Apheresis RNs are registered nurses who specialize in performing apheresis procedures, which involve removing specific components from a patient's blood, such as plasma, platelets, or white blood cells. They work closely with physicians and other healthcare professionals to monitor patients, operate apheresis machines, and ensure the safety and comfort of those undergoing treatment. These nurses are trained in both the technical and patient care aspects of apheresis and often work in hospitals, blood banks, or specialized outpatient clinics.

What does an apheresis RN do?

An apheresis RN has the training practice therapeutic apheresis. This procedure is a part of a variety of clinical specialties, including hematology, oncology, rheumatology, and neurology. Apheresis involves removing and separating blood components to use in treatment (directly or indirectly). Your responsibilities include using a machine to withdraw blood from the cubital fossa of the arm, upon which it then performs the separation procedures, and watching patients to identify potential adverse reactions. You educate patients and families on disease management and healthy living choices. As an apheresis RN, you perform your duties in clinical settings, including in general wards, intensive care, outpatient settings, and specialist clinics.

What are the key skills and qualifications needed to thrive as an apheresis RN, and why are they important?

To thrive as an Apheresis RN, you need a solid background in nursing with a current RN license, experience in hematology or oncology, and specialized knowledge of apheresis procedures. Familiarity with apheresis machines (such as Spectra Optia or COBE), strict protocol adherence, and possibly certification like the Certified Apheresis Nurse (CAN) credential are typically required. Strong attention to detail, compassionate patient care, and effective communication are crucial soft skills for this role. These competencies ensure safe, accurate procedures and positive patient outcomes in a highly specialized clinical setting.

What are some unique challenges an apheresis RN may encounter during patient procedures?

Apheresis RNs often work with patients who have complex or critical medical conditions, requiring careful monitoring for adverse reactions during procedures. They must be adept at troubleshooting equipment and responding quickly to complications such as hypotension, allergic reactions, or vascular access issues. The role also involves coordinating with physicians, laboratory staff, and other nurses to ensure patient safety and optimal outcomes. Adaptability and strong communication skills are essential, as patient needs and protocols can change rapidly in this specialized field.

What is the difference between Apheresis Rn vs Blood Bank Rn?

AspectApheresis RnBlood Bank Rn
CertificationsRN license, Apheresis certificationRN license, Blood bank certification
Work EnvironmentMobile units, hospitals, clinics for apheresis proceduresHospital blood banks, laboratories
Job DutiesPerforming apheresis procedures, donor managementBlood processing, testing, component preparation

Both Apheresis Rns and Blood Bank Rns are vital in blood collection and processing. Apheresis Rns specialize in collecting specific blood components via apheresis machines, often working in mobile or clinical settings. Blood Bank Rns focus on blood processing, testing, and storage within hospital labs. While their roles overlap in blood product management, their work environments and certifications differ slightly, making each role unique in the blood donation and transfusion process.

What are the most commonly searched types of Apheresis Rn jobs in Orlando, FL?

The most popular types of Apheresis Rn jobs in Orlando, FL are:

What are popular job titles related to Apheresis Rn jobs in Orlando, FL?

For Apheresis Rn jobs in Orlando, FL, the most frequently searched job titles are:

What job categories do people searching Apheresis Rn jobs in Orlando, FL look for?

The top searched job categories for Apheresis Rn jobs in Orlando, FL are:

What cities near Orlando, FL are hiring for Apheresis Rn jobs?

Cities near Orlando, FL with the most Apheresis Rn job openings:

Infographic showing various Apheresis Rn job openings in Orlando, FL as of August 2026, with employment types broken down into 72% Full Time, 14% Part Time, and 14% Contract. Highlights an 100% In-person job distribution, with an average salary of $86,374 per year, or $41.5 per hour.

Registered Nurse (RN)

OneBlood

Orlando, FL • On-site

$35 - $45/hr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 3 days ago


OneBlood rating

6.4

Company rating: 6.4 out of 10

Based on 57 frontline employees who took The Breakroom Quiz

645th of 893 rated healthcare providers


Job description

The OneBlood Registered Nurse (RN), under the direction of the Chief Medical Officer and the Manager or Director Nursing, has the responsibility to perform clinical apheresis procedures.

The list of essential functions, as outlined herein, is intended to be representative of the duties and responsibilities performed within this classification. It is not necessarily descriptive of any one position in the class. The omission of an essential function does not preclude management from assigning duties not listed herein if such functions are a logical assignment to the position.

  • Performs all phases of therapeutic apheresis procedures and documentation, per OneBlood protocol following physician’s orders.
  • Ensures safe and appropriate care of patient in accordance with applicable regulations and HIPAA guidelines
  • Administers blood and blood products, utilizing apheresis equipment and following appropriate protocol
  • Performs apheresis procedures as needed in emergency and on-call situations
  • Coordinates closely with nurses at various hospitals to arrange therapeutic apheresis treatments in conjunction with other required therapy to allow continuity of patient care
  • Assess patient status relative to therapeutic apheresis, prior to and during procedures, and evaluate patient medication for compatibility and safety of apheresis procedure and determine when to contact the physician.

To perform this job successfully, an individual must be able to perform each essential duty and responsibility satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required.

EDUCATION AND/OR EXPERIENCE: Associate’s degree from an accredited college or university and one (1) year of related experience; or equivalent combination of education, training, and/or experience.

CERTIFICATES, LICENSES, REGISTRATIONS AND DESIGNATIONS: Current and valid Florida RN license, current BLS CPR certification, and a valid and clear driver’s license.

KNOWLEDGE, SKILLS AND ABILITIES:

  • Ability to effectively obtain peripheral access, utilize dialysis catheters, fistulas, grafts or power ports
  • Ability to read and interpret technical procedures and patient related documentation
  • Ability to document on hospital records procedural information and patient tolerance
  • Ability to effectively discuss procedures and medical related issues within scope with patient, families, nurses, and physicians
  • Operates company vehicles in compliance with all applicable regulations.
  • Ability to speak, write, read, and understand English
  • Ability to add and subtract, multiply and divide in all units of measure, using whole numbers, common fractions and decimals
  • Ability to solve practical problems and deal with a variety of variables in situations where only limited standardization exists
  • Ability to interpret a variety of technical instructions furnished in written, oral, diagram or schedule form
  • Basic computer skills including knowledge of Microsoft Office applications.
  • Ability to commute with personal transportation.

PHYSICAL REQUIREMENTS: The physical demands described here are representative of those that must be must by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Tasks involve the periodic performance of moderately physically demanding work, usually involving lifting, carrying, pushing and/or pulling of moderately heavy objects and materials (up to 50 pounds). Tasks that require moving objects of significant weight require the assistance of another person and/or use of proper techniques and moving equipment. Tasks may involve some climbing, stooping, kneeling, crouching, or crawling.

ENVIRONMENTAL REQUIREMENTS: The work environment characteristics described here are representative of those an employee may encounter while performing the essential functions of this job.

Functions are regularly performed inside and/or outside with potential for exposure to adverse conditions, such as inclement weather, atmospheric elements and pathogenic substances. Performance of this job could expose the employee to blood-borne pathogens. The noise level in the work environment is usually moderate.

Company Description

OneBlood is a not-for-profit 501(c)(3) community asset responsible for providing safe, available and affordable blood to more than 200 hospital partners and their patients. The service area of OneBlood includes Florida, Southern Georgia, North Carolina and South Carolina.

The OneBlood name is a constant reminder of the collective power we share to save another person’s life.


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