ZipRecruiter

Log In

1

Analytical Method Development Scientist Jobs in Boston, MA

next page

Showing results 1-20

All JobsAnalytical Method Development Scientist JobsAnalytical Method Development Scientist Jobs in Boston, MA

Analytical Method Development Scientist information

See Boston, MA salary details

$24

$45

$70

How much do analytical method development scientist jobs pay per hour?

As of Sep 11, 2026, the average hourly pay for analytical method development scientist in Boston, MA is $45.71, according to ZipRecruiter salary data. Most workers in this role earn between $34.23 and $52.74 per hour, depending on experience, location, and employer.

What does an analytical method development scientist do?

An Analytical Method Development Scientist is responsible for designing, developing, and validating analytical methods used to test and analyze chemical compounds, pharmaceuticals, or other materials. They ensure that the methods are accurate, reliable, and compliant with regulatory standards. This role involves working with advanced laboratory instruments, troubleshooting analytical issues, and documenting procedures for use in research, quality control, or manufacturing environments.

What are the key skills and qualifications needed to thrive as an analytical method development scientist?

To thrive as an Analytical Method Development Scientist, a strong background in chemistry, analytical techniques, and method validation—often supported by a relevant degree in chemistry or pharmaceutical sciences—is essential. Familiarity with laboratory instrumentation such as HPLC, GC, MS, and software for data analysis, as well as knowledge of regulatory guidelines like ICH and FDA, is typically required. Attention to detail, problem-solving abilities, and effective communication are vital soft skills for success in this role. These skills ensure reliable method development, regulatory compliance, and effective collaboration within multidisciplinary scientific teams.

What are the typical challenges faced by an analytical method development scientist when transferring methods to quality control or manufacturing teams?

One common challenge for Analytical Method Development Scientists is ensuring that newly developed analytical methods are robust and reproducible when transferred to quality control or manufacturing teams. Differences in equipment, sample matrices, or operator technique can impact results, so thorough method validation and clear documentation are essential. Scientists often work closely with cross-functional teams to provide training, troubleshoot issues, and adapt protocols as needed. Successfully managing these transitions helps maintain product quality and regulatory compliance.

What is the difference between Analytical Method Development Scientist vs Analytical Chemist?

AspectAnalytical Method Development ScientistAnalytical Chemist
Primary FocusDeveloping and validating new analytical methodsPerforming routine analysis and testing
Work EnvironmentResearch labs, R&D departmentsQuality control labs, manufacturing facilities
CredentialsBachelor's or Master's in Chemistry or related field; experience in method developmentBachelor's degree in Chemistry or related field; experience in analytical testing

While both roles involve analytical testing, the Analytical Method Development Scientist primarily focuses on creating and validating new analytical methods, often in research settings. In contrast, the Analytical Chemist typically performs routine testing to ensure product quality in manufacturing or quality control labs.

What are popular job titles related to Analytical Method Development Scientist jobs in Boston, MA?

For Analytical Method Development Scientist jobs in Boston, MA, the most frequently searched job titles are:

What job categories do people searching Analytical Method Development Scientist jobs in Boston, MA look for?

The top searched job categories for Analytical Method Development Scientist jobs in Boston, MA are:

Analytical Method Development Scientist jobs near you
Infographic showing various Analytical Method Development Scientist job openings in Boston, MA as of September 2026, with employment types broken down into 79% Full Time, and 21% Contract. Highlights an 95% In-person, and 5% Hybrid job distribution, with an average salary of $95,081 per year, or $45.7 per hour.

Senior / Principal Scientist Analytical Method Development Lead

Woburn, MA • On-site

Terrestrial Bio, Inc.
See more jobs at Terrestrial Bio, Inc.external

$125K - $180K/yr

Other

Posted 3 days ago

New

Job description

Terrestrial Bio

Location: Allston, MA and Woburn, MA

About Terrestrial Bio, Inc.

Terrestrial is transforming the delivery of next-generation therapies, starting with GLP-1.

Terrestrial's proprietary Tacterra™ microarray patch (MAP) and applicator platform consists of a patch resembling an adhesive bandage, which is applied with a preloaded applicator and removed after a few minutes. Once applied, each patch delivers bioactive tips into the skin, which dissolve quickly into the body, rapidly releasing their therapeutic payload. Designed for self-administration, the temperature-stable Tacterra™ platform enables precise, controlled delivery of a wide range of therapeutics without medical sharps or refrigeration.

Terrestrial has generated strong clinical and in-vivo proof of concept across multiple molecules. For more information, visit www.terrestrialbio.com.

Why this role

We are seeking an Analytical Method Development (AMD) Lead to drive the analytical method development, qualification, and validation strategy for the microneedle array patch (MAP) program. This individual will lead the development of release and characterization methods including HPLC/UPLC, LC-MS, and functional assays and own the analytical method lifecycle from Phase 2 through Phase 3 IND and commercialization.

This is a senior technical leadership role for a scientist with deep peptide/biologic analytical expertise and a track record of building robust, regulatory-compliant methods.

What you'll do

  • Lead analytical method development for release and characterization assays including RP-HPLC/UPLC purity, content, SEC, and impurity characterization by LC-MS.

  • Define and execute the analytical method validation strategy per ICH Q2(R2) and Q14.

  • Develop the Validation Master Plan (VMP) governing method qualification, validation, transfer, and lifecycle management.

  • Establish the impurity characterization strategy for GLP-1 peptide, including oxidation, deamidation, and related substances.

  • Lead method transfers to QC and to/from external CROs.

  • Define the analytical control strategy and specifications for Phase 2 Tox and Phase 3 clinical lots.

  • Support characterization of reference standards and establishment of bridging strategies.

  • Author analytical sections of regulatory submissions (IND, CMC) and serve as analytical SME during inspections.

  • Guide the development of the potency/functional assay strategy in collaboration with pre-clinical and formulation teams.

  • Mentor and develop method development scientists; provide technical leadership across the AMD function.

Who you are

  • Ph.D. in Analytical Chemistry, Biochemistry, or related field with 6+ years relevant experience, OR M.S. with 8+ years in pharmaceutical/biotech analytical method development.

  • Deep expertise in HPLC/UPLC method development for peptides or biologics.

  • Hands-on experience with LC-MS for impurity characterization and structural analysis.

  • Demonstrated experience leading method validation under ICH Q2(R2)/Q14.

  • Experience developing analytical control strategies and specifications for clinical-stage products.

  • Strong knowledge of ICH Q6A, Q3A/B/C/D, and FDA/EMA CMC expectations.

Preferred Qualifications

  • Experience with GLP-1 peptides or semaglutide analytical methods.

  • Experience with microneedle/transdermal or drug-device combination products.

  • Prior experience defining potency or cell-based functional assay strategies.

  • Experience supporting IND/BLA filings and regulatory interactions.

  • Experience building and scaling an analytical method development function.

Key Competencies

  • Deep technical expertise combined with strategic program thinking.

  • Strong leadership and mentoring capability.

  • Excellent scientific writing and regulatory communication.

  • Ability to balance scientific rigor with program timelines in a fast-paced environment.

Compensation:

The anticipated base salary range for this position is $125,000 - $180,000. Actual compensation will be determined based on a variety of factors including experience, qualifications, and internal equity.

Onsite expectations:

The majority of our roles at Terrestrial are either onsite or hybrid, which allows us to meet both business and team needs. Candidates applying must be willing to be onsite 4-5 days per week.

Location:

Woburn, MA and our new, custom facility in Allston MA planned for Q4 of 2026.

At Terrestrial, we’re bringing together exceptional talent to drive our product development forward. We value collaboration, curiosity, and a dynamic work environment. We aim to recruit, employ, train, compensate and promote regardless of race, religion, color, national origin, sex, gender identity or expression, sexual orientation, disability, age, or veteran status.

#J-18808-Ljbffr

Apply