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Analytical Method Development Scientist Jobs in Boston, MA

Vrtx

Analytical Development Senior Scientist

Boston, MA

$122K - $183K/yr

General Summary Vertex is seeking a Senior Research Scientist to join Analytical Development in ... Lead chromatographic method development, qualification, and validation activities. * Partner with ...

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Analytical Method Development Scientist information

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$24

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$70

How much do analytical method development scientist jobs pay per hour?

As of Jul 28, 2026, the average hourly pay for analytical method development scientist in Boston, MA is $45.71, according to ZipRecruiter salary data. Most workers in this role earn between $34.23 and $52.74 per hour, depending on experience, location, and employer.

What does an Analytical Method Development Scientist do?

An Analytical Method Development Scientist is responsible for designing, developing, and validating analytical methods used to test and analyze chemical compounds, pharmaceuticals, or other materials. They ensure that the methods are accurate, reliable, and compliant with regulatory standards. This role involves working with advanced laboratory instruments, troubleshooting analytical issues, and documenting procedures for use in research, quality control, or manufacturing environments.

What are the key skills and qualifications needed to thrive as an Analytical Method Development Scientist, and why are they important?

To thrive as an Analytical Method Development Scientist, a strong background in chemistry, analytical techniques, and method validation—often supported by a relevant degree in chemistry or pharmaceutical sciences—is essential. Familiarity with laboratory instrumentation such as HPLC, GC, MS, and software for data analysis, as well as knowledge of regulatory guidelines like ICH and FDA, is typically required. Attention to detail, problem-solving abilities, and effective communication are vital soft skills for success in this role. These skills ensure reliable method development, regulatory compliance, and effective collaboration within multidisciplinary scientific teams.

What are the typical challenges faced by an Analytical Method Development Scientist when transferring methods to quality control or manufacturing teams?

One common challenge for Analytical Method Development Scientists is ensuring that newly developed analytical methods are robust and reproducible when transferred to quality control or manufacturing teams. Differences in equipment, sample matrices, or operator technique can impact results, so thorough method validation and clear documentation are essential. Scientists often work closely with cross-functional teams to provide training, troubleshoot issues, and adapt protocols as needed. Successfully managing these transitions helps maintain product quality and regulatory compliance.

What is the difference between Analytical Method Development Scientist vs Analytical Chemist?

AspectAnalytical Method Development ScientistAnalytical Chemist
Primary FocusDeveloping and validating new analytical methodsPerforming routine analysis and testing
Work EnvironmentResearch labs, R&D departmentsQuality control labs, manufacturing facilities
CredentialsBachelor's or Master's in Chemistry or related field; experience in method developmentBachelor's degree in Chemistry or related field; experience in analytical testing

While both roles involve analytical testing, the Analytical Method Development Scientist primarily focuses on creating and validating new analytical methods, often in research settings. In contrast, the Analytical Chemist typically performs routine testing to ensure product quality in manufacturing or quality control labs.

What are popular job titles related to Analytical Method Development Scientist jobs in Boston, MA? For Analytical Method Development Scientist jobs in Boston, MA, the most frequently searched job titles are:
What job categories do people searching Analytical Method Development Scientist jobs in Boston, MA look for? The top searched job categories for Analytical Method Development Scientist jobs in Boston, MA are:
Analytical Method Development Scientist jobs near you
Infographic showing various Analytical Method Development Scientist job openings in Boston, MA as of July 2026, with employment types broken down into 88% Full Time, 8% Part Time, and 4% Contract. Highlights an 85% Physical, 5% Hybrid, and 10% Remote job distribution, with an average salary of $95,081 per year, or $45.7 per hour.
Analytical Development Scientist (HPLC)

Analytical Development Scientist (HPLC)

Thermo Fisher Scientific

Bedford, MA • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 26 days ago

Thermo Fisher Scientific rating

7.7

Company rating: 7.7 out of 10

Based on 419 frontline employees who took The Breakroom Quiz

199th of 535 rated manufacturers

Job description

Work Schedule
Standard (Mon-Fri)
Environmental Conditions
Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)
Job Description
Do you have a passion for innovative ideas and groundbreaking discoveries? With over $1 billion invested annually in R&D, at Thermo Fisher Scientific you'll help solve some of the world's toughest challenges, from giving cancer patients hope, ensuring safe drinking water and helping law enforcement tackle cases through forensics. We empower our teams to put science into meaningful action and give our R&D colleagues the autonomy, resources, and tools they need to take science a step beyond.
Location: On-site Bedford, MA. Relocation assistance is NOT provided.
  • Must be legally authorized to work in the United States without sponsorship.
  • Must be able to pass a comprehensive background check, which includes a drug screening.

Discover Impactful Work:
We are seeking an innovative and highly motivated Analytical Development Scientist to join our R&D organization. In this role, you will contribute to the development and commercialization of next-generation analytical technologies with a primary focus on HPLC products and processes supporting critical to quality attributes in the biotechnology and biopharmaceutical industries.
You will work in a collaborative, cross-functional environment to develop robust products, characterize product performance, and accelerate new product introductions that address critical customer needs. Experience or familiarity with analytical chromatography product development is highly desirable.
Key Responsibilities:
  • Develop, optimize, and apply analytical HPLC methods to characterize product performance and support new product development.
  • Design and execute experiments to evaluate product attributes relevant to regulated bioprocessing, biologics development, and drug-quality monitoring.
  • Develop analytical strategies to assess critical-to-quality attributes, including purity, aggregation, charge variants, identity, concentration, or other relevant product and process attributes.
  • Generate, analyze, and interpret complex analytical datasets to guide technical decisions, product requirements, and development strategy.
  • Evaluate HPLC product performance across relevant use conditions, sample types, workflows, and customer applications.
  • Support product development activities, including feasibility studies, prototype evaluation, design verification, process optimization, technology transfer, and commercialization.
  • Collaborate closely with Product Management, Applications, Manufacturing, Quality, Regulatory, Commercial, and other R&D teams throughout the product lifecycle.
  • Support method transfer, manufacturing validation, and new product introduction activities through robust experimentation and clear documentation.
  • Author technical reports, protocols, SOPs, test methods, presentations, and other scientific documentation.
  • Identify technical risks, troubleshoot analytical challenges, and adapt experiments based on emerging data.
  • Contribute to innovation initiatives by identifying new applications, technologies, customer needs, and product opportunities.
  • Present technical findings and recommendations to internal stakeholders and, when appropriate, external customers.

How You Will Get Here:
Minimum Qualifications
  • Ph.D. or M.S. with 3+ years of experience in Analytical Chemistry, Biochemistry, Chemical Engineering, Biotechnology, Pharmaceutical Sciences, or a related scientific field preferred; Bachelor's with 5+ years of experience in Analytical Chemistry, Biochemistry, Chemical Engineering, Biotechnology, Pharmaceutical Sciences, or a related scientific field acceptable.
  • Hands-on experience with analytical chromatography systems, preferably HPLC or UHPLC.
  • Strong understanding of analytical chromatography principles, method development, method optimization, and data interpretation.
  • Experience developing or applying analytical methods used to characterize biological molecules, biopharmaceutical products, or process-related attributes.
  • Experience designing experiments, analyzing analytical data, troubleshooting methods, and drawing technically sound conclusions.
  • Demonstrated ability to work effectively in cross-functional technical teams.
  • Strong technical writing, documentation, and communication skills.

Preferred Qualifications
  • Experience in a regulated, GMP-adjacent, quality-control, analytical development, process development, or biopharmaceutical laboratory environment.
  • Familiarity with analytical methods used to monitor critical-to-quality attributes in biologics or bioprocessing workflows.
  • Experience with one or more analytical characterization techniques such as SEC, ion exchange chromatography, reversed-phase chromatography, HIC, affinity chromatography, ELISA, IC, DLS, UV-Vis, CE, or mass spectrometry.
  • Familiarity with analytical method lifecycle concepts, including method qualification, validation, transfer, robustness, precision, accuracy, specificity, and system suitability.
  • Knowledge of FDA, ICH, USP, or other regulatory guidance related to drug quality, analytical methods, or biologics characterization.
  • Experience with downstream purification, bioprocessing, biologics development, chromatography media, chromatography columns, or analytical workflow development.
  • Experience supporting technical transfer, manufacturing validation, product launch, or customer-facing technical activities is a plus, but direct product development experience is not required.
  • Ability to identify issues, troubleshoot experiments, adapt quickly based on data, and seek input when needed.

What We're Looking For:
  • Scientific curiosity and a passion for innovation.
  • Strong analytical, problem-solving, and critical-thinking skills.
  • Ability to manage multiple priorities in a fast-paced R&D environment.
  • Collaborative mindset with strong interpersonal skills.
  • Attention to detail and commitment to high-quality experimental execution.
  • Customer-focused approach to product and method development.
  • Comfort working with ambiguity and translating technical data into practical recommendations.
  • Continuous-improvement mindset and willingness to learn new technologies, applications, and workflows.

We offer competitive remuneration, annual incentive plan bonus scheme, healthcare, company 401k, and a range of employee benefits! Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation.
Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate based on race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other legally protected status. We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform critical job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.
Compensation and Benefits
The salary range estimated for this position based in Massachusetts is $92,000.00-$135,000.00.
This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
  • A choice of national medical and dental plans, and a national vision plan, including health incentive programs
  • Employee assistance and family support programs, including commuter benefits and tuition reimbursement
  • At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
  • Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
  • Employees' Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount

For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards

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