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ViiV Healthcare is a global specialty HIV company, the only one that is 100% focused on researching and delivering new medicines for people living with, and at risk of, HIV. ViiV is highly mission-driven in our unrelenting commitment to being a trusted partner for all people living with and affected by HIV. Our aim is to think, act, and connect differently through a focus on education and treatment for HIV. We go to extraordinary lengths to deliver the sorts of breakthroughs, both in treatments, care solutions and communities, that really count and take a holistic approach to HIV through developing and supporting sustainable community programs and improving access to care. We are fully committed to push through every challenge until HIV/AIDS is eradicated. ViiV has played a significant part in delivering breakthroughs that have turned HIV into a manageable health condition. We offer the largest portfolio of HIV medicines available anywhere, and we continue our work to cater for the widest possible range of needs in response to the HIV epidemic.

We are aware of how much is at stake for those affected by HIV and we show up 100% committed to the patients every day. Our work culture is fast-paced, diverse, inclusive, competitive, and caring. But ViiV isn't just somewhere to work - it's a place to belong, an invitation to bring your very best, and a team full of impact-driven team members who are hungry to make a difference.

While we have been improving lives of HIV patients for 30 years, this is an especially exciting time to be at ViiV, as we evaluate novel approaches to treatment and prevention that could further reduce the impact of HIV on individuals and communities.

This Scientific Leader, Nonclinical Drug Discovery Modeling contributes to Model-Informed Drug Discovery (MIDD) across ViiV Discovery by developing and applying fit-for-purpose modeling and simulation approaches that enable rapid, data-driven decision-making for HIV drug discovery programs. This discovery-focused individual contributor leverages mechanistic and translational modeling approaches (e.g., PBPK, IVIVE, PK/PD) to integrate experimental data and generate predictive insights that support compound progression from target validation through candidate selection across diverse modalities, including small molecules, biologics, ADCs, LNPs, and PROTACs. Working within established modeling frameworks and in close partnership with DMPK, Medicinal Chemistry, Biology, and Clinical Pharmacology, the role translates ADME, pharrnacokinetic, and pharmacological data into early dose predictions across multiple formulations and routes of administration, helping project teams rapidly

identify and advance the highest-quality candidates for clinical development.

This role will be based out of Branford, CT & is eligible for a domestic relocation package.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Apply fit-for-purpose modeling and simulation approaches to support decision-making across HIV discovery programs.
• Develop and execute mechanistic and translational models (e.g., PBPK, IVIVE, PK/PD) to support dose prediction, compound optimization, and candidate selection.
• Integrate experimental data into predictive workflows and translate ADME, PK, PD, and translational data into actionable project insights.
• Apply modeling expertise across diverse modalities, formulations, and routes of administration, including long-acting therapies.
• Guide program teams toward the identification and advancement of high-quality clinical candidates.
• Contribute to modeling workflows, computational tools, and reproducible coding practices.

We are looking for professionals with these required skills to achieve our goals:

• MS Degree & 7 plus years of experience or PhD & 4 plus years of experience (postgraduation) supporting drug discovery programs
• Experience with modeling platforms (e.g., SimCYP, GastroPlus, WinNonlin, etc.) and basic scripting experience (e.g., R MATLAB, Python) development
• Ability to apply mechanistic modeling approaches to support discovery programs and to progress rapid decisions
• Experience with integrating experimental datasets into modeling workflows
• Familiarity with reproducible coding practices and version control
• Experience in PK/PD, PBPK, or IVIVE modeling approaches
• Ability to interpret results and communicate to cross-functional teams

If you have the following characteristics, it would be a plus:

• PhD & 6 plus years of drug discovery experience
• Experience working across teams, including partnering with internal and external experts
• Excellent written, verbal, and presentation skills, including experience communicating scientific concepts to cross-functional teams and stakeholders
• Strong data visualization and numerical analysis capabilities are highly valued

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program ViiV offers US employees. All ViiV employees receive the same benefits options and plans as GSK employee.

At ViiV Healthcare, we will not rest until we leave no person living with HIV behind. Until the 40 million people living with HIV is down to zero, we will continue searching for new ways to limit the impact of HIV.

We are the only pharmaceutical company solely focused on combating, preventing, and ultimately eradicating HIV and AIDS. At ViiV Healthcare, we do things differently. Born out of a partnership between GSK and Pfizer in 2009, with Shionogi joining in 2012, we are determined to help end the HIV epidemic. We are guided by our mission to leave no person living with HIV behind and it is this mission that unites our employees located across the globe. We combine expertise in research, manufacturing, policy and more to push the boundaries of what people think is possible in HIV treatment and care. As a result of our connection with GSK, we are able to draw on their proud history and resources. This means that you would receive all the employee benefits offered by GSK.

Living our mission of leaving no person living with HIV behind means keeping inclusion and diversity at the heart of everything we do - from our breakthrough innovation, to our diverse portfolio of medicines as well as the work we do to partner with HIV communities.

Having a truly inclusive culture where we’re all able to be ourselves and feel like we belong will make us an even stronger team, better able to perform as a business and deliver on our mission to leave no person living with HIV behind.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at - usrecruitment.adjustments@gsk.com

ViiV is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

ViiV does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact ViiV's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to ViiV. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and ViiV. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of ViiV. ViiV shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, ViiV may be required to capture and report expenses ViiV incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure ViiV’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/