The Associate Director/Director, Protein Sciences will collaborate with the Century’s Research team in order to harness the power of adult stem cells to develop curative therapies for cancer. The incumbent’s key responsibilities will include developing and employing protein separation and analytical methods for therapeutic protein production and characterization. They will also develop optimal methods and processes for efficient protein candidate biophysical characterization. This role will require extensive interaction with internal and external partners to leverage best-in-class expertise and capabilities in protein production.
Responsibilities: • This individual will be responsible for developing and instituting protein separation and analytical methods for high-quality protein production • This includes analytical methods for the characterization of proteins to be used in cell therapeutics as well as protein tools required for therapeutic discovery and development programs and a robust protein QC process • The role will work with external partners for access to expertise, technology and capacity, help to build internal expertise and will interact extensive with all of the functions within the internal team. • Additional responsibilities will include participation on portfolio project teams as project lead and/or functional area expert
Qualifications: • PhD in Biochemistry or related life sciences field • +10 years in a biologics discovery organization, with a thorough knowledge of the biologics discovery process • Expertise in therapeutic protein purification methods development and implementation • Experience interacting with a protein therapeutic manufacturing team • Best-in-class expertise in the production of difficult-to-express proteins, including cell surface proteins and proteins exhibiting complex refolding requirements
Requirements: • Strong expertise in protein purification methods development • Robust working knowledge of antibodies, bispecific antibody proteins, antibody fragments (e.g., Fab and scFv), single-domain antibodies and non-antibody scaffold proteins • Expertise in therapeutic protein quality control methods development and evaluation • Experience guiding external partners for therapeutic protein production and large molecule discovery • Demonstrated success in leading therapeutic discovery programs • Demonstrated ability to positively influence corporate culture, team dynamics, and influence scientific rigor and productivity
About Century Therapeutics, LLC:
Century Therapeutics is developing novel allogeneic living cell products for oncology that overcome the limitations of first-generation cell therapies. Our genetically-engineered, universal iPSCs-derived immune effector cell products (NK, T, Dendritic cells, and macrophages) are designed to specifically target hematologic and solid tumor cancers. Our commitment to developing off-the-shelf cell therapies will expand patient access and provides an unparalleled opportunity to advance the course of cancer care. https://www.centurytx.com/