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Scientist, Antibody Development

Tonix Pharmaceuticals Inc
Frederick, MD
  • Posted: over a month ago
  • Full-Time
Job Description

Tonix is a global biopharmaceutical company, publicly traded on NASDAQ (ticker: TNXP). The Company is focused on discovering, licensing, acquiring, and developing small molecules and biologics to treat and prevent human disease and alleviate suffering. Tonix’s portfolio is primarily composed of central nervous system (CNS) and immunology product candidates. The immunology portfolio includes vaccines to prevent infectious diseases and biologics to address immunosuppression, cancer, and autoimmune diseases. The CNS portfolio includes both small molecules and biologics to treat pain, neurologic, psychiatric and addiction conditions. Please visit www.Tonixpharma.com for specifics on the pipeline.

Position Overview

Tonix is looking for Scientists and Senior Scientists with extensive experience in antibody discovery and development responsible for developing therapeutics in oncology, infectious diseases, and other antibody or protein reachable targets. The positions are at Tonix’s Research and Development Center (RDC) which is the innovation and development arm of the Tonix pharmaceuticals. RDC is responsible for providing efficient and cutting-edge treatment methods for various diseases including infectious diseases, oncology, and other indications. These positions will involve working as part of the research team to deliver and optimize biological pipelines for clinical investigation. The individuals in this position will participate in many aspects of antibody design, engineering, production, optimization, and development.

We are searching for self-motivated, resourceful, and adaptive scientists with industry mindset to join the antibody discovery and development team. The individuals in this position will have access to the state-of-the art technologies such as latest high-content imaging and Cytof. The individual will coordinate activities with other senior scientists and run an independent research program which may include development of novel informatic or computational program development.

These are fast-paced challenging positions offering a competitive compensation and benefits package. This position will report directly to the EVP of Strategic Development and will be based at the Tonix Research and Development Center in Frederick, Maryland.

Essential Duties
  • Use robotic, and automation to support novel engineered proteins and antibody design, production, purification, and screening
  • Conceive and design novel scaffolds molecules, including immune modulator and protein complexes, single- and multi-domain antibodies, various antibody fragments and fusion proteins to achieve or improve on target specificity, activity, and desired biological outcomes
  • Manage and participate in hypothesis generation, production, and identifying of unique biologics with high specificity and affinity to allow Tonix Pharmaceuticals competitively advance biologics pipeline in immunology, oncology, infectious diseases, and related fields
  • Biophysically and biologically assess binding properties of the novel proteins and antibodies by using various technologies such as SPR, flow cytometry, epitope screening, Octet, novel reporter-based assays, and high content plate-based imaging
  • Perform antibody engineering to improve potency and use of affinity maturation
  • Participate or initiate clonal selection, process optimization, process characterization, and expansion of the protein or antibodies using systems such as Ambr ® 250
  • Lead specific project teams or participate in related project teams
  • Propose new discovery and optimization path with industry mindset
  • Use strong interpersonal skills to elicit, synthesize, and manage the cross-functional inputs required for a robust development plan.
  • Generate hypothesis to test ideas, use the data set to evaluate hypothesis and design new studies
  • Apply multiple cutting-edge selection techniques to synthetic and immune antibody libraries, such as application of novel display systems, flow cytometric sorting, plate-based screening
  • Supervise and mentor members of the team and communicate well with peers
  • Uphold company mission and values through accountability, innovation, integrity, quality, and teamwork
  • Perform ad-hoc work/special projects as necessary to support Tonix on various business initiatives
Minimum Qualifications
  • Ph.D., or equivalent doctoral degree preferred
  • Documented relevant research experience in antibody discovery, design, development with two years of post-graduation experience
  • Knowledge and use of AI to enhance design and target engagement preferred
  • Strong accomplishment record demonstrating the ability to perform independent, high-quality, creative, and impactful research in the field of antibody or protein design and discovery
  • Deep knowledge of B cell biology including B cell memory generation and responses, humoral immunity, immunoglobulin genetics, isolation of antigen specific B cells required
  • Experience in various expression systems to perform high-throughput analysis of sub-clones
  • Sound working experience in industry or biological context, and the ability to interrogate data set such as high throughput data, preferred
  • Domain knowledge in some major area within life science for Pharma (e.g. infectious diseases, oncology, biomarkers, or in connection with high throughput technologies and their applications and pitfalls) preferred
  • Working knowledge of systems such as multi-parameter flow cytometry, including acquisition and analysis, required
  • Dedicated team player who is able to withstand the high demands of a fast-paced environment
  • Excellent written, organizational, and verbal communication skills are essential
  • Strong planning and organizational skills
  • Comfortable working independently with minimal supervision
  • Highly organized, results driven, problem solver, collaborator
  • Demonstrated ability to perform the essential duties of the position with or without accommodation

Tonix offers salary commensurate with experience and an excellent benefits package.

Tonix Pharmaceuticals Inc

Address

Frederick, MD
21701 USA

Industry

Science

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