Department: Cardiovascular Biology - Dr. Penchun Yu
The laboratory of Dr. Pengchun Yu in the Cardiovascular Biology Research Program at the Oklahoma Medical Research Foundation (OMRF) is seeking postdoctoral scientists to investigate the metabolic regulation of vascular formation and its implications in vascular diseases.
The laboratory focuses on the interface between cellular metabolism and vascular biology. Dr. Yu has recently demonstrated that MYC/hexokinase 2 pathway-driven glucose metabolism in endothelial cells controls blood and lymphatic vessel formation dependent on fibroblast growth factor receptor (FGFR) signaling (Yu et al., Nature, 2017). Research projects of the laboratory are built upon this important finding to further study the crosstalk between metabolic programs and angiogenic signaling events and to understand the involvement of cellular metabolism in the pathogenesis of vascular diseases. Multidisciplinary strategies will be employed, ranging from novel genetically-modified mouse models to cutting-edge systems biology tools including metabolomics and single-cell transcriptome analysis.
OMRF is an independent, nonprofit biomedical research institute. The innovative basic and translational research at OMRF covers several critical areas such as cardiovascular disease, autoimmune disease, and cancer. The institute offers postdoctoral fellows an exceptional research and training environment with state-of-the-art facilities and outstanding core technology laboratories. Moreover, postdoctoral scientists are encouraged to apply for OMRF Postdoc Travel Awards to support their attendance at meetings or workshops.
In addition to competitive salaries and comprehensive benefits, the successful candidates will be provided with strong support for developing an independent research career after postdoctoral training.
Ph.D. in a biological science, chemistry, physics or other relevant area, M.D., or equivalent (or expect to receive a doctoral degree soon).
Applicants must possess excellent experimental and communication skills.
Demonstrate solid training in cell biology, biochemistry, developmental biology, or mouse genetics with scientific publications. Previous research experience in metabolism is not required.
Regularly required to stand, use manual dexterity, talk or hear; Frequently required to walk and reach with hands and arms; occasionally sit; frequently lift and/or move up to 50 pounds; vision abilities include close vision, color vision, depth perception and ability to adjust focus. Potential exposure to fumes, airborne particles, or rodent dander. May work with toxic, caustic chemicals, radioactive materials, liquid nitrogen, human tissue or blood. Potential risk of electrical shock. Occasional exposure to cold 4C, and/or extreme cold -80C from freezers. Noise level is usually moderate.
Apply online at http://omrf.peopleadmin.com/postings/2874