Associate Director- Antibody Engineering

Your Opportunity:

We are a privately held, venture capital backed company with a mission to transform the treatment of kidney disease by reversing its progression and enabling and inspiring patients to resume their normal lives. We are developing first-in-class, highly targeted therapies for individuals living with both acute and chronic renal diseases. Our objective is to transform the treatment of renal diseases, providing patients with treatment options where currently few exist. You will have a great opportunity to help us bring this important mission to life

As a key member of our Molecular Sciences team, the Sr. Scientist / Associate Director, Protein / Antibody Engineering is responsible for discovering and developing novel therapeutic antibodies and proteins. The position reports into Head of Molecular Sciences and Information.

Responsibilities:

         Experience with protein engineering to facilitate small molecule chemistry-based drug screening

         Conduct cutting-edge research to develop novel antibody-based candidate therapeutics including developing novel scaffolds and antibody libraries

         Working knowledge of different antibody engineering approaches, understand different capabilities of these technologies and be able to execute or contract them appropriate to project needs

         Measure aggregation, solubility, stability and other parameters related to the manufacturability of candidate antibody therapeutics

         Produce purified candidate antibody therapeutics in quantities sufficient for animal studies

         Perform flow cytometry and sorting or other screening platforms

         Align and inspire more junior staff including technicians

Qualifications:  

         Ph.D. in Molecular Biology, Immunology, Biochemistry, Cell Biology, or related field with a minimum of 5 years of antibody / protein engineering experience in a biotech/pharmaceutical environment

         A track record of driving therapeutic antibody / protein programs from early discovery into development stage

         Extensive experience with phage or yeast display, flow cytometry and sorting, SPR, epitope binning and protein biochemistry

         Strong knowledge in antibody structural modeling, sequence prediction, and strong understanding of protein structure-function relationships

         High throughput screening, registering sequences and data management

         Experience building a positive, team-oriented culture with strong leadership and communications skills

         Strong passion for innovating and forward-thinking based on competent experimentation and reliable data

         Demonstration of leadership, problem solving, decision-making, and project management skills

         Open, highly collaborative and scientifically curious