Century Therapeutics is developing novel allogeneic living cell products for oncology that overcome the limitations of current cell therapies. Century’s genetically-engineered, universal iPSC-derived immune effector cell products are designed to specifically target hematologic and solid tumor cancers. Our commitment to developing off-the-shelf cell therapies will expand patient access and provide an unparalleled opportunity to advance the course of cancer care.
Century’s foundational technology is built on induced pluripotent stem cells (iPSCs) that have unlimited self-renewing capacity. This enables complex cellular engineering to produce controlled cell banks of modified cells that can be expanded and differentiated into desired immune effector cells, which can supply vast amounts of allogeneic, homogeneous therapeutic products. This platform differentiates Century from other approaches that utilize non-renewable donor-derived cells.
Century is looking for motivated scientists to advance the growing and promising field of cell therapy to treat cancer. The Scientist/Senior Scientist, Analytical Development will collaborate with Century’s Research and Manufacturing teams in order to harness the power of genetically engineered, adult stem cells to develop curative therapies for cancer. As a scientist experienced in developing and executing molecular biology assays, the successful candidate will guide assay development in order to advance our universal iPSC-derived allogeneic immune cell products for targeting hematological and solid tumors. He/she will be responsible for the selection, development, and validation of molecular biology assays to be used in the characterization and release of engineered immune cells in clinical development. The ideal candidate will work closely with scientists within the group and collaborate with members of various functional groups to achieve company-aligned goals. This position is based in our Philadelphia (University City) laboratory.
- Design and develop molecular biology assays
- Optimize and validate methods for cell line genetic characterization
- Partner with research teams to support program-specific activities
- Interface with manufacturing teams to transfer robust and GMP compliant methods for cell line release
- Foster a collaborative and scientifically rigorous team culture
- Periodic travel up to 25%
- Ph.D. in biotechnology, molecular biology, genetics or related life-sciences field with at least 3-6 years or MS with +8 years of experience in the biotech/pharmaceutical industry leading projects and performing molecular biology methods
- Robust hands-on experience developing assays for quantitative PCR (qPCR), digital droplet PCR (ddPCR), RNA-seq, whole genome / exome sequencing for genetic engineering and gene expression applications.
- Highly motivated, independent researcher with a desire to work in a laboratory-focused role
- Proven track record in cell line genetic characterization
- Demonstrated knowledge of process development, analytical method development, technology transfer, method qualification/validation, and manufacturing of biotechnology products.
- Experience with molecular biology assay (including qPCR, ddPCR, NGS, and other gene expression methods) development, optimization, and/or validation
- Applied knowledge of immune cell biology is preferred
- Familiarity with generation and interpretation of large datasets and visualization tools such as Spotfire is preferred