The Scientific Expert will utilize their experience and knowledge to design, execute research and development activities focused on engineered cell therapy technologies, with a focus on engineered immune cells. Key responsibilities include, but are not limited to: serving as a subject matter expert and lab support for the growth, maintenance and optimization of iPSC (induced pluripotent stem cells) cultures and their differentiation into various immunological lineage cells (including T Cells and NK Cells) ; design and execution of strategies to optimize iPSC growth characteristics and their differentiation into various immunological cells with a focus toward manufacturing; and interacting with research and CMC teams focused on engineered cell therapy platform development.
Experience with maintenance and differentiation of iPSC cells (preferably to hematopoietic cells) is essential for this position
• Research and thought leadership on iPSC platform development and optimization, in particular, the differentiation of IPSC cells to immunological lineage cells.
• Support the development of therapies focused on engineered immune cells
• Identify original, nascent solutions to address key scientific challenges required for platform success
• Maintenance of laboratory notebooks for proper documentation of all research activities
• Deliver reports, summaries, and presentations supporting experimental results
• Extensive experience with mammalian cell culture at small and large scales
• Exposure to cutting-edge cell engineering techniques
• Ability to independently propose, design, execute and report research projects
• Outstanding collaborative and communication skills
• PhD degree in biology, chemistry or related field with 5+ years of experience iPSC biology and differentiation protocols (preferably to immune lineages)
• Functional experience in molecular and cellular biology and assay development
• Working knowledge of protein biochemistry and basic gene editing technologies
• Understanding of basic flow cytometry or cell imaging technologies