The Astellas Institute of Regenerative Medicine (AIRM) is a wholly-owned subsidiary of Astellas Pharma and focused on the development and commercialization of stem cell and regenerative medicine therapies. Astellas is an R&D-driven global pharmaceutical company whose philosophy is to contribute to the improvement of people's heath around the world through the provision of innovative and reliable pharmaceutical products.
Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture. There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.
AIRM has a world-class R&D team, and is pursuing a diverse range of disease indications, ranging from macular degeneration (currently in clinical trials) and other ocular indications to vascular and autoimmune disease. AIRM's intellectual property portfolio includes pluripotent stem cell platforms -- both embryonic and induced pluripotent stem cells as well as other cell based therapy research programs. AIRM is headquartered in Marlborough, Massachusetts.
The Research Associate will support assay development and qualification activities by performing cell culture and wet lab experiments, analyzing data, drafting protocols, SOPs and reports. The individual will be responsible for execution of protocols with some guidance from supervisor and have the ability to summarize results independently. This individual will collaborate closely within the team and across functional groups to advance pipeline programs.
Essential Job Responsibilities:
* Utilizes established techniques in cell culture, cell and molecular biology, biochemistry, and immunology to generate and analyze data in an accurate and reproducible manner.
* Conducts experiments after discussion of the design and strategy with the supervisor.
* Contributes to assay development, optimization and validation.
* Performs literature searches and analysis as needed for assay development.
* Subcultures, differentiates, freezes and characterizes multiple cell lines using SOPs.
* Writes technical reports detailing procedures, outcomes, and observations.
* Follows SOPs and batch records.
* Maintains accurate record keeping in laboratory notebooks and appropriate databases in a timely manner.
* Maintains inventory of reagents and disposables and orders supplies as needed.
* May perform assays under GDP to support process development.
* S./B.S. in cell or molecular biology or related discipline with 3-5 years of relevant academic or industry experience
* Ability to work independently, as well as part of a team
* Self-reliant, self-motivated, detail-oriented, highly organized
* Willingness and ability to learn new skills
* Two or more years' experience with aseptic tissue culture technique
* Hands-on knowledge of molecular and cell biology analytical methods
* Capable of meticulous GDP record keeping
* Excellent communication skills
* Ability to analyze own data and write concise reports
* Must be able to work flexible hours, including weekends
* Previous experience with pluripotent cells, working knowledge of flow cytometry, qPCR, ELISA and/or HPLC experience is preferred
* Previous GLP/GMP experience
* Knowledge of automated methods for cell analysis
* Experience with assay qualification/validation and/or cell therapy products
* Knowledge of GMP, ICH, USP, JP, EU and global compendial regulations and guidance.
Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled
Category Research and Development