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Sr. Research Associate (Gene Editing)

Ascent South San Francisco, CA
  • Posted: over a month ago
  • Other
Sr. Research Associate
South San Francisco, CA

Summary
The ideal candidate should be experienced in the latest molecular cloning and sequencing techniques for the generation and analysis of transgenic T cells. The candidate should enjoy operating in an exceptionally dynamic and cooperative environment and will communicate results to and coordinate efforts with a larger cross-disciplinary team of immunologists, biologists, engineers and bioinformaticians.

Responsibilities
  • The candidate will be performing experiments to validate and improve the technology for gene editing (knock-in and knock-out) of endogenous and neoE TCRs, and analyzing the resulting data
  • She/he must be able to communicate clearly and concisely, both verbally and in the form of written reports. The incumbent will aid in drafting protocols, and provide data for regulatory documentation to support clinical development
Qualifications
  • Ideal candidate will hold a BS degree with 4+ years of experience with a focus on cell or molecular biology, biochemistry or molecular genetics
  • Candidate must have hands on experience with nucleic acid purification and use, including primer design, PCR and standard cloning
Following skills are a plus:
  • Experience with liquid handlers/automation equipment
  • Experience with informatics, data management, or programming
  • Mammalian cell culture and transfection, ideally primary human T cells
  • High-throughput sequencing sample preparation and analysis
  • Site specific nucleases (CRISPR and TALENs) and associated cellular and molecular analysis
  • qPCR and/or ddPCR assay design and optimization
  • Flow cytometry or FACS

Ascent

Address

South San Francisco, CA
94080 USA

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