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Associate Director, Global Health Economics and Outcomes Research

Ascendis Pharma
Palo Alto, CA
  • Posted: over a month ago
  • Full-Time
Job Description

Under the direction of the Head, Global Health Economics and Outcomes Research, the Associate Director, Global Health Economics and Outcomes Research will be responsible for leading the planning and implementation of HEOR studies to demonstrate and differentiate the value proposition and corresponding scientific evidence of Ascendis products for payers, patients, health care practitioners and other key stakeholders. Through project leadership and partnership across cross-functional teams, the Associate Director ensures the global HEOR evidence generation strategy is in alignment with broader endocrine rare disease area development strategies and global market access plans. The Associate Director, Global HEOR partners with and provides thought leadership to Market Access, Commercial teams, Regulatory, Clinical Operations, Clinical Development and Medical Affairs.

Key Responsibilities

  • Design and execute prospective and retrospective studies including database analyses, comparative effectiveness, meta-analyses/systematic reviews, and economic modeling to support the value proposition of Ascendis development assets.
  • Support development of disease-specific clinical outcomes assessments (PRO, ObsRO)
  • Follow best practices for HEOR data collection, analysis, modeling, dissemination and publication
  • Internal and external stakeholder collaboration in the execution of health economic and outcome research studies, including but not limited to retrospective claims analysis, prospective observational studies, patient-reported outcomes, comparative effectiveness research, network meta-analysis, and economic modeling.
  • Support design and development of global economic models and local adaptation for EU, Asia and North American markets
  • Support the development and execution of the HTA component of the HEOR strategic evidence generation plan based upon global market access strategy
  • Work closely with cross-functional teams (e.g., Medical Affairs, HEOR, Market Access, Clinical Development) to develop global core-value, AMCP and reimbursement/HTA dossiers within global regions.
  • Lead vendor management for the timely execution of health economics and outcomes research (HEOR) projects including but not limited to contracting, project management, and invoice approval.
  • Participate in the development, review, and writing of abstracts, posters, slide presentations, and manuscripts in support of evidence dissemination strategies.
  • Ability to review and summarize published HEOR literature including but not limited to economic cost analysis, patient reported outcomes, primary and secondary data analysis. This includes ability to conduct focused literature reviews and systematic reviews.
  • Manage multiple projects and budgets to target as directed as well as interact with vendors in the execution of HEOR projects.
  • Contribute to the development of product value propositions through product lifecycle


Knowledge, Skills and Experience

  • 8+ years of HEOR experience in the pharmaceutical or a related industry
  • Ability to travel up to 20% of the time domestically and internationally
  • Minimum of Masters degree required, (Ph.D. preferred) in Health Economics, Outcomes Research, Health Services Research, Public Health or related discipline.
  • Excellent communication skills, problem solving abilities, interpersonal skills and writing skills required.
  • Highly motivated self-starter who can deal with complex issues and relate to multiple internal and external stakeholders
  • Experience in payer tool development and data dissemination strategy, including dossier development and reimbursement submission.
  • Experience in global HTA engagement and appraisal processes
  • Experience in the design and development of budget impact and cost effectiveness models.
  • Expertise in the design and methodological considerations of real-world evidence studies, including administrative claims analysis, patient reported outcome data, electronic medical records and registry databases.
  • Expertise and understanding of global healthcare systems and payers.
  • New hires based in the US will be required to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption or accommodation to this vaccination requirement, subject to applicable law

Role Criteria: US West Coast,Remote. Requires ability to work in the Palo Alto Office 2-3 days per month.


  • Medical insurance
  • Vision insurance
  • Dental insurance
  • 401(k)
  • Paid maternity leave
  • Paid paternity leave
  • Commuter benefits
  • Disability insurance

Ascendis Pharma


Palo Alto, CA



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